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TOPIC: Dac and Led interactions

Dac and Led interactions 6 years 4 months ago #6392

  • dointime
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I have been looking at the prescribing information here:
fixhepc.com/forum/forum-gp-cheat-sheet.html

"Medications (Daclatasvir and Ledipasvir in particular have many interactions) you can check with this tool www.hep-druginteractions.org/checker

I checked with the tool and it is not showing any interactions for dac and led. It's giving a green light.

So which is correct?
Thanks,
dt
Last Edit: 5 years 10 months ago by Hieupham.
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Dac and Led interactions 6 years 4 months ago #6393

  • dointime
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Oh duh! I see that the prescribing info meant that both dac and led have many interactions with OTHER drugs.
I was thinking it meant they have many interactions with EACH OTHER.

Anyway, I am still unclear on the subject of whether dac and led have interactions with each other. I cannot find any information which suggests that they do. I also cannot find any evidence which proves that they don't. I want to know if the concentration of either drug will be lowered by the presence of the other during a switchover from led to dac, while keeping sof the same?

Possibly this is still one of the many as yet unanswered questions about using the DAAs.

dt
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Dac and Led interactions 6 years 4 months ago #6394

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PS
I meant to say "efficacy', not "concentration" which may not be the same thing.
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Dac and Led interactions 6 years 4 months ago #6397

  • Gaj
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I suspect there is little research on what you are asking as:

- It would require crosslabel trials which tend to be expensive.
- the standard treatment approach seems to be to use one NS5A inhibitor thoughout treatment and if that treatment fails to retreat preferably using another NS5A inhibitor that expresses itself via a different path if such an drug exists. This would apparently reduce any risk of resistance effecting the retreatment. I don't know whether Dac and Led differ sufficiently to do that or whether they are entirely analogous.

I'm not a scientist just an interested reader so the above is just my take on it.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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