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cheat sheet 6 years 11 months ago #6305

Hi there,
I managed to get myself Lesovir-C brought back to me from Bangladesh almost 2 weeks ago and as I am in the middle of Mexico and basically self treating I was hoping somebody could answer me a couple of questions that are on the cheat sheet. Out of the following sentence...

4/52 into treatment FBC, Cr&E, LFTs, Hep C Viral Load

...I am not clear on 4/52, Cr&E and LFTs. I assume FBC is Full Blood Count and viral load i get.
Thanks in advance to anyone who can clear this up for me,
Ken
HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL
8 weeks tx ALT 29/ AST 34. VL UND
4 weeks after tx UND. SVR4. ALT 24/AST 18

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cheat sheet 6 years 10 months ago #6311

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Hi Ken

I copied this info from previous threads by using the search function. I hope this helps and all the best with tx in Mexico.

FBC Full Blood Count and LFT Liver Function Test

CR&E Urea, Electrolytes, Creatine

4/52 is doctor code for 4 weeks

8/52 would be 8 weeks

Lin
gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc

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cheat sheet 6 years 10 months ago #6313

.Thanks Lin,
I will start posting my results from the Lesovir-C as soon as I have some new info. It doesn't get as much "airtime" here as the twinvir. All iI know is that so far, after 13 days of tx, i hav had no side effects and for the last 4 days I have flelt better than I have in years. I am genotype 1a. F3 on my last fiboscan. Viral load around 5,500,000. Enzymes about 10x what they should be.
See what the test results come back as this week,
Ken
HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL
8 weeks tx ALT 29/ AST 34. VL UND
4 weeks after tx UND. SVR4. ALT 24/AST 18

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cheat sheet 6 years 10 months ago #6323

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Hi I have similar status as you , but using mesochem .Will you be doing 12 or 24 weeks. Good luck. Jill
Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
24weeks mesochem sof/led as unsure of fibrosis status.
currently UND. No bad side effects
Have svr12 ... waiting for svr 24
I now have SVR 36 weeks.

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cheat sheet 6 years 10 months ago #6324

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Hello kenbasman,

Essentially you don't strictly require any monitoring unless you get unwell but:

4/54 == 4 weeks post starting treatment

FBC = Full Blood Count = CBC = Complete Blood Count
Cr&E = Creatinine & Electrolytes = UEC = Urea Electrolytes Creatinine
LFTs = Liver Function Tests like Bilirubin, ALP, AST, GGT, Albumin
Hep C Viral Load = Quantitative HCV RNA

The 4 week test typically shows (80%) viral load zero and proves the meds are valid and working.

If you want an early proof your AST will fall rapidly back to normal

Once viral load is zero there is really not a lot of need for further monitoring (unless on Ribavirin)

The 12 weeks versus 24 weeks length decision is based on Fibrosis. If you have cirrhosis (F4, > 14 kPa, Hepascore > 0.5) then you need 24 weeks.

Next test after viral load zero can be SVR4 or SVR12 - Viral load 4 or 12 weeks post finishing treatment, and a VL=0 at 4 weeks = 96% chance of cure, and at 12 weeks 99% chance.
YMMV
The following user(s) said Thank You: Tommy

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cheat sheet 6 years 10 months ago #6325

Thanks Doc!
HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL
8 weeks tx ALT 29/ AST 34. VL UND
4 weeks after tx UND. SVR4. ALT 24/AST 18

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cheat sheet 6 years 10 months ago #6341

I told my GP about the cheat sheet, he looked extremely interested and jotted down the url. :)
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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cheat sheet 6 years 10 months ago #6343

Jill,
I hope to be doing 12 weeks as I am tx naive and 3 weeks b4 i started treatment my fibroscan was 10.4, so no cirrhosis. Time will tell. Mesochem makes a generic Harvoni?
HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL
8 weeks tx ALT 29/ AST 34. VL UND
4 weeks after tx UND. SVR4. ALT 24/AST 18

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cheat sheet 6 years 10 months ago #6344

London Girl,
You saw the original cheat sheet they have posted here, right? Not just the explanation Dr. Freeman gave in this thread? It is more detailed, I believe...
HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL
8 weeks tx ALT 29/ AST 34. VL UND
4 weeks after tx UND. SVR4. ALT 24/AST 18

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cheat sheet 6 years 10 months ago #6345

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Mesochem makes API powders. They Make Sofosbuvir and they make Ledipasvir. These are the two APIs in Harvoni.
The following user(s) said Thank You: kenbasman, poodle

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cheat sheet 6 years 10 months ago #6359

Hi kenbasman, Yes I did, but thanks for checking for me, appreciated.
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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cheat sheet 6 years 10 months ago #6361

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Thanks Kenbasman and thanks Alsdad for answering the mesochem question
Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
24weeks mesochem sof/led as unsure of fibrosis status.
currently UND. No bad side effects
Have svr12 ... waiting for svr 24
I now have SVR 36 weeks.

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