Does Twinvir uses solid dispersion?
Ledipasvir exhibits low, but pH-dependent, solubility and high apparent permeability (BCS class II). It is
susceptible to the influence of gastrointestinal pH and fed state and so an amorphous spray-dried
dispersion of LDV (LDV-SDD) was developed in order to mitigate these food effects. LDV-SDD is an
amorphous solid powder. It is hygroscopic and photosensitive, but physically and chemically stable for up
to 6 months if protected from light and moisture in a sealed container. The physicochemical properties of
LDV-SDD are amenable to formulation in a solid oral tablet.
www.ema.europa.eu/docs/en_GB/document_li...3850/WC500177996.pdf
Edit: this technology used in Harvoni or maybe in Lesovir-C does not change a thing. it is just a marketing.
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured