HCV New Drugs Blogspot

This topic has 175 replies, 27 voices, and was last updated 8 years ago by mgalbrai.

Viewing 15 posts - 91 through 105 (of 176 total)

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22 February 2016 at 6:10 pm #12452
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
From the weekend:

http://hepatitiscnewdrugs.blogspot.com/2016/02/watch-cost-of-curing-hepatitis-c-bbc.html

http://hepatitiscnewdrugs.blogspot.com/2016/02/second-state-sued-over-hepatitis-c.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
23 February 2016 at 8:29 pm #12529
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
New Screening and treatment criteria from WHO:

http://hepatitiscnewdrugs.blogspot.com/2016/02/new-recommendations-in-updated-who.html

Thousands recalled for hepatitis C test after NHS worker’s diagnosis:
http://hepatitiscnewdrugs.blogspot.com/2016/02/thousands-recalled-for-hepatitis-c-test.html

Bristol-Myers Squibb (NYSE:BMY) Presents Data on All-Oral Hepatitis C Regimen:
http://hepatitiscnewdrugs.blogspot.com/2016/02/bristol-myers-squibb-nysebmy-presents.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
24 February 2016 at 3:12 am #12540
sonix
- Topics: 7
- Replies: 158
- Total: 165
- Guardian Angel
@sonix
That last article is curious considering BMS withdrew application for approval of asuneprevir (in combination with daclatavir) in Oct 2014 Because –

In clinical trials, BMS’s combination, on the other hand, cured just 82 percent to 90 percent of those with genotype 1b after 24 weeks.

Source – https://www.hepmag.com/article/asunaprevir-end-26284-925493039

I wonder what changed, as they are reporting higher SVR rates in this trial?

M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia
24 February 2016 at 7:11 pm #12624
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Re Cirrhosis:
2/24/16

http://hepatitiscnewdrugs.blogspot.com/2016/02/alimentary-pharmacology-therapeutics.html

Re Zepatier:

http://hepatitiscnewdrugs.blogspot.com/2016/02/evidence-review-of-zepatier-vs-harvoni.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
25 February 2016 at 3:55 am #12638
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
sonix wrote:

That last article is curious considering BMS withdrew application for approval of asuneprevir (in combination with daclatavir) in Oct 2014 Because –

In clinical trials, BMS’s combination, on the other hand, cured just 82 percent to 90 percent of those with genotype 1b after 24 weeks.

Source – https://www.hepmag.com/article/asunaprevir-end-26284-925493039

I wonder what changed, as they are reporting higher SVR rates in this trial?

Looks like the 2014 report relates to earlier trials for approval for use in US so probably consisted mostly of western patient profile whereas these latest late stage trial results are for an all Chinese patient profile. This differing result is possibly to be expected as various racial groupings show differing responses to the old interferon treatments and also susceptibility to fibrosis/cirrhosis.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
26 February 2016 at 9:01 pm #12757
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Lots of good reading here:

Indian Patent Challenge:

http://hepatitiscnewdrugs.blogspot.com/2016/02/access-patent-challenge-hearing-on.html

ABBVIE RECEIVES CHMP POSITIVE OPINION FOR VIEKIRAX® (OMBITASVIR/PARITAPREVIR/RITONAVIR TABLETS) + EXVIERA® (DASABUVIR TABLETS) WITHOUT RIBAVIRIN FOR THE TREATMENT OF CHRONIC HEPATITIS C IN GENOTYPE 1B:

http://hepatitiscnewdrugs.blogspot.com/2016/02/abbvie-receives-chmp-positive-opinion.html

This version of the Guidance has been updated to reflect several important developments, including the recent approval of elbasvir/grazoprevir:

http://hepatitiscnewdrugs.blogspot.com/2016/02/elbasvirgrazoprevir-hcv-guidance.html

Why Americans pay so much more for drugs:

http://hepatitiscnewdrugs.blogspot.com/2016/02/why-america-pays-so-much-more-for-drugs.html

Quoted from the above article. Steve Miller, chief medical officer of Express Scripts wrote:

“The U.S. is 4.6 percent of the world’s population, we’re 32 percent of the world’s drug revenue, and we’re somewhere between 50 and 70 percent of world drug profitability,” Miller said. “The United States has been spending money to protect the world for decades. We’re now being asked to essentially fund all pharmaceutical drug development. … We cannot continue to carry this burden.”

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
29 February 2016 at 8:16 pm #12989
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Interesting…

http://hepatitiscnewdrugs.blogspot.com/2016/02/his-job-is-to-sell-1000-pill-for-10.html

RE; Australia:

http://hepatitiscnewdrugs.blogspot.com/2016/02/australia-hep-c-cures-now-as-cheap-as.html

Lack of awareness, affordability, etc.

http://hepatitiscnewdrugs.blogspot.com/2016/02/hepatitis-c-cure-now-affordable-but.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
4 March 2016 at 8:09 pm #13301
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Friday 3/4/2016

http://hepatitiscnewdrugs.blogspot.com/2016/03/watchdog-hepatitis-c-drugs-now-covered.html

http://hepatitiscnewdrugs.blogspot.com/2016/03/new-york-attorney-general-probes.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
7 March 2016 at 4:24 pm #13472
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
The”Buyers’ Club Era” article, among others:

http://hepatitiscnewdrugs.blogspot.com/2016/03/march-heaptitis-newsletters-with-news.html?m=1

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
8 March 2016 at 10:27 pm #13538
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Recommendations from John W. Ward, MD, director of the Division of Viral Hepatitis at the Centers for Disease Control and Prevention (CDC).:

http://hepatitiscnewdrugs.blogspot.com/2016/03/cost-keeps-hcv-care-out-of-reach.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
10 March 2016 at 10:19 pm #13634
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
From the CDC:
Annual Report to the Nation: Cancer death rates continue to decline

Increase in liver cancer deaths cause for concern

http://hepatitiscnewdrugs.blogspot.com/2016/03/cancer-death-rates-decline-but-increase.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
14 March 2016 at 5:08 am #13784
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Merck vs Gilead:
http://hepatitiscnewdrugs.blogspot.com/2016/03/a-tale-of-two-new-hepatitis-c-drugs.html?m=1

Insurers rail against exorbitant drug costs:
http://hepatitiscnewdrugs.blogspot.com/2016/03/insurers-academics-protest-high-cost.html?m=1

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
17 March 2016 at 6:53 pm #14035
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Some good reading here in “HCV Next”

http://hepatitiscnewdrugs.blogspot.com/2016/03/hcv-next-narrowing-gap-impact-of.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
18 March 2016 at 7:33 pm #14129
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
3/18/16

http://hepatitiscnewdrugs.blogspot.com/2016/03/mar-2016-update-upcoming-and-recruiting.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 March 2016 at 6:39 pm #14340
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Why U.S. prices will stay high:

http://hepatitiscnewdrugs.blogspot.com/2016/03/no-clear-path-to-government-lowered.html?m=1

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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