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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6695

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39 years I've had this bug - I'm certainly ready to be rid of it!

Took my first Sof/Dac pills last night. Had some insomnia - woke up at around 3.30am and couldn't get back to sleep - could be emotional, I'm not sure. Sleepy tired today, could just be the lack of sleep.

Took the pills at 9pm. Planning to hit the bug just that little bit harder at first by taking each dose an hour or two earlier each day till I get to early morning. Tonight - 7-8pm. Has anyone else done this?

Being very careful with Dac interactions. Avoiding all vitamins, herbs, citrus fruits.

Luckily for me I'm not working for the next few months, so I can take it easy.

Here we go - Phoenix is rising from the ashes! :cheer:
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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6697



Rise Phoenix! Brush off those ashes and burn away those little buggers!!

Backing up the dose a bit each day is the way to go. I am on sof & led, but sleep makes all the difference in the world for me, so I have always taken it first thing in the morning. A dull headache the first three days. That was it...

Good Luck!
Mike
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6698

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Thanks Mike. Love the pic and the avatar! :lol:
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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6699

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Phoenix wrote: Being very careful with Dac interactions. Avoiding all vitamins, herbs, citrus fruits.


You may be being overly cautious here. Most vitamins and herbs can be helpful and I'm certainly not stopping my daily ones. I just checked the drug interactions site and the only one contraindicated (of the ones I checked) is St John's Wort, with antacids and grapefruit as "potential". Even cannabis is not contraindicated and I can vouch it helps with the common sleep deprivation many people here have reported, although I wouldn't do it every day. ;)
There is also a thread on this forum about B12 and it's probability to increase the efficacy of DAAs.
Check here - www.hep-druginteractions.org/checker

Lotsa luck with your Tx!


M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia
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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6701

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Thanks for the thoughts, Sonix. For me though your post is an example of not being cautious enough. The Wikipedia page on CYP3A4 lists Valerian, Gingko Biloba, Milk Thistle (how many of us take that!) and Piperine (= black pepper) as "inhibitors" of CYP3A4. I'm sure these lists are not exhaustive either. Have a look at this site, for example:

www.ganfyd.org/index.php?title=Inhibitors_of_CYP3A4

I think I'll cut and paste this into the other thread I've started on Dac interactions.

Food for thought?

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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6704

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Food for thought indeed. I love pawpaws and it's a good season for them now, but they are mentioned on that page you linked.
I'd like to hear Dr James comment on this.
M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia

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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6705

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Definitely something to consider...would it be better to be overly cautious? Hmmm I did eat a whole lot of tropical fruit last night *ahem*

Great to hear you've started treatment Phoenix! I'm only just in front of you by one day. Interesting idea about staggering doses back - I started at 6am so is a bit more awkward to give that a go...finish up with an afternoon dosage cycle? :unsure:
GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26

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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6712

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sonix wrote: Even cannabis is not contraindicated and I can vouch it helps with the common sleep deprivation many people here have reported,


Hi Sonix,

SSshhh! You'll get some of the others grumpy with me for recommending against it in another post somewhere around here. ;)

Actually my reasoning for doing so is that it is an inhibitor although relatively mild. The problems are that you never know what the size of your dose will be (not just talking stoned vs wiped but also the various levels of different forms of cannabinoids in each dose) and also being absorbed by fats it hangs around in your body for several days to weeks afterwards. Plus the other chemicals from smoking it that your liver must process. So I figure that for 6 months I can add that to things like alchohol that my body will survive without. And probably thank me for not adding to its workload while healing my liver. And you specialist/GP can prescribe what are probably more benign sleeping aids if necessary. Of course YMMV.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6715

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@GAJ Yeah I would definitely not recommend regular use. My experience is a couple of puffs at a mate's place and having a good night's sleep for a change.

Sorry if we're hijacking your thread, Phoenix, but need to make it clear.
M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia

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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6716

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No problems at all sonix. The thread goes where it goes... B)
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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6718

Good luck Phoenix - wishing you the best possible outcome.
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6719

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Thanks LondonGirl! Day 2's dose is an hour away - feel like I'm in the swing of it now. I've had a real sloth cave of a day. I think it's an emotional hump - memories of interferon horror. This is going to be different! :)

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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6727

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Hi Phoenix,
Good luck and UNDETECTED soon!
And let us know your journey toward being healthy again! :lol:
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6729

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Hi Phoenix,

Just realised I haven't even said hello. :blush:

Congratulations on starting treatment!!!
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:

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Phoenix rises with help of Sof/Dac 6 years 8 months ago #6731

Phoenix wrote: Thanks LondonGirl! Day 2's dose is an hour away - feel like I'm in the swing of it now. I've had a real sloth cave of a day. I think it's an emotional hump - memories of interferon horror. This is going to be different! :)


This isn't like that fucking Rat Poison, hopefully you will have a much better experience on your new meds :)

Enjoy the ride.
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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