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Welcome Tomas,
I probably wouldn’t wash the pills down with your SHFV smoothies just in case as there are probably a lot of sugars and acids in them. Sof/Led and also Sof/Dac can be taken with or without food depending on preference. If you have either with food I would suggest a light, reasonably bland meal to get them absorbed into your bloodstream as quickly as possible. I take my Sof/Dac with a couple of sips of water in the morning then go for a 45 min walk to the shop to pick up milk and paper. So when I sit down to breakfast the drugs are pretty much absorbed already. But some find they need to have them with a bit of food.
You may want to have a look in the Experts Corner area of the site where there is a bit of info about vegetarian diets etc if you are on one.However, I should warn that many of us find that once on treatment our careful, healthy diets go out the window! We can’t help ourselves and start eating things we haven’t had for years. I suspect part of this is that our bodies go into repair mode and we need extra protein and healthy fats to support that. Listen to your body and give it what it wants in moderation…..seems like a reasonable excuse to me?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Don’t know about the Led interactions as I just checked Dac which I need.
My understanding with Sof, Led and Dac is that you want to get them into the bloodstream and from there to the liver as quickly as possible so either on their own or with a light, low fat, easily digestible meal is best. This is why I take mine prebreakfast allowing time for them to be absorbed. I also take Ribavirin which should be taken with food and preferably with fat to better absorb it. So I have those after breakfast which is cereal and full fat milk (that’s new!) and again after the evening meal which I make sure has some fat either in the meal or as an extra. But that is just for Riba.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Oh dear – I haven’t got a clue what you mean Mike
Not sure ! but I read something about the drugs needing stomach acid to distribute through the body –
More details please mgalbrai
Bristol-Myers Squibb who invented Daclatasvir recommended against Grapefuit and Seville Oranges and marmalade containing either during the trials I participated in. The instruction was that Navels and Valencias would be fine. They made no mention of limes or lemons so presumably they are not an issue. I haven’t read Gilead’s instructions about meals but the rest of it relates to them being suitable for use with prescription antacid type products at up to certain levels for control of gastric reflux.
Otherwise avoid ‘potent’ inhibitors and inducers and if in doubt and you eat “a lot” of something like soy or miso or really anything else that you have concerns about it is probably best to at least reduce it particularly within a few hours of your medication, leave it out, or seek advice from above two companies or your specialist. Keep in mind that everyone who takes these medications reports finding their liver functions improving considerably and very quickly as well as the huge majority clearing the virus. So you may want to consider whether it is wise during treatment to use other additional methods of improving liver function which won’t clear the virus but could effect the medication.
And check the drug interaction charts which also contain the “big” known food and herb items like grapefruit and St Johns Wort.
Hope that helps.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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