emo Things to avoid on treatment?

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6 years 6 months ago #9820

Can anyone give advice on the following; Avoiding fats while on daclatasvir? Am I ok to carry on with nicotine replacement while on tx and anything else to avoid? I am aware of avoiding grapefruit. thanks.


gt3 started sof dac jan 2016 now 48 wks svr. not the real wilko johnson just have the same real name. shropshire uk
Last Edit: 6 years 6 months ago by wilko johnson.

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6 years 6 months ago #9823

Hey Wilko :)
Seville oranges and I think, marmalade. The best of luck with your treatment, so pleased that you are finally sorted :+1:


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
Last Edit: 6 years 6 months ago by LondonGirl.
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6 years 6 months ago #9825

Hi Wilko,

Couple of threads about things to avoid on Daclatasvir, just be aware in the second one that only the first four fruits are really a problem and garlic is probably since disproved but just don't eat several raw cloves at the same time as the Dac.

fixhepc.com/forum/drug-interactions/108-...ractions-cyp3a4.html

www.ganfyd.org/index.php?title=Inhibitors_of_CYP3A4

Regarding fats, there are some warnings about that going around but the only research I've seen involved taking it directly after a meal containing very high fat (from memory +30-40g?) in which case not as much was absorbed by your body. They suggested it wouldn't be a problem on normal diets. You can take Sof & Dac with or without food so if with then just make it a low fat meal. OTOH Ribavirin should be taken with some fat, in which case you may want to take It at a different time to the other meds.


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 6 years 6 months ago by Gaj.
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6 years 6 months ago #9828

Thanks Gaj, I'me taking my meds in the mornings, no riba required for me. So I can have double cream on me pud at evening meal!! Thats great , and I do like me gaalic in my cooking, usually at evening meal too. Cheers.


gt3 started sof dac jan 2016 now 48 wks svr. not the real wilko johnson just have the same real name. shropshire uk

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6 years 6 months ago #9899

Great news they have Arrived at last..............:)

Hopefully, you have a easy time whilst on treatment I have my fingers crossed for you.

In no time you'll be joining us on the Undetected bench and soon after cured.

Good luck.


Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
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