Hi Mark

While there’s much more data associated with ledipasvir in combo with sofosbruvir, daclatsavir has been trialled with a cohort of hard to treats, tx experienced and co-infected HIV (Ally 2). I rate both of them and have decided on the dalatasvir and will assess a 4 weeks. i haven’t done this based on cost but more to do with the good data associated with no ribavirin. Flip a coin maybe? Em

After looking at the data I’m going with sof/dac. And not really for financial reasons, I had thought of hitting it hard with sof/dac/led/rib.
I’ll know in another week or so what my liver looks like and I’ll skip the rib if it looks like I don’t really need it. And I’ve got a bit of an agenda now.

So Mr. Time, here’s what you can do to help humanity …. and I’m serious.

In the US dac is only approved for type 3. Gilead has been unwilling to participate in trials with BMS … not in their financial interest.
Essentially BMS is limited here to a small subset of HCV patients. As I understand, in Europe sof/dac is approved across all types, but just how many countries are following the US lead on this? I don’t know, but my understanding is that most of Gileads income so far has been in the US anyway. BMS seems content to not price compete and take their type 3 profits.

Let’s push them.

If the results are as good as anticipated, and if enough of us are tracked by our good doctor here, and if he publishes his results, that uncertainty statistic drops …… BMS just might decide to price compete. The Indian generic makers might decide to make sof/dac tabs hitting Gileads royalties. AbbVie might decide they have to price compete or miss out entirely.

What do you say?

Just noticed that I never replied …. yes, I’m 1a. I put more details in my trip thread.

At this point I’m going to go with whatever I can get my hands on …. sourcing this stuff is taking much longer than I had expected or scheduled for.

Problem is, I’m on my trip and the clock is ticking.

Dr Freeman can’t ship to me out of country, and Australia is a more expensive place than my trip was budgeted for.
If I’m going to have to go to China or Bangladesh or India to get the drugs myself, I need to know soon.

Also, my employer won’t let me stay on leave forever …. I gotta do this now.

where are you located now?

You are in good hands.

Doctor freeman is very knowledgeable! Better than some gastro doctors i have seen

Just a curious question here:

If mesochem ledipasvir is 1100 usd, and twinvir is sof + led for 1100 usd, is it possible that there are different grades of led api available in the market? How they manage to keep the price low? ( assuming the sof + led they use work when the test results are out )