Welcome, Guest
Username: Password: Remember me

TOPIC: Detected at EOT? virus may be uninfectious,

Detected at EOT? virus may be uninfectious, 6 years 4 months ago #7520

  • Enkel
  • Enkel's Avatar
  • Offline
  • Platinum Member
  • Posts: 329
  • Thank you received: 165
  • Karma: 0
It is intersting that with the regiment including sofosbuvir, Detected at EOT still have higher cure rate

"There must be other reasons to explain the high SVR," Guedj said. "We think most of the [newly produced] virus may be uninfectious...treatment may have the effect of replacing a working replication complex with a defective replication complex, which explains how most patients could clear the virus in 6 weeks."

"Low negative predictive values of HCV RNA at week 4 underscore the importance of continued therapy for patients who fail to achieve undetectable levels of HCV RNA early on during treatment because the likelihood of achieving SVR12 is still high," the researchers concluded. "Contrary to past experience with interferon-containing treatments, the presence of detectable HCV RNA at EOT [end of treatment] is not predictive of relapse in these studies."

www.aidsmap.com/HCV-viral-load-levels-du...herapy/page/2962856/

An uninfectious virus may only explain these data of this person:
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result: Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22
48 wk post tx: UNDETECTED SVR48
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
Last Edit: 6 years 4 months ago by Enkel.
The administrator has disabled public write access.
The following user(s) said Thank You: Alsdad, dointime, Price, Gaj, zhuk, splitdog

Detected at EOT? virus may be uninfectious, 6 years 4 months ago #7526

  • Dan
  • Dan's Avatar
  • Offline
  • Elite Member
  • Posts: 203
  • Thank you received: 154
  • Karma: 0
This is very interesting. Thanks Enkel for you research.
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
The administrator has disabled public write access.

Detected at EOT? virus may be uninfectious, 6 years 4 months ago #7528

  • Enkel
  • Enkel's Avatar
  • Offline
  • Platinum Member
  • Posts: 329
  • Thank you received: 165
  • Karma: 0
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
The administrator has disabled public write access.
Time to create page: 0.073 seconds

Copyright © 2015-2020 FixHepC

Back to Top