HCC and DAAs - Treat the HCC first for better SVR rates

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11 March 2017 at 7:16 am #25551
Dr James
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- Guardian Angel
@fixhepc
This recent journal article observes that patient with HCC are 6 times more likely to fail HCV treatment than patients without liver cancer

On the good news side, it also observes that HCV treatment after curative therapies for HCC resulted in excellent SVR.

http://www.journal-of-hepatology.eu/article/S0168-8278(17)30053-3/fulltext

I would speculate that the accelerated uncontrolled cellular division present in HCC and the fact that cancer cells ignore the body’s apoptosis (literally f*** off and die) signals is why treatment is more effective if you kill of these cells first.

YMMV
11 March 2017 at 9:04 am #25553
Sven
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@sven
Doc – I love the anology: the cancer cells ignore the body’s apoptosis literally saying” f_ck off and die! Very well described,thank you.

Contracted HCV 1980’s
Geno Type 1a
F3 ( doc says once treated I’ll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count – 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 – Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
14 March 2017 at 12:47 am #25572
sabrecat
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@sabrecat
Sven wrote:

Doc – I love the anology: the cancer cells ignore the body’s apoptosis literally saying” f_ck off and die! Very well described,thank you.

Good analogy too for some big companies as well – thinking of my mobile phone service provider and no one else thanks.

Heading would have been less confronting if the word ‘active’ was in it!

J.
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