Please note that although the standard dose of Ribavirin is 1000 mg daily for patients < 75 kg and 1200 mg daily for patients > 75 kg given as 2 divided doses this must be reduced if your kidney function is lower than usual.
Ribavirin is given in 2 divided doses – one in the morning, one at night. Because it comes in 200 mg capsules it looks like this:
< 75 kg - take 2 x 200 mg in the morning, 3 x 200 mg in the evening (or 3 in the morning and 2 at night)
> 75 kg – take 3 x 200 mg in the morning, 3 x 200 mg in the evening (or 3 twice a day)
Kidney function is measured by Creatinine and eGFR
With good kidney function your Creatinine is low and your eGFR is high (> 60)
With poor kidney function your Creatinine is high and your eGFR is low (<60)
eGFR is estimated Glomerular Filtration Rate
A Glomerulus is on of the millions of little blood filters in your kidneys.
The required Ribavirin dose reduction in renal failure is discussed in this article:
http://www.drugs.com/pro/ribavirin.html
.
