Does Intraocular pressure (IOP) decline after SVR?

This topic has 4 replies, 2 voices, and was last updated 6 years, 3 months ago by Dr James.

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11 September 2018 at 3:41 am #28536
beahavan
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- Guardian Angel
@beahavan
I have not been able to find any studies that show that the higher Intraocular pressure (IOP) associated with HCV declines after SVR.

Has this been anyone experience?

G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
11 September 2018 at 2:01 pm #28537
Dr James
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- Guardian Angel
@fixhepc
I can find the before, but not the after.

Patients with HCV are known to have higher Intra Occular Pressure (IOP) and other issues. IOP is measured with tonometry:

https://www.ncbi.nlm.nih.gov/pubmed/23470265

RESULTS:
HCV-infected patients presented an almost four times higher risk of lacrimal function involvement by tear break-up time [odds ratio (OR)=3.76; 95% confidence interval (CI) 1.75-8.04, P=0.001] and Schirmer’s test (OR=4.17; 95% CI 1.83-9.50, P=0.001) than the controls. The chances of palpebral biomicroscopic lesions (blepharitis) were also higher (OR=3.21; 95% CI 1.49-6.94, P=0.003). Mean tonometry was higher in HCV patients (right eye 14.4±2.3 vs. 12.2±1.5, P<0.001 and left eye 14.5±2.3 vs. 12.0±1.4, P<0.001).

YMMV
11 September 2018 at 5:35 pm #28541
beahavan
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- Guardian Angel
@beahavan
Yes unfortunately data on the effect of sustained virological response (SVR) on the risk of EHMs are limited. Nothing yet on IOP.

Thank you Dr James.

G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
15 September 2018 at 10:30 pm #28552
beahavan
- Topics: 5
- Replies: 81
- Total: 86
- Guardian Angel
@beahavan
IOP 2015 Right 16 Left 16
IOP 2018 Right 17 Left 16

So no decrease after treatment in my case.

G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
16 September 2018 at 3:21 am #28553
Dr James
- Topics: 264
- Replies: 1,968
- Total: 2,232
- Guardian Angel
@fixhepc
Thanks for the info beahavan.

With the normal range being around 11-21 that looks like being somethjng to keep an eye on rather than panic about

YMMV
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