Hi Keith, This is a dilemma for you, to have a sufficiently high fat meal to maximise the bioavailability of your ribavirin dose yet simultaneously maintain a weight reduction diet. And that suggested 50g fat dose would be a crazy amount for just one meal with all you have going on.
This research paper mentions ribavirin bioavailability increasing by up to 46% if consumed with a high fat meal [ref: Wade JR, Snoeck E, Duff F, Lamb M, Jorga K. Pharmacokinetics of ribavirin in patients with hepatitis C virus. Br. J. Clin. Pharmacol.62, 710–714 (2006)]. Annoyingly I could not find its definition of high fat.
Back in 2006 it was pre-DAA days, so the need to get every ounce of benefit out of the ribavirin would have been pre-eminent. I wonder if it is not such a priority now we have our DAAs?
A moderate fat breakfast like those mentioned further back in this conversation may be the best thing for now. That way, you get sufficient fat to assist ribavirin absorption, without giving yourself a heart attack. With any luck someone else here knows more about this topic. Cheers
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!