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  • 5 April 2016 at 4:25 am #14907
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    Now I know why I’m not a doctor….

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    5 April 2016 at 8:29 am #14911
    Jonathan
    • Topics: 1
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    • Acolyte
    • ★★
    @jonathan

    But if RBV is in the mix it would be significantly longer than six months! James, over to you on that one.

    5 April 2016 at 9:57 am #14914
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    The half life of Riba is 12 days so we would need 6 times as long as the Ledipasvir – about 36 months

    The rule of thumb would be 3 months per day of half life.

    YMMV

    8 April 2016 at 9:38 am #15066
    Avatar photoCC2B
    • Guardian Angel
    • ★★★★★
    @cc2b

    So don’t want to go off subject too much,but as far as some of the supplements or foods I stopped taking during sof/dac tx, can I start taking these again at EOT? Or is it better to wait a while?

    GT2b diagnosed 10/2015
    since: unknown
    11/20/15 VL= 214,070
    12/4/15 ALT=18 AST= 24
    1/16/16 started sof/dac
    2/13/16 @4wks VL=UND ALT=13 AST=22
    3/12/16 @8wks VL=UND ALT=10 AST=18
    4/9/16 EOT VL=UND ALT=11 AST=19
    9/23/16 SVR24 ALT=11 AST=22

    8 April 2016 at 11:45 pm #15095
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    According to this article, we each have about 32.7 Trillion cells in our bodies.

    http://www.smithsonianmag.com/smart-news/there-are-372-trillion-cells-in-your-body-4941473/?no-ist

    Now, 32.7 trillion = 32.7 * 10^12. So if you are thinking about how much of an unwanted drug molecule you might want to have in your body, wouldn’t it be reasonable to say you’re pretty safe if you get down to less than about one molecule per cell?

    Or in terms of moles, your pretty clean once you get down to about 6.023*10^23 / 3.27*10^13 = 2*10^-10 = 20 nano-moles?

    Me, I’m pretty sure I’ve got nanomoles of all kinds of crap in my body, but it probably isn’t doing any harm (and I don’t believe in homeopathy).

    So wouldn’t this be a “safe enough” point at which to break out the champagne and have an early night?

    [… Just a thought, since getting pregnant is physically impossible for me as I am only a cartoon character… ;) ]

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

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