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Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8152
| I've just finished 12 weeks of a 24 week treatment with Sof & Led. I was also taking Ribavirin for the first 12 weeks but from now on its only Sof & Led. I had a few side effects from the RIBA but I'm not sure what to expect with just the Sof & Led. I guess in about 12 to 14 days, the RIBA should be out of the body. Can anyone tell me what, if any side effects they're getting on just the Sof & Led ? Male aged 66, contracted hepC 45 years ago Failed treatment interferon and Ribavarin 2003 Started treatment 22 October 2015, 24 week, Dr Freeman Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin Geno 1a Fibrosis F3/4 VL <12 at 4 weeks VL - negative at 12 weeks |
Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8159
Hi Hamilton, I suspect you are just going to keep feeling better and better throughout the rest of treatment and certainly notice nothing worse than now. Riba has a half life of 12.4 days so after 84 days of use to date you are saturated with it. It will now drop to half the level in 12.4 days, quarter the level at ~25 days, one eighth at 37 days, one sixteenth at 50 days, etc. www.drugs.com/pro/ribavirin.html "In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months." G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The following user(s) said Thank You: DrJames | |
Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8160
| Hi Hamilton I have three weeks to go of a 12 week course on Sof/Led. Only side effect was insomnia which resolved itself about half way through my treatment. Feeling much better now than before I started. Good luck with the rest of your treatment Lives in Bendigo, Victoria No prior treatment Genotype 1b Fibroscan 0 (only showed a bit of a fatty liver) Diagnosed in February 2015 Currently on my last week of treatment taking led/sof Last LFT normal Insomnia the only side effect Undetected at 4 weeks SVR4 - undetected - all bloods good and GP very happy SVR12 bloods to be done at end of April 2016 SVR12 - undetected!!! |
Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8164
| Hi Hamilton, I am 1 week in and so far sx very manageable. 1st day, mild 'hangover-like ' headache - drank water & it went, no more headaches since. Speedy mornings after taking pill & amazing 'flashes' of feeling my old self - Day 2 Tinitus a little more pronounced but not bad. After a week - Less sleep. Go to sleep ok but waking up earlier every morning. Lower back/pelvic/hip pain returned, but not disabling, just 'there'.(instinct says digestive/lower bowel, not frame/muscle) Huge appetite - Think I'm putting on much needed weight! Aware I am emotionally sensitive to anything sad or stressful, but more cheery in general - no doubt. Oh yeah, sudden brain -fog episodes, worse in evening All in all, it's very easy GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8196
You probably got the worst of the side effects from the Sof/Led out of the way while you were on combination with the Riba, Hamilton. It should be plain sailing once you've cleared the Riba. | |
Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8281
| Thanks GAJ, Lynee, London Girl & Alsdad for your information. This has given me lots of encouragement to push on. Male aged 66, contracted hepC 45 years ago Failed treatment interferon and Ribavarin 2003 Started treatment 22 October 2015, 24 week, Dr Freeman Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin Geno 1a Fibrosis F3/4 VL <12 at 4 weeks VL - negative at 12 weeks The following user(s) said Thank You: LondonGirl, Lynne-Francis-facebook |
Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8378
Starting my 3rd week on generic harvoni. No major side effects although my bile reflux became worst upon starting the harvoni. This was remedied by using Urosan. I don't feel any better since using Harvoni but that's to be expected as its not supposed to make you feel better. Its job is to destroy the virus - liver damage will remain the same - there's no cure for cirrhosis Diagnosed Hep C 2013 Geno Type: 1a Treatment: Naïve Cirrhosis F4 2015 GGT 227 AST 79 ALT 89 Platelets 88 2016 Treatment Generic Harvoni Finished 29 March 2016 GGT 30 AST 19 ALP 67 Platelets 91 Qualitative Test Results April 12 Hepatitis C NAT (NA): Not Detected P.C.R Test for Hep C 4th July: Negative Virus Free This email address is being protected from spambots. You need JavaScript enabled to view it. | |
Sofosbuvir & Ledipasvir Treatment 8 years 6 months ago #8457
| Thank for that Stew, I've heard that your liver is the only organ that can repair itself. I'm hoping to clear the virus & my liver will slowly repair. Like you Stew, I've been having problems with my reflux. Went off my SOMAC before start of treatment. Male aged 66, contracted hepC 45 years ago Failed treatment interferon and Ribavarin 2003 Started treatment 22 October 2015, 24 week, Dr Freeman Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin Geno 1a Fibrosis F3/4 VL <12 at 4 weeks VL - negative at 12 weeks |
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