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Sofosbuvir Daclatasvir 7 years 2 weeks ago #152

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Dear Dr. Freeman,

How do you encapsulate these Dac-fillers? What are the ingredients?

What is needed for Sofosbuvir? How many grams? Ingredients? Is this also possible?

Thanks for answering!

Live life

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Sofosbuvir Daclatasvir 7 years 2 weeks ago #153

Hi Live life

I am glad you posted this because I also have questions about encapsulating the Mesochem APIs.

1.
What size capsules are needed for 400mg sofosbuvir / 60mg daclatasvir?
2.
I am doing it myself and I understand that fillers are not required. Is that correct?
3.
Once encapsulated, do the capsules need to be stored in the fridge? Once stored correctly, can they be expected to remain viable for 6 months from date of encapsulation, provided that the dry bag of powder as shipped had an expiry date of at least one year?

Thanks,
dointime

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Sofosbuvir Daclatasvir 7 years 2 weeks ago #154

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I'm happy your happy!

Does the powder has to stay in the fridge as well for now?????

Many Thanks!

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Sofosbuvir Daclatasvir 7 years 2 weeks ago #158

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Hi

I will wait for the good doctor to answer this however I've had the same conversation with him at my last skype visit. Apparently there are options here but best to use a vegetable extract filler and can be compounded using digital scales and filler kits. Really fiddly but can be done, for $70AU I'm having mine done by a compound chemist. Re the filler name eludes my brain atm and with these drugs there is no need to use with fats for better absorption like with ribavirin and other meds, that's assuming you're not using ribavirin.. Storage I believe is room temperature within reason but like I said, James will get back to you on this. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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Sofosbuvir Daclatasvir 6 years 11 months ago #905

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Hello! It's Life again!

So were you able to encapsulate?
Have everything since this week, just don't know where to start with ingredients (where to buy)

Could we get in contact, somehow....

Thanks for replying!!

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Sofosbuvir Daclatasvir 6 years 11 months ago #1135

I put daclatasvir and sofosbuvir together in the same capsule, whether it is a problem?????

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Sofosbuvir Daclatasvir 6 years 11 months ago #1136

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I don't think it would be an issue as long as you've got the measurement/mix right. I'm downing both at the same time so same same. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
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Sofosbuvir Daclatasvir 6 years 11 months ago #1139

I just thought I'd have to throw it and buy a new API

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Sofosbuvir Daclatasvir 6 years 11 months ago #1150

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was it mixed to a ratio of 400 sofo to 60mg dac before you capped them? Or are we talking 50/50? That wouldn't work but the previous would. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
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Sofosbuvir Daclatasvir 6 years 11 months ago #1229

We have been doing accelerated stability testing on this and it seems fine.

Do not worry, as soon as medications arrive in stomach they mix freely anyway.
YMMV
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Sofosbuvir Daclatasvir 6 years 11 months ago #1237

Tnx a lot Emilio and James Freeman

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Sofosbuvir Daclatasvir 6 years 11 months ago #1238

Emilo I mix 400 sof 60dac before capped.tnx

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Sofosbuvir Daclatasvir 6 years 11 months ago #1266

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all good mate, start eating and getting better ;)
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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Mesochem 6 years 11 months ago #1267

We have seen quite a lot of their product from at 6 different batches (when last I looked) and it has been consistently good in terms of closely matching our reference standards.
YMMV

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Sofosbuvir Daclatasvir 6 years 11 months ago #1284

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Hello Agivanos!
Life here! I'm capsulating seperate...I don't find sofos easy to do because it's another texture then Dac...You think so too?

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