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TOPIC: Update on treatment after relapse
Update on treatment after relapse 2 years 11 months ago #22997
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I have just passed the 12 week mark on my second treatment (of 24 weeks) so I thought it was time to post an update. I relapsed after my first treatment at a time when many people were waiting for SVR results and knowing how much anxiety the thought of relapsing can cause I decided to keep things pretty low key. Now that some people have already commenced or are seeking re-treatment I think it's pretty important to get it out there.
My bio gives my history of being a slow responder and then a relapser. I had another consultation with Dr Freeman through GP2U and commenced my second treatment (Viekira Pak, Solvadi and Ribavirin) on 3/9/16. A week after I started this treatment my father's condition (prostate cancer) declined so I flew interstate and spent his final few weeks with him. It was a crazy time and my family were great in reminding me to take my medication. I did make myself sick once from trying to make up for missed tablets and getting dehydrated but Dr F helped to calm me down and get me back on the path. Although my Dad didn't live long enough to see me cured I did receive an email from Dr F while I was at my Dad's 'wake' telling me that the results of my 3 week blood test showed that my liver functions (AST/ALT) had returned to normal already. We toasted that as well as my Dad! My 9 week results showed UNDETECTED so the bigger guns have worked well!! I breezed through my first treatment with Sof/Led and Sof/Dac with minimal side effects. This second treatment has been a little tougher, probably due to the Ribavirin. I had major headaches initially but have found that I can minimise these if I make sure I drink enough water. I have had trouble sleeping and major dry skin and hair but although these are frustrating they're not unbearable. I knew when the virus had gone during the first treatment, knew when it came back and know that it is gone again now. Relapsing is devastating but there are other options and mine is working well for me. I've been keeping an eye on my friends here who are starting their next treatment or have to wait a little longer (looking at you Gaj) and look forward to hearing your results second time around. Thanks as always to Dr F and for everyone's support. Reading about the stories and the good news of others really does help. So I have another 12 weeks to go. So far so good and hopefully it will be second time lucky.  |
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G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back! New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217. SVR12 and SVR 24... |
Update on treatment after relapse 2 years 11 months ago #22998
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Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!! Harvoni treatment, started 19 March 2016 4 week results Bilirubin 12 down from 14 pre treatment, Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47, VL <15 down from a lazy 6 million or so EOT Results Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND 12 Weeks post EOT Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND Cured baby |
Update on treatment after relapse 2 years 11 months ago #22999
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Dear Coral, So happy to hear your labs are normal, and VL undetected at 9 weeks. The next 12 weeks should go by quickly. The headaches and insomnia seem to affect many, myself included...So sorry to hear about your father's illness and passing..Thank you for your post. Wishing you best of luck with your treatment...Hopes and prayers for you to reach SVR this time!.....
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HCV since 35-40yrs., GT 1a , Dx 2004; VL 4-5 mil, F2-3
Tx sof/led started 3/4/16 4wks VL <15 9 weeks VL UND, ; Alt-15,Ast-13 16 weeks VL UND Alt-20, Ast-22; EOT 24 wks UND SVR 4 UND SVR 12 UND, Alt.15, Ast. 17 SVR 24 UND |
Update on treatment after relapse 2 years 11 months ago #23001
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Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32 4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35 6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15 8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND 12 Week Results 31 August, 2016 LFTs Normal, VL = UND EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4" SVR12, 21 Nov 2016. CURED!!! |
Update on treatment after relapse 2 years 11 months ago #23002
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Hi Coral,
Congratilations on getting succesfully. halfway trough your treatment. After failing previous treatment I can relate to this, it's soo0 tough. But you seem soo determined  With all my  , best of luck with your difficult journey back to health !!Sorry for your lost, be strong and don't loose youself into the pain... |
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Genotype 1b, VL before TX:325 000,ALT41, AST41, F2
2004 INT/Rib,stopped after 5 months, due to severe side effects SOFOSBUVIR+LEDIPASVIR from India Hepcvir-L /generic Harvoni beginning of treatment :12/07/2016, Feeling OK 4 weeks AST 22, ALT 23 VL undetected 8 weeks AST 29, ALT 22.VL undetected 3/10/2016 EOT EOT + 4 Weeks, LFTs Normal, VL = UND |
Update on treatment after relapse 2 years 11 months ago #23003
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Good luck this time arounf Coral. I know it will be good news......
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Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James |
Update on treatment after relapse 2 years 11 months ago #23005
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Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16 6 wk. labs, VL UND, AST 27, ALT 20 EOT labs, VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24, VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 |
Update on treatment after relapse 2 years 11 months ago #23008
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Thanks for your kind thoughts Beaches, Fara, Fitz and Murr. It means a lot.
Splitdog - thanks - you're on my watch list! Greedfighter - thanks. I know, Dr Freeman is quite extraordinary. It's hard to know quite how to reward someone who gives you your life back. |
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G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back! New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217. SVR12 and SVR 24... |
Update on treatment after relapse 2 years 11 months ago #23011
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Dear Coral
Thank you for sharing your treatment updates and congratulations on reaching halfway through and the riba. I send you condolences for your loss of your dad as a daddy's girl I feel deep pain over loss for a daughter of her father. My own died 11 years ago but it still feels like yesterday. Pat1 lost her dear dad during her tx it's somewhere in the maze of forum posts and I know it was tough. You are one strong woman facing up to retreating and family loss. The courage you take forward will be forever and that's something not many people have. I think people who have fought this illness hard are really amazing in many ways, learning to ride out bad news, rejoicing in good news, uplifting others, reading insightfully between the written or spoken words to the heart of the real person. I'm sure serious illness across all types has a profound effect on most people who have walked in our shoes and it's only good. Affirmation of the strength it takes is so important. Sending love and huge splashes of happies on your halfway mark, and look forward to your updates Coral Love from Ariel Last night we enjoyed an amazing sunset which I managed to capture on my iPhone as I drove home from the hospital and I share it with you it's so inspiring 
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Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas. pre sof/led VL 240,000 Fibsc F0 Day 25 <30 Day 32 UND Week 10 UND EOT UND ALT11AST17GGT19 SVR4 UND ALT10 AST16 GGT13 SVR8 UND ALT <9 AST16 GGT15 SVR12 UND ALT14 AST19 GGT12 Bili 5 EOT +18 ALT13 AST20 GGT9 Bili 5 EOT +21 ALT11AST15 Cured SVR12 Dysplasia Adenomas RemvdAug '16 SVR24 UND ALT11AST16 ColonoscopyClear Nov17 LumpectomyClear ‘18 LithotripsyCytoscopyBiopsy 4/18 |
Update on treatment after relapse 2 years 11 months ago #23019
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Hi coral
, Good to hear you're feeling positive and UND Have been thinking of you and wishing you the best result this 2nd time round. UND at 9 weeks? another 15 weeks of blitzing should see any stragglers off for good. Was sad to read of the loss of your Dad, it's been a long haul turbulent time for you, keep strong, it should all be over with in a few months You know where I am if you need a listening ear x |
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GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
Update on treatment after relapse 2 years 11 months ago #23052
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Ariel and LG - thanks so much for your messages. What courageous, gorgeous women you are
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G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back! New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217. SVR12 and SVR 24... |
