emo spontaneous reduction of viral load ?

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5 years 9 months ago #22654

Before I started treatment I had 2 viral load tests with 2 weeks space between them. First one was about 440 000 IU and second one was 673.62 fmol/l. When transferred into previous test's units it is about 60 000. I suppose it goes up and down according to the balance between immune system and virus. Question was whether 7fold decrease in viral quantity without treatment is unusual or not.
Thank you for any info


Diagnosed September 2016.
1b
ALAT in 40s.
VL 460 000
Fibroscan 12.5
Start of treatment 18/10/16
Wk 2 VL 145
Wk 4 VL detected unquantifiable
Wk 8 VL detected unquantifiable
Wk 12 undetected
week 30 after eot - undetected

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5 years 9 months ago #22658

Hello countless,

The tests for core antigen and PCR RNA are only roughly comparable so some of the difference will simply be due to that.

Although PCR results get reported like 1,234,567 suggesting great accuracy depending on the test the accuracy is nothing like that.

Different tests report different results, and even the same test, repeated on the same sample will have a standard deviation of something like 0.1-0.2 log. While 0.2 log might not sound like much in statistical terms 95% of results appear within 2 standard deviations of the mean. In English if the standard deviation is 0.2 log and the result is log 6 (ie 1 million) then we might see any of the following results for a retest of the same sample using the same test

2 SD below = log 5.6 = 398,000
1 SD below = log 5.8 = 763,000
0 SD = log 6 = 1,000,000
1 SD above = log 6.2 = 1,584,000
2 SD above = log 6.4 = 2,515,000

Add that to the observed reality that viral load goes up and down over time quite naturally and there is no significance to this other than to say you definitely have Hep C and the viral load is relatively low (the average load is 1-3 million)


YMMV
The following user(s) said Thank You: Gaj

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5 years 9 months ago #22659

Thank you ! A week ago it was 145 only so now it probably is 0 and I no longer have it. Thank you for that as well.
Now only seeing what will be left from my career and liver.


Diagnosed September 2016.
1b
ALAT in 40s.
VL 460 000
Fibroscan 12.5
Start of treatment 18/10/16
Wk 2 VL 145
Wk 4 VL detected unquantifiable
Wk 8 VL detected unquantifiable
Wk 12 undetected
week 30 after eot - undetected
The following user(s) said Thank You: DrJames, Gaj

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