Home Forums Main Forum FixHepC Admin Q & A cheat sheet

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  • #7385
    Avatar photokenbasman
    • Guardian Angel
    • ★★★★★
    @kenbasman

    Hi there,
    I managed to get myself Lesovir-C brought back to me from Bangladesh almost 2 weeks ago and as I am in the middle of Mexico and basically self treating I was hoping somebody could answer me a couple of questions that are on the cheat sheet. Out of the following sentence…

    4/52 into treatment FBC, Cr&E, LFTs, Hep C Viral Load

    …I am not clear on 4/52, Cr&E and LFTs. I assume FBC is Full Blood Count and viral load i get.
    Thanks in advance to anyone who can clear this up for me,
    Ken


    HCV 35 yrs G1a F3 Tx naive
    started Lesovir-C 15/12/2015
    pre tx: VL 5,250,000 ALT 374 AST 208
    FIBROSCORE 10.4

    4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18

    #7391
    Avatar photopat1
    • Guardian Angel
    • ★★★★★
    @pat1

    Hi Ken

    I copied this info from previous threads by using the search function. I hope this helps and all the best with tx in Mexico.

    FBC Full Blood Count and LFT Liver Function Test

    CR&E Urea, Electrolytes, Creatine

    4/52 is doctor code for 4 weeks

    8/52 would be 8 weeks

    Lin


    gt 1a VL 6m
    F2/3 FibroScan – 9KPa in 2011 and 7KPa in 2015
    sof/dac 10 December for 12 weeks
    pre tx alt 85 ast 51
    4 wk alt 34 ast 31 UND <35
    8 wk alt 29 ast 32 UND <15
    12wk alt 25 ast 25 EOT 3.3.16
    SVR24 UND KPa5.3 F0 in normal range
    I am well
    .forever grateful to fixhepc

    #7393
    Avatar photokenbasman
    • Guardian Angel
    • ★★★★★
    @kenbasman

    .Thanks Lin,
    I will start posting my results from the Lesovir-C as soon as I have some new info. It doesn’t get as much “airtime” here as the twinvir. All iI know is that so far, after 13 days of tx, i hav had no side effects and for the last 4 days I have flelt better than I have in years. I am genotype 1a. F3 on my last fiboscan. Viral load around 5,500,000. Enzymes about 10x what they should be.
    See what the test results come back as this week,
    Ken


    HCV 35 yrs G1a F3 Tx naive
    started Lesovir-C 15/12/2015
    pre tx: VL 5,250,000 ALT 374 AST 208
    FIBROSCORE 10.4

    4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18

    #7403
    Avatar photopoodle
    • Guardian Angel
    • ★★★★★
    @poodle

    Hi I have similar status as you , but using mesochem .Will you be doing 12 or 24 weeks. Good luck. Jill


    Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
    24weeks mesochem sof/led as unsure of fibrosis status.
    currently UND. No bad side effects
    Have svr12 … waiting for svr 24
    I now have SVR 36 weeks.

    #7404
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello kenbasman,

    Essentially you don’t strictly require any monitoring unless you get unwell but:

    4/54 == 4 weeks post starting treatment

    FBC = Full Blood Count = CBC = Complete Blood Count
    Cr&E = Creatinine & Electrolytes = UEC = Urea Electrolytes Creatinine
    LFTs = Liver Function Tests like Bilirubin, ALP, AST, GGT, Albumin
    Hep C Viral Load = Quantitative HCV RNA

    The 4 week test typically shows (80%) viral load zero and proves the meds are valid and working.

    If you want an early proof your AST will fall rapidly back to normal

    Once viral load is zero there is really not a lot of need for further monitoring (unless on Ribavirin)

    The 12 weeks versus 24 weeks length decision is based on Fibrosis. If you have cirrhosis (F4, > 14 kPa, Hepascore > 0.5) then you need 24 weeks.

    Next test after viral load zero can be SVR4 or SVR12 – Viral load 4 or 12 weeks post finishing treatment, and a VL=0 at 4 weeks = 96% chance of cure, and at 12 weeks 99% chance.


    YMMV

    #7405
    Avatar photokenbasman
    • Guardian Angel
    • ★★★★★
    @kenbasman

    Thanks Doc!


    HCV 35 yrs G1a F3 Tx naive
    started Lesovir-C 15/12/2015
    pre tx: VL 5,250,000 ALT 374 AST 208
    FIBROSCORE 10.4

    4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18

    #7421
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    I told my GP about the cheat sheet, he looked extremely interested and jotted down the url. :)


    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    #7423
    Avatar photokenbasman
    • Guardian Angel
    • ★★★★★
    @kenbasman

    Jill,
    I hope to be doing 12 weeks as I am tx naive and 3 weeks b4 i started treatment my fibroscan was 10.4, so no cirrhosis. Time will tell. Mesochem makes a generic Harvoni?


    HCV 35 yrs G1a F3 Tx naive
    started Lesovir-C 15/12/2015
    pre tx: VL 5,250,000 ALT 374 AST 208
    FIBROSCORE 10.4

    4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18

    #7424
    Avatar photokenbasman
    • Guardian Angel
    • ★★★★★
    @kenbasman

    London Girl,
    You saw the original cheat sheet they have posted here, right? Not just the explanation Dr. Freeman gave in this thread? It is more detailed, I believe…


    HCV 35 yrs G1a F3 Tx naive
    started Lesovir-C 15/12/2015
    pre tx: VL 5,250,000 ALT 374 AST 208
    FIBROSCORE 10.4

    4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18

    #7425
    Avatar photoAlsdad
    • Guardian Angel
    • ★★★★★
    @alsdad

    Mesochem makes API powders. They Make Sofosbuvir and they make Ledipasvir. These are the two APIs in Harvoni.

    #7439
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Hi kenbasman, Yes I did, but thanks for checking for me, appreciated.


    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    #7442
    Avatar photopoodle
    • Guardian Angel
    • ★★★★★
    @poodle

    Thanks Kenbasman and thanks Alsdad for answering the mesochem question


    Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
    24weeks mesochem sof/led as unsure of fibrosis status.
    currently UND. No bad side effects
    Have svr12 … waiting for svr 24
    I now have SVR 36 weeks.

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