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Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1435

  • Enkel
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I see that people prefer Indian generics that are licensed by Gilead. I think that Gilead gives them only permission to produce. Gilead does not invest a bit for the quality of Indian generics. Where Indian Pharma takes the APIs?
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
The following user(s) said Thank You: LondonGirl

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Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1443

Bangladesh will be the first country to be able to prove the clinical quality of their generics in the only way possible, via a 3000 person clinical trial the tracks the outcome for taking that specific formulation.
YMMV

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Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1446

  • Sirchinenge
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There is no Bangladesh V India.

When Greg started he had contacts in China and India hence you bought
from either one depending on Geno Type.

Early on, Greg had no contacts in Bangladesh he had no safe way to offer Twinvir.

The Buyers club came along and offered to buy direct from China they now have the
trials offering other products.

Honestly, I see no reason to get bogged down in Gilead's agreement with any
Generic maker in India.
Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.

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Last edit: by Sirchinenge.

Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1449

  • Enkel
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The idea is that some people wait for Hepcinat LP while they have at the moment Twinvir. Is the product of Natco better than the one of Incepta?
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured

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Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1451

This is a fair question - Is there a difference in medicines or is it just patients feeling more 'secure' with the official generic?
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
The following user(s) said Thank You: Enkel

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Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1452

  • Enkel
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Does Twinvir uses solid dispersion?

Ledipasvir exhibits low, but pH-dependent, solubility and high apparent permeability (BCS class II). It is
susceptible to the influence of gastrointestinal pH and fed state and so an amorphous spray-dried
dispersion of LDV (LDV-SDD) was developed in order to mitigate these food effects. LDV-SDD is an
amorphous solid powder. It is hygroscopic and photosensitive, but physically and chemically stable for up
to 6 months if protected from light and moisture in a sealed container. The physicochemical properties of
LDV-SDD are amenable to formulation in a solid oral tablet.
www.ema.europa.eu/docs/en_GB/document_li...3850/WC500177996.pdf

Edit: this technology used in Harvoni or maybe in Lesovir-C does not change a thing. it is just a marketing.
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured

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Last edit: by Enkel.

Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1453

I don't really understand what you are saying Enkel.
Sorry - can you simplify?
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1454

  • Enkel
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Solid dispersion used for ledipasvir does not increase the effectiviness of medication being it harvoni or any drug claiming the solid dispersion.
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
The following user(s) said Thank You: LondonGirl

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Indian Hep c Generics versus Bangladeshi Ones 6 years 11 months ago #1456

Ah , so someone was saying that was a problem but it's not?
I see.

It's good to have some clever people on here :)
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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Last edit: by LondonGirl. Reason: adding something
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