TOPIC:

Hey friends,
Very happy to join you all on this forum, best and most up to date forum ever on the internet, about HepC that is!! At least that's what I think from reading around here there and every where else. Just so you know where I'm coming from, I got my meds delivered last week from China, Mesochem. I didn't order from Rachel though, her email address was having issues that night and wouldn't work for me, my emails kept coming back as undeliverable. Anyways, I ordered from Daisy, anyone ever order from her?? Is she acceptable, or did I just end up buying expensive Chinese lactose. j/k of course! The prices I paid are listed below. Many people in the US are very leery about ordering online especially from China, but how else you gonna get it?? And who sells for cheaper than China? Oh, and I didn't have a problem with Customs either, an officer called me and asked a couple of questions, had me fill out a form, I left the pdf below, held my package up a couple of days and blamo, two days later FedEx guy at my door with my package. You can order from China, or you can order from this HepC buyers club, linked on the bottom of the page, that way you can have your API's tested and capped..

Incidentally, I was approved for Viekira Pak through my Gastro and Blue Shield, but I don't want it b/c of the Ribavirin. My Gastro Doctor was really pissed off but I don't care cause I've taken that drug before in 2008 and I hated it.. Besides, two drugs in generic Harvoni is way better than 5 drugs of Viekira Pak any day of the week. My guess is I'd likely have more side effects from 5 HepC drugs than 2, besides Riba alone will make me anemic. I already know b/c I was in a clinical trial for Boceprevir but I only lasted a week and I am so glad I didn't last any longer on that nasty interferon. I don't know how anyone could go through that old treatment but they did, I salute them all. All I know is I couldn't so I didn't. Anyways, that's enough about me, I gotta get to sleep. ~Cheers!!

Sofosbuvir 40g 520usd totally include shipping cost by express
Ledispavir 8g 400usd totally include shipping cost by express

gp2u.com.au/fixhepc#sthash.55x1ekfz.dpuf

images.fedex.com/gtm/pdf/USS002.pdf

Welcome Fretboard, there is a lot of expertise here so fire away with any questions about taking your powder, but you probably have already researched that part.
That's a keen price from Mesochem, it has come way down from last year. And great to hear it sailed through customs.
This forum is run by the GP2U people out of Tasmania, but thanks for posting the links.

Hi FB and welcome!

Nice to hear your meds got to you with no problems We have quite a flock from the USA on this forum which im sure they will swing by your thread and introduce themselves. All the best with slaying the dragon.

Hi FB and welcome!
I live in Arkansas and got my meds from Mesochem last October. The prices have come down from the $1860 I paid it seems. The price you paid is the "going rate" now for what you got. I don't know Daisy, but if you sent your money to the Mesochem bank and got it through FedEx, you're probably good. I might ask Rachel if Daisy is legit...
I have my 12 week EOT bloods pulled today. I am pretty certain the crap is gone, we will see. The Mesochem APIs are real.
Are you making your own doses? I have quite a few posts covering that over in the U.S. Importation topic. I didn't have anyone to ask advice from when I started this process but James and Greg. You could do a lot worse. Hell, I still visit with them on a regular basis. So, if you need any hints or questions answered ask away. My email is below. Remember, you need to weigh 96mg of ledipasvir API to get the proper dose. A capsule funnel made it easy for me,
Welcome again and good luck!
Mike

Sofosbuvir 40g 520usd totally include shipping cost by express
Ledispavir 8g 400usd totally include shipping cost by express

You have too much sofosbuvir and not enough ledipasvir for 12 weeks treatment,

You need 400 mg per day of sofosbuvir (that is 34 g for 12 weeks)
You need 96 mg per day of ledipasvir acetone to deliver 90 mg of free base (that is 8.1 g for 12 weeks)

You should take it at night, without food, particularly if you are going to under-dose the ledipasvir, which you are, given you don't have enough.

James-Freeman-facebook wrote:

You should take it at night, without food, particularly if you are going to under-dose the ledipasvir, which you are, given you don't have enough.

About when to take ledipasvir,

I take my sof-led at 4 pm which is around 2 hrs after lunch.

For the best absorbtion, i want to change when to take from 4 pm to 10pm.

is it okay to just take my next sof-led at 10 pm and keep taking it at 10 pm from now on??

Thanks Doc,
Don't fret Fret. Send me a PM after you weigh up all you doses. I have some extra I could send you. How much do you weigh?
I weighed my first 28 doses using the Torpac Profunnel 00 size. Made things easy. One cap for each API. The AWS scales are delicate. When I weighed mine, I wasn't aware of the 96 vs 90mg requirement for the led. Since the scales were so sensitive, I just always weighed out at .095 or .096, never less. So, I got the right dose. Then, the insurance approved me for 8 weeks of Harvoni. I switched after my 4 week labs. The Mesochem APIs knocked the crap on its ass.
Good luck,
Mike

Yes, stomach acid is highest 2200-0600 so this is the best time to take Ledipasvir to maximise absorption with APIs.

Most people are more than adequately dosed so the mild reductions with food make no difference. Our new member from California is 1.5% short of requirements - almost certainly irrelevant - but dose absorption can be optimised with night time dosing.

Welcome fretboard yes you are in the right place as you say. I just finished my 12 weeks of sof/led yesterday, so far all is clear, a miracle really.
Any queries along the way I just blogged here and got help fast, but truly, it was such an easy treatment,, hardly anything to complain about , at the start I rang FIxHepC at Hobart, just to ask some basic routine questions, as you have already done and got your answers...there are a few friends here like Mike who is experienced and can point you in the right direction, being in the US and all. Anyway. wishing you the very best for your treatment, hope you get the best result. From Ariel in Oz

Hi Fret. I'm in California, too. I also got Mesochem product through Australia. Good stuff. Can't wait to see your blood test results!!!

Welcome Fretboard! You made the right choice! Forget Viekira Pak....Mesochem has cured many! Sof/Led is the drug of choice for you! Good Luck!!

Wow! I really appreciate all the responses!! This forum is Super!! Do I have to worry about being on 40mg of Pantoprazole daily because of absorption issues? Do I need to stop taking it? Take it less? Its for GERD, generic Protonix? I did some testing on myself and Ive determined that I will be alright if I take it once every 3 days. Is it best to just stop taking it when I start tx?

Hey fretboard This whole absorption thing is quite in depth and I'm pretty interested as there is some question regarding me absorbing the meds well .... From what I am reading, adequate amino acids play a part in absorption, I guess you can help yourself with diet too. Found a great website regarding this. Beware of taking suppliments while on treatment though and always check first.

aminoacidstudies.org

Good luck with everything, wishing you all the best

Welcome fretboard,

You may find the following link to Liverpool Drug Interaction Checker useful during your treatment. Just tick Lepidasvir/Sofosbuvir in the hep drugs column and whatever else you need to check in the Co-medications column and it will show you any expected interaction such as the one you asked about.

In this case the Pantoprazole is similar to Omeprazole and other PPIs which have been discussed here a number of times. So use the Search tab at the middle top of this page to look for Omeprazole. It looks like the recommendation is to avoid it if you can (or consider changing the Ledipasvir for Daclatasvir if you can't) but I will leave you to read what others who know more on the subject have to say.

www.hep-druginteractions.org/checker

Gaj
Great! Much appreciated! I'll check this out right away. Any idea what alternate ideas I could use to deal with the GERD?