emo Sofosbuvir & Ledipasvir Treatment

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6 years 5 months ago #8152

I've just finished 12 weeks of a 24 week treatment with Sof & Led.
I was also taking Ribavirin for the first 12 weeks but from now on its only Sof & Led.
I had a few side effects from the RIBA but I'm not sure what to expect with just the Sof & Led.
I guess in about 12 to 14 days, the RIBA should be out of the body.
Can anyone tell me what, if any side effects they're getting on just the Sof & Led ?


Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL - negative at 12 weeks

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6 years 5 months ago #8159

Hi Hamilton,

I suspect you are just going to keep feeling better and better throughout the rest of treatment and certainly notice nothing worse than now. Riba has a half life of 12.4 days so after 84 days of use to date you are saturated with it. It will now drop to half the level in 12.4 days, quarter the level at ~25 days, one eighth at 37 days, one sixteenth at 50 days, etc.

www.drugs.com/pro/ribavirin.html "In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months."


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: DrJames

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6 years 5 months ago #8160

Hi Hamilton I have three weeks to go of a 12 week course on Sof/Led. Only side effect was insomnia which resolved itself about half way through my treatment. Feeling much better now than before I started. Good luck with the rest of your treatment :)


Lives in Bendigo, Victoria
No prior treatment Genotype 1b Fibroscan 0 (only showed a bit of a fatty liver) Diagnosed in February 2015 Currently on my last week of treatment taking led/sof Last LFT normal
Insomnia the only side effect
Undetected at 4 weeks
SVR4 - undetected - all bloods good and GP very happy
SVR12 bloods to be done at end of April 2016
SVR12 - undetected!!!

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6 years 5 months ago #8164

Hi Hamilton, I am 1 week in and so far sx very manageable.

1st day, mild 'hangover-like ' headache - drank water & it went, no more headaches since.
Speedy mornings after taking pill & amazing 'flashes' of feeling my old self - Day 2 #woohoo!
Tinitus a little more pronounced but not bad.
After a week - Less sleep. Go to sleep ok but waking up earlier every morning.
Lower back/pelvic/hip pain returned, but not disabling, just 'there'.(instinct says digestive/lower bowel, not frame/muscle)
Huge appetite - Think I'm putting on much needed weight!
Aware I am emotionally sensitive to anything sad or stressful, but more cheery in general - no doubt.
Oh yeah, sudden brain -fog episodes, worse in evening

All in all, it's very easy :-) You should feel so much better soon Hamilton .


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
Last Edit: 6 years 5 months ago by LondonGirl.

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6 years 5 months ago #8196

You probably got the worst of the side effects from the Sof/Led out of the way while you were on combination with the Riba, Hamilton. It should be plain sailing once you've cleared the Riba.

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6 years 5 months ago #8281

Thanks GAJ, Lynee, London Girl & Alsdad for your information.
This has given me lots of encouragement to push on.


Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL - negative at 12 weeks
The following user(s) said Thank You: LondonGirl, Lynne-Francis-facebook

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6 years 5 months ago #8378

Starting my 3rd week on generic harvoni.
No major side effects although my bile reflux became worst upon starting the harvoni. This was remedied by using Urosan.
I don't feel any better since using Harvoni but that's to be expected as its not supposed to make you feel better. Its job is to destroy the virus - liver damage will remain the same - there's no cure for cirrhosis


Diagnosed Hep C 2013
Geno Type: 1a
Treatment: Naïve
Cirrhosis
F4
2015 GGT 227 AST 79 ALT 89 Platelets 88
2016 Treatment Generic Harvoni Finished 29 March 2016
GGT 30 AST 19 ALP 67 Platelets 91
Qualitative Test Results April 12
Hepatitis C NAT (NA): Not Detected
P.C.R Test for Hep C 4th July: Negative
Virus Free
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6 years 5 months ago #8457

Thank for that Stew,
I've heard that your liver is the only organ that can repair itself.
I'm hoping to clear the virus & my liver will slowly repair.
Like you Stew, I've been having problems with my reflux.
Went off my SOMAC before start of treatment.


Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL - negative at 12 weeks

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