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James-Freeman-facebook wrote: Who says there is no such thing as fairytales.

And Tweakmax lived happily ever after sounds like one to me.

Thanks Doc!

Do you know what is the percentage of people who have svr12 and subsequently go on to svr24? very little percentage will fail svr24 right?

My doc didn't order SVR24 VL test for me, only fibroscan. She seemed confident about the "cure".

Should I be doing "POOR MAN's VL test" (ALT/AST) every month, just to be sure?

Data shows that a 12 week is just as accurate as a 24 week test.

But since you'll probably continue to wonder, you could save the money and have a Qualitative Viral Load test at 24 weeks instead of monthly liver enzymes. It gives you a negative or positive result but I believe it's cheaper than a Quantitative test. You can check with the lab in your country.

P.

I love this part of the story. Congratulations Tweakmax!!

I found this Tweakmax:

www.hepmag.com/blog/hepatitis-c-treatment-svr

More than 9 out of 10 people will be cured using the current treatments for chronic hepatitis C virus infection. It is thrilling to be told that hepatitis C is no longer detectable in your blood. However, as much as we yearn for those words, sometimes it takes a long time to believe that hepatitis C is gone forever.




The medical term for a successful hepatitis C treatment outcome is sustained viral response (SVR). Undetectable HCV for 24 or more weeks after the end of treatment is an SVR24. Recently, many studies use the term SVR12, meaning that hepatitis C is undetectable for twelve or more weeks after the end of treatment. For those of us had a hard time believing that being viral-free for 24 weeks meant we were cured, then 12 weeks felt unbelievable. Can we trust this?




For most of us, yes. In the January 2015 Hepatology, Eric Yoshida and colleagues reported that there wasn't much difference between an SVR12 and SVR24 among hepatitis C patients who were treated with regimens using sofosbuvir. It didn't matter if interferon was part of the regimen. Analyzing data from studies using sofosbuvir, researchers looked at response rates for genotypes 1 through 6. There were a total of 327 genotypes 1, 4, 5, 6 (mostly genotype 1); 294 genotype 2s; and 250 genotype 3s.




Results

Before presenting the results, there are a couple more terms that are important to understand:

•Relapse was defined as having a negative hepatitis C viral load (HCV RNA) at the end of treatment and subsequently having detectable HCV RNA above the LLOQ.
•In this case, LLOQ is lower limit of quantification, which is the lowest amount of virus that can be precisely counted.

SVR24 was achieved in 777 of 779 patients (99.7%) with SVR12. This means that everyone but two people who achieved an SVR12 had an SVR24. Here's the kicker: the two patients who didn't achieve an SVR 24 both had genotype 3 (both non-cirrhotic, treatment-experienced). Therefore, if you discarded the data for genotype 3 patients and counted everyone else, 100% of those who had an SVR12 had an SVR24. Using viral sequencing, these cases were relapses and not reinfection.

tweakmax wrote: My doc didn't order SVR24 VL test for me, only fibroscan. She seemed confident about the "cure".

Hi tweakmax,

You already had a happy SVR12 so I wish you a happy SVR24 and only UND!

We are waiting for you in the SV24 club!

2 more weeks to svr24!

As W said: "Mission Accomplished".
Well done!
Happy for you.
m

Picked up my path request too Tweakmax so hope to shake hands at the SVR24 finish line with you
Happies and bring it on !
Ariel

thank u one more week to go!

very encouraged to hear the Romanians on fb, 200 of them cleared their G1b with twinvir!

Hi Tweakmax,

Very interesting and pleasant news, thank you for sharing it.
Would you perhaps have a link to fb to post here or to send it to me via PM?

I believe it would be a nice information to put also on Twitter , especially that I've noticed there are not so many articles / information available in Romania about the HCV generic drugs.

Cheers,
RHF

A Romanian guy named Vlad rusu told me. Are u on the hep c without borders fb group? There are quite a number of Romanian friends there.

He told me a lot of Romanians are type 1b hence using twinvir