Hi Dr Freeman,

I am looking at the ‘Nearly one-third of patients with previous HCC recur after DAA therapy April 14, 2016’.

This article that in the middle states:

1. “A history of previous HCC was the strongest predictor of the development of a new HCC after DAA therapy. The more advanced liver disease and younger age were risk factors for HCC recurrence in the subgroup of patients with previous HCC,” Stefano Brillanti,
MD, assistant professor of medicine, University of Bologna, Italy, said during a press conference at the International Liver Congress 2016.

2.This large, retrospective cohort study included consecutive patients (n = 344) without HIV who had hepatitis C-related cirrhosis of Child Pugh A or B. Patients received various DAA combinations, none of which impacted sustained virologic response or HCC occurrence. Researchers followed them for 24 weeks after therapy concluded.

It is not clear to me with regard to:

1. above – having a previous HCC, by definition seems to be a good predictor of a recurrence of HCC, and I expect regardless of being cured of HepC?

2. above – does this just reflect what is said about HCC recurrence anyway? What was reported about quality of life by participants? Does not really says on the medpage website.

This paper seems to give a double meaning – HepC over the long term causes HCC, but at the same time, getting rid of it precipitates HCC?

The rest makes sense, but does not say how long post HCC the 29 per center’s were were and what treatment they got – transplant, resection, radiation, lipidol?

Have to admit this virus stuff is all very fascinating.

Yours

Jeff

Hi Dr Freeman,

saw your post in another thread about checking AFP’s monthly and having scans if any concerns – and thanks for this.

Did notice in the Journal of Hepatology (2016), doi: http://dx.doi.org/10.1016/j.jhep.2016.04.008 article, that Ribavirin ran a mention in the text as well as the following table of baseline details. The text bit relates to Meissner talking about Ribavirin having some affect on immune cancer control. I also note that in the baseline characteristics, use of Ribavirin was 82%, and the treatment duration was 76% in favour of 12 weeks vs 24.

Of course, seeing my profile and treatment it is easy to see why I would be thinking this way, but aside from this my mind goes back to an ex-partner warding me off the combination Interferon and Ribavirin so many years ago – likened to giving a dog arsenic to treat heart worm was what she said. The first time round with Interferon was not so bad.

I do remember the distinct change in feelings and energy in the first weeks of starting Sof/Dac and then EOT. My question is whether the presenter gave any indication that trying to beat the virus up too quick (12 weeks with Ribavirin) may be asking too much of the old liver?

Otherwise, off to have bloods done and nothing about Hep C surprises me any more.

Yours

Jeff

“Ribavirin is genotoxic and mutagenic and should be considered a potential carcinogen.” – http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/TherapeuticBiologicApplications/ucm094490.pdf

Thanks Price,

I remember from an earlier post of yours about carbs that I rethought my sugar intake, that is I decided I needed to be less of a porker and start losing weight again.

All things said, and my recent visit to the specialist reinforced this, there is more to keeping healthy and alive then using DAA’s, waiting for SVR, then expecting to have a long life. Another lesson this bastard virus has apparently taught me.

yours

Jeff

Yep,

some of us live between a rock and a hard place.

My understanding is that major (not all) risk factors of HCC recurrence were (still are) chronic HCV infection, fatty liver, and the amount of scaring. Hence the idea of being virus free.

I started to lose weight some 11 months before the DAA’s with a belief that the liver’s ‘fattiness’ may in some ways reflect the rest of the body’s ‘fatty’ state. Feeling shit with chronic HCV and the attendant lethargy of course does not help with trying to exercise; so black mark against HCV.

Can’t change the amount of scaring – but not having HCV may change the situation to where it isn’t getting worse.

Chronic HCV – well along came the DAA’s.

Of course now there is more than one rock and one hard place: DAA’s and possible HCC recurrence vs HCV leading to uncompensated cirrhosis and liver failure (and maybe HCC recurrence).

I don’t think there are right and wrong answers for all this, and one thing I know is that for different people there will be different answers, and for just one person like me there will be different answers as well.

Moral for those finding out they are HCV positive early in the piece, consider doing something early – though this may be proved to be wrong in the future.

Maybe titrating the DAA’s up and done starting and ending treatment??

Yours

Jeff

Hi James could you tell me what a AFP is ? I finished 24 weeks on the 9th april I havent lined up any tests yet. Can you supply any coupons for lab testing , as now we have to pay ? Also do you have any concerns about DAAs that there is now more being revealed that is a down side, or is it just inevitable that there is always a certain amount of damage done with meds, like chemo cure vs damage.Thank You Jill

Thankyou James should I do that asap or at 4weeks. I dont have a doctor monitoring me, Ive just relied on the forum and you….. which has been a pleasure. Havent felt the need to front up to royal melb as i can imagine they would have a pretty hefty waiting list by now. Can I just get these tests done at a local gp or should i go back to the mothership…royal melbourne. Thank you. Jill