TOPIC:

Hi AA, Congrats on starting Tx! I started Spf/Dac too, on Wednesday. I've been having a 'speedy' sensation and then 'crashing', intense sweating, very emotional moodswings - feel happy and joyful/crying and 'grieving'; had 2 great nights of sleep but the snapping awake suddenly is there, I'm doing so much more during the day that i've been utterly trashed at night and feel asleep easily and slept solid for past 2 nights.

Good Luck and look forward to hearing about how your experiencing your Tx.

Thanks Folks appreciate the support and kind words ,so far day 3 just a little tired feeling and a slight dull head ache,only 81 to go and if it stays like this and it's gone it will be worth every day

Hey there AA Day 5 here and yep a relapser peg/inf too woah two attempts that's major
Well I am similar to Chejai re sweats and my hearts pounding today so taking it easy but that's kinda it as far as sx
Bit of a headache drinking heaps of water
This is very manageable compared to that ol devil Peg/Inf I just gotta get used to this pounding heart it is worst today may well be normal by tomorrow seems to come and go
Good wishes to you and happy travels we can only go forward from here

Hi AA and welcome!
You are very courageous. Two times on IFN means something.
I was so frightened of IFN, so I refused it in 2012.
But the new medicines DAA are amaizing. They are efficient with almost no sides.
Good luck and let us know of your journey!

Hi Ariel yeh 2 cracks on the bad stuff tested me but I got through it :0 it was very unpleasant but I had to try ,ya never knowif ya don't give it a go
All I have is a slight consistent head ache and tiredness ,sleeping well but still feeling tired,but I'll get through it and good luck to you and the journey

Hi isaing4 not courageous :0 some say stubborn I just wanted this thing gone and will try all most anything to rid my body of it and I was frightened of the peg too but had to try and it was hell on my mind and body ,not sure how the mind will cope if this fails me this time ,am feeling ok so all good so far

1 round of DAAs is going to feel like 1 round with a powder puff rather than 2 rounds with Mike Tyson.

For GT3 it looks like this:

Sofosbuvir Daclatasvir

NAIVE
default: svr: 97%, trials: UN-NAMED IIb (24wk) 89% (16/18) ALLY-3 97% (73/75) AASLD-2015 96% (24/25) Aggregate 97% (97/100)
w24: svr: 100%, trials: AASLD-2015 100% (29/29)
F4
default: svr: 65%, trials: ALLY-3 58% (11/19) AASLD-2015 70% (23/33) Aggregate 65.4% (34/52)
w24: svr: 90%, trials: AASLD-2015 86% (116/135) overall but Child-Pugh A 90% (90/100)
riba24: svr: 81%, trials: AASL-2015 81% (39/48)
FAIL
default: svr: 86%, trials: ALLY-3 94% (32/34) AASLD-2015 86% (89/103) (bias by F3/F4)
FAIL+F4
svr: 64%, trials: ALLY-3 69% (9/13)
w24: svr: 86%, trials: AASLD-2015 86% (89/103)
riba24: svr: 80%, trials: AASLD-2015 80% (28/35)

Now that's the good oil James these bangin headaches can be rather mood making, yes too true this is nothing like that vile black hole some of us were plunged into and to do it twice AA or like Em to go through 60+ weeks woah
I made a little movie of my peg/inf trip and I watched it yesterday to remind me of just how much easier this is
Not Gen3 here but Gen1a
However that said, the point is only a few watchable, personal manageable sx compared to being in hospital on tube feed etc well you just can't complain about this magic
Thanks James and team

Just past the 2 week mark only 22 to go and all going well a bit tired sometimes and a bit of a head ache now and then but other than that all good,I just hope this stuff is working and doing it's job,blood test in another few weeks so time will tell suppose.

Hey AA I know that feeling
I'm hanging out to get my bloods done too
Relapsers we have this little in one ear I think
But I have faith in this stuff
Migraine would describe my head but the initial night sweats have gone
Day 18 here and I noticed that this week my moods are not as stable as they were at the start
I'm sure when we get our bloods done that a massive relief will come
Wishing you a restful weekend
Ariel

Yeh thanks Ariel,I have faith init as well it's just some of the demons of treatment past that keeps coming into my thoughts ,I'm on day 16 and look forward to the last day and hopefully a clean bill of health ,Ya never know if ya don't give it a go
All the best to you as well,

Hi AA,

Once you see your 4 week results many of the demons will lose their powers, and then things just improve week to week. While I still have very occasional moments of doubt, at 10 weeks there is more confidence than ever felt during prior Tx. I can just sense my body winning the fight and regaining health, as you will!

Hi Gaj,

Thanks for the encouraging words,I'm more interested in the 24 week results rather than the 4 week but if the 4 week are good that's great and a positive step in the right direction,not getting hopes up too much but staying positive that this 3 rd attempt will work ,I was very disappointed shattered actually when the last 2 attempts didn't work so just not building hopes too high this time so I'm not mentally shattered if it doesn't.
I will win this fight eventually,I'm very stubborn and don't like to be beaten and I WILL NOT let this virus beat me If You Don't Fight You Lose

Yes AA,
The third time will be the charm!
The dac will seal the deal.
Good Luck!
M

Thanks M I hope your right