Home Forums Main Forum Experts Corner DAAs as prophylaxis?

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  • #2310
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    There is a discussion about resistance here http://fixhepc.com/forum/experts-corner/164-resistance-and-treatment-failure-mechanisms.html

    Yes you could do that if the price was affordable.

    Yes you would expect to select for resistance to these agents, but this may not be a major issue for a variety of reasons.

    Personally I would suggest retreatment with a “longer and stronger” approach adding a third DAA and doubling the original treatment duration.

    Sofosbuvir resistance has already been seen http://www.medscape.com/viewarticle/818806_5


    YMMV

    #2311
    Avatar photoChester
    • Guardian Angel
    • ★★★★★
    @chester

    Hmm. I am yet to fully wrap my head around the resistance thing. Have read all the stuff on here and more. Hep c nurse said not to fuss about it much. If it comes back we’ll hit it again harder. Seems consistent with what you’ve said above. So resistance is an issue but not a big issue? Maybe this was all said in terms of the checklist she assessed my chances of SVR12 against (early responder, 1b, treatment naïve, minimal or no cirrhosis).

    I’m not worried. I’ve felt for the last week it’s all gone and I choose to believe it’s going to stay that way unless something happens to make me think otherwise. But in terms of breathing space for sicker people, it will be good if the current drugs have some use to keep more serious disease at bay until even better cures come along.

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