TOPIC:

My mother in law is living in Beijing China, 78 years old. She was infected with HCV genotype 1b from blood transfusion due to a surgery at hospital in early 80s. Her situation is pretty bad right now, decompensated cirrhosis, CTP-C, also has oesophageal varices which causing internal bleeding in Feb 2015. Is it safe for her to take new DAAs to treat Hcv at this stage? Any successful cases like her? Which combo - SOF/DAC or SOF/LED is best in her situation?
Thanks

24 weeks of Sof/Dac or Sof/Led would help. No Riba.

My impression is that Sof/Led might have a slight side effect edge so may be more gentle. Both are gentle treatments.

The typical treatment experience is feeling better than for years within a week of starting.

It is hard to say how many years of life it might add, but those years may well be better.

It would certainly be worth giving 12 weeks to start and then next 12 if that goes well.

If you need help with sourcing Buyers Club can help and price is less for delivery in China because that is source country. You could probably have delivered on Monday.

Thank you Dr Freeman for the advice.

Dr Freeman, do you happen in contact with any Chinese doctor in Beijing are familiar with those new treatments and willing to write prescription for generic and follow up monitoring? Apprantly, same as many other places, we have not found any doctor is willing to do so. One of the doctor she was seeing suggested Sof/Riba combination for 12 weeks which is not recommended to my understanding.

I was think about API when I learned it here and Greg's blog, however, we could not find anyone in Beijing willing to compound. DIY is not possible considering their age and conditions, we are living in Canada and could not help much with that. For the moment, I am trying to source twinvir, if not successful, then we will fail back to APIs.

Thanks again!

The doc is right.

You can use twinvir. It is for type 1.

I am type 1a and I am going to use that

Hi Dr F and tweak max, Do you feel the Sofo/Led may be a little more gentle for most? I'm also GT1a and trying to decide. Does the How do DAC and LED differ ? Thanks

Hi London girl,

I will let u know the side effects once I start (hopefully soon)

What did ur doc recommend u?

After reading so many articles, I think if u can get your hands on either sof + dac or sof + led, just use either combination.

Hi TM, My Dr hasn't recommended me anything - I am in England
I will ask at next appointment.

hi LG,have a read of EASL HCV TREATMENT GUIDELINES 2015 SUMMARY.its a very clear and consise bit of info.sorry dont know how to do a link.

Do you have any info about twinvir and its effectiviness?

Thank-you Wilko, will revisit, have been waiting for Harvoni, but now there is the Sofo/DAC option.

Engle, I do hope you can get sorted out to help your Mother, God bless her.