TOPIC:

Have a look at this:

www.researchgate.net/publication/2591130..._and_ex-vivo_studies

Hear you on that, Pheonix. And I just found out the supposedly 100% whey protein I've been taking, wasn't (soy lecithin, in very small type lol) Only found one brand today which promised NO soy, well fingers crossed.

Few other herbal/supplements too

fixhepc.com/forum/drug-interactions/329-...ver-safety.html#3028

I eat a lot of Miso...soy is very different when its fermented.
Normal soy I avoid anyway...it's mostly pretty toxic....but Miso...
Do I need to forgo it on Dac? And Led as well?
I might choose Led if I can still eat Miso.

Hi FlyingFox, I don't think we can draw definite conclusions yet. I have miso in the fridge too, and I decided not to have it for lunch today. But the link I posted was to a solitary study on rats, and I've only seen the summary page. I've seen soy described as an inhibitor elsewhere, which wouldn't be so bad (if you want to dose up).

I think we need to hear more from the medical and scientific people on the forum...

Seems not, fox (speaking tentatively)

Both sofosbuvir and ledipasvir are not metabolized by the cytochrome P450 system of enzymes but rather are substrates for p-glycoprotein.

www.ncbi.nlm.nih.gov/pubmed/25553890

Zhuk the concerns about CYP3A4 relate to Daclatasvir.

Sorry Zhuk didn't notice Flyingfox was talking about Led.

I haven't started treatment yet so I'm still trying to choose.
Daclatasvir seems to be contraindicated for a few of my favourite things.

personally I'm happy to give up lots of favourite things for 12 weeks. But I don't want to convince you either way. Best talk to experts.

Hey Flying Fox!!!!

I've been eating miso during 8 months before TX....Fantastic...! I stopped eating Macrobiotics on TX because it wasn't possible anymore...Every tissue in your body will change...so...to me eating healthy was a difficult thing to do because all this years I ate so strict!!.....BUT Miso is full of omega and you should not eat that with TX....I don't know...Miso is such an intestins-cleaner....I don't do it...You will not be able to control your appetite anyways ....Good luck!

flyingfox66 wrote: I eat a lot of Miso...soy is very different when its fermented.
Normal soy I avoid anyway...it's mostly pretty toxic....but Miso...
Do I need to forgo it on Dac? And Led as well?
I might choose Led if I can still eat Miso.

Hey! he TX will take control of your appetite anyways...Once you start TX, a lot of powerful things will be happening on a physical, emotional, spiritual level....With all this happening your body will need more calories and stuff...I've been very disciplined all these years...And on TX: uncontrolable LOL

Phoenix wrote: personally I'm happy to give up lots of favourite things for 12 weeks. But I don't want to convince you either way. Best talk to experts.

Interesting...omegas are not good on Tx?
Thats really why I am concerned about Miso...its my probiotic (I use unpasteurised).
Maybe once my digestion comes back on line I won't need it so much.
I'm not hugely strict diet wise, though I always prefer fresh food.
Rich food has made me feel sick for years and years now. Be funny if that changes. I might get fat!

I'm battling that myself ff66,

All the foods I couldn't eat previously look, smell and taste delicious now. I use to have to make myself eat at mealtimes to keep condition. Now, I find I want to eat all day!

Ah well hopefully we'll have so much energy we'll be able to run around to burn it all off

Well yes, but all that exercise just makes me even hungrier. I am feeling fitter though.