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TOPIC: Soy an inducer of CYP3A4 ?

Soy an inducer of CYP3A4 ? 6 years 4 months ago #6948

Phoenix Offline Senior Member Posts: 72 Thank you received: 84 Karma: 2	Have a look at this: https://www.researchgate.net/publication/259113039_Potential_modulation_on_P-glycoprotein_and_CYP3A_by_soymilk_and_miso_In_vivo_and_ex-vivo_studies
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #6964

zhuk Offline Platinum Member Posts: 551 Thank you received: 502 Karma: 3	Hear you on that, Pheonix. And I just found out the supposedly 100% whey protein I've been taking, wasn't (soy lecithin, in very small type lol) Only found one brand today which promised NO soy, well fingers crossed. Few other herbal/supplements too http://fixhepc.com/forum/drug-interactions/329-herbs-and-liver-safety.html#3028
	GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 Last Edit: 6 years 4 months ago by zhuk. The administrator has disabled public write access.

Soy an inducer of CYP3A4 ? 6 years 4 months ago #6968

flyingfox66 Offline Elite Member Posts: 172 Thank you received: 214 Karma: 0	I eat a lot of Miso...soy is very different when its fermented. Normal soy I avoid anyway...it's mostly pretty toxic....but Miso... Do I need to forgo it on Dac? And Led as well? I might choose Led if I can still eat Miso.
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #6969

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Hi FlyingFox, I don't think we can draw definite conclusions yet. I have miso in the fridge too, and I decided not to have it for lunch today. But the link I posted was to a solitary study on rats, and I've only seen the summary page. I've seen soy described as an inhibitor elsewhere, which wouldn't be so bad (if you want to dose up).

I think we need to hear more from the medical and scientific people on the forum...

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Soy an inducer of CYP3A4 ? 6 years 4 months ago #6970

zhuk Offline Platinum Member Posts: 551 Thank you received: 502 Karma: 3	Seems not, fox (speaking tentatively) Both sofosbuvir and ledipasvir are not metabolized by the cytochrome P450 system of enzymes but rather are substrates for p-glycoprotein. https://www.ncbi.nlm.nih.gov/pubmed/25553890
	GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 The administrator has disabled public write access. The following user(s) said Thank You: flyingfox66

Soy an inducer of CYP3A4 ? 6 years 4 months ago #6973

Phoenix Offline Senior Member Posts: 72 Thank you received: 84 Karma: 2	Zhuk the concerns about CYP3A4 relate to Daclatasvir.
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #6974

Phoenix Offline Senior Member Posts: 72 Thank you received: 84 Karma: 2	Sorry Zhuk didn't notice Flyingfox was talking about Led.
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #6977

flyingfox66 Offline Elite Member Posts: 172 Thank you received: 214 Karma: 0	I haven't started treatment yet so I'm still trying to choose. Daclatasvir seems to be contraindicated for a few of my favourite things.
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #6978

Phoenix Offline Senior Member Posts: 72 Thank you received: 84 Karma: 2	personally I'm happy to give up lots of favourite things for 12 weeks. But I don't want to convince you either way. Best talk to experts.
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #7002

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Hey Flying Fox!!!!

I've been eating miso during 8 months before TX....Fantastic...! I stopped eating Macrobiotics on TX because it wasn't possible anymore...Every tissue in your body will change...so...to me eating healthy was a difficult thing to do because all this years I ate so strict!!.....BUT Miso is full of omega and you should not eat that with TX....I don't know...Miso is such an intestins-cleaner....I don't do it...You will not be able to control your appetite anyways

....Good luck!flyingfox66 wrote:

I eat a lot of Miso...soy is very different when its fermented.
Normal soy I avoid anyway...it's mostly pretty toxic....but Miso...
Do I need to forgo it on Dac? And Led as well?
I might choose Led if I can still eat Miso.

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Soy an inducer of CYP3A4 ? 6 years 4 months ago #7004

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Hey! he TX will take control of your appetite anyways...Once you start TX, a lot of powerful things will be happening on a physical, emotional, spiritual level....With all this happening your body will need more calories and stuff...I've been very disciplined all these years...And on TX: uncontrolable LOL

Phoenix wrote:

personally I'm happy to give up lots of favourite things for 12 weeks. But I don't want to convince you either way. Best talk to experts.

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Soy an inducer of CYP3A4 ? 6 years 4 months ago #7023

flyingfox66 Offline Elite Member Posts: 172 Thank you received: 214 Karma: 0	Interesting...omegas are not good on Tx? Thats really why I am concerned about Miso...its my probiotic (I use unpasteurised). Maybe once my digestion comes back on line I won't need it so much. I'm not hugely strict diet wise, though I always prefer fresh food. Rich food has made me feel sick for years and years now. Be funny if that changes. I might get fat!
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #7024

Gaj Offline Moderator Optimist :-) Posts: 1436 Thank you received: 3082 Karma: 32	I'm battling that myself ff66, All the foods I couldn't eat previously look, smell and taste delicious now. I use to have to make myself eat at mealtimes to keep condition. Now, I find I want to eat all day!
	G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The administrator has disabled public write access.

Soy an inducer of CYP3A4 ? 6 years 4 months ago #7025

flyingfox66 Offline Elite Member Posts: 172 Thank you received: 214 Karma: 0	Ah well hopefully we'll have so much energy we'll be able to run around to burn it all off
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Soy an inducer of CYP3A4 ? 6 years 4 months ago #7027

Gaj Offline Moderator Optimist :-) Posts: 1436 Thank you received: 3082 Karma: 32	Well yes, but all that exercise just makes me even hungrier. I am feeling fitter though.
	G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The administrator has disabled public write access. The following user(s) said Thank You: zhuk