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Looking for treatment advices 8 years 6 months ago #987
My mother in law is living in Beijing China, 78 years old. She was infected with HCV genotype 1b from blood transfusion due to a surgery at hospital in early 80s. Her situation is pretty bad right now, decompensated cirrhosis, CTP-C, also has oesophageal varices which causing internal bleeding in Feb 2015. Is it safe for her to take new DAAs to treat Hcv at this stage? Any successful cases like her? Which combo - SOF/DAC or SOF/LED is best in her situation? Thanks | |
Looking for treatment advices 8 years 6 months ago #996
24 weeks of Sof/Dac or Sof/Led would help. No Riba. My impression is that Sof/Led might have a slight side effect edge so may be more gentle. Both are gentle treatments. The typical treatment experience is feeling better than for years within a week of starting. It is hard to say how many years of life it might add, but those years may well be better. It would certainly be worth giving 12 weeks to start and then next 12 if that goes well. If you need help with sourcing Buyers Club can help and price is less for delivery in China because that is source country. You could probably have delivered on Monday. YMMV | |
Looking for treatment advices 8 years 6 months ago #998
Thank you Dr Freeman for the advice. Dr Freeman, do you happen in contact with any Chinese doctor in Beijing are familiar with those new treatments and willing to write prescription for generic and follow up monitoring? Apprantly, same as many other places, we have not found any doctor is willing to do so. One of the doctor she was seeing suggested Sof/Riba combination for 12 weeks which is not recommended to my understanding. I was think about API when I learned it here and Greg's blog, however, we could not find anyone in Beijing willing to compound. DIY is not possible considering their age and conditions, we are living in Canada and could not help much with that. For the moment, I am trying to source twinvir, if not successful, then we will fail back to APIs. Thanks again! | |
Looking for treatment advices 8 years 6 months ago #1000
| Hi Dr F and tweak max, Do you feel the Sofo/Led may be a little more gentle for most? I'm also GT1a and trying to decide. Does the How do DAC and LED differ ? Thanks GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
Looking for treatment advices 8 years 6 months ago #1002
Hi London girl, I will let u know the side effects once I start (hopefully soon) What did ur doc recommend u? After reading so many articles, I think if u can get your hands on either sof + dac or sof + led, just use either combination. | |
Looking for treatment advices 8 years 6 months ago #1005
| Hi TM, My Dr hasn't recommended me anything - I am in England I will ask at next appointment. GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
Looking for treatment advices 8 years 6 months ago #1006
| hi LG,have a read of EASL HCV TREATMENT GUIDELINES 2015 SUMMARY.its a very clear and consise bit of info.sorry dont know how to do a link. gt3 started sof dac jan 2016 now 48 wks svr. not the real wilko johnson just have the same real name. shropshire uk The following user(s) said Thank You: LondonGirl |
Looking for treatment advices 8 years 6 months ago #1007
Do you have any info about twinvir and its effectiviness? Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured | |
Looking for treatment advices 8 years 6 months ago #1014
| Thank-you Wilko, will revisit, have been waiting for Harvoni, but now there is the Sofo/DAC option. Engle, I do hope you can get sorted out to help your Mother, God bless her. GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
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