So what are the REDEMPTION eTrials?

This topic has 38 replies, 19 voices, and was last updated 8 years, 2 months ago by Gaj.

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18 October 2015 at 3:41 pm #2451
Sirchinenge
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- Guardian Angel
@sirchinenge
The reason The buyers club was offering an API from China as opposed to say
Twinvir is due to the fact they could not avail of Twinvir at that time.

An API is the active ingredients in the drug.

Twinvir or any other Generic is made from an API sourced from various countries
including China you are taking the equivalent of these drugs.

The only difference in how you purchased, you bought the drugs in raw form from
China. The buyers club takes your API tests it and then encapsulates them.

Encapsulating equals putting the API(Powder) into a capsule you can swallow.

You have nothing to worry about.

Note; The questions you both have are appreciated, this thread is going off Topic a such if you have questions about APIS
and the difference between various drugs please, put them in a separate thread.

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
18 October 2015 at 3:49 pm #2452
Dr James
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- Guardian Angel
@fixhepc
Don’t panic!

An API is what is known as the “Active Pharmaceutical Ingredient” ie Sofosbuvir or Ledipasvir.

If you take Gilead as an example the APIs for Harvoni are made in Jordan.

This chemical powder is then shipped to Ireland where the two parts are mixed with glue, lactose (milk sugar), fibre, disintegrant, sand, wax and pressed into tablets.

The extra bits are called excipients and can be used to control rate of release but in the case of Harvoni it’s a fast release instant dissolution.

Harvoni Excipients:
- Copovidone (glue)
- Lactose monohydrate (sugar)
- Microcrystalline cellulose (fibre)
- Croscarmellose sodium (disintegrant)
- Colloidal anhydrous silica (sand)
- Magnesium stearate (wax)
What you have is the APIs mixed with Microcrystaline cellulose in a capsule that, like Harvoni releases the API rapidly. The other parts of the tablet are only used to make the table stick together, and then dissolve in your stomach. It’s cheaper to make a tablet than a capsule which is why they are commonly used.

There are now hundreds of people now have taken Sofosbuvir/Ledipasvir in this form and are at viral load zero.

The APIs in both Twinvir and your medication came from China (different large scale factories). They are chemically identical the the APIs in Harvoni and you can read the testing reports about that here: Testing Provisions Patient Safety.

YMMV
19 October 2015 at 10:10 pm #2497
Vororo
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- Guardian Angel
@vororo
Hello Dr Freeman, Hello world!

Please can you explain the REDEMPTION trials a bit more? Is this essentially something that you are organising with The Club? Does it mean that you will be asking the members to send you their treatment results?

If so, I would like to say that this is really another GREAT INITIATIVE from Down Under, and it must be one of the best ways possible to show ordinary GPs that it is OK to prescribe DAAs… Me personally, I will be happy to participate (my own wire transfer to The Club went through a few days ago, I think….

Lets all help to Bust the Scare-Mongering Myths About “Generics” and Buying From “Abroad”!!

Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).
20 October 2015 at 1:22 am #2510
LondonGirl
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- Guardian Angel
@londongirl
Any idea when more info will be forthcoming Sirchinenge? Thx LG.

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
20 October 2015 at 1:37 am #2513
Sirchinenge
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- Guardian Angel
@sirchinenge
The trials are simply to gather evidence that Generics do work they also provide
an opportunity to offer access to treatment to as many people as possible.

I don’t think the plan is to add in anyone who has bought over the last few weeks.

Two reasons stand to mind; 1; The price point for the buyer club is not the same
as the Redemption Trials.
2; The Buyers club was only offering two drug options from one
source in China. The Trials are offering more drug choices from a variety of suppliers in Bangladesh.

What information are you looking for London Girl?

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
20 October 2015 at 2:12 am #2516
LondonGirl
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- Guardian Angel
@londongirl
I don’t know, I think there was mention of more details ‘on Monday’? The time difference can be confusing too!

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
20 October 2015 at 2:43 am #2517
Sirchinenge
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- Guardian Angel
@sirchinenge
http://fixhepc.com/forum/redemption/210-redemption-medication-supplier-incepta-pharma.html

http://fixhepc.com/forum/redemption/209-redemption-2-and-3-timelines.html

I think you’re referring to the threads linked above which he added at the weekend he
obviously got around to it before today.

I don’t think there’s much to add at this juncture.

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
20 October 2015 at 3:34 am #2523
2b
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- Total: 349
- Guardian Angel
@2b
My question relates to the Corevigen single pill combo of daclatasvir and sofosbuvir that is to be used in the Redemption 2 trial, my question is does anyone know when that corevigen is going to be available?

GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””
20 October 2015 at 3:57 am #2525
2b
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- Guardian Angel
@2b
Ok, just got that answered, looks like mid november target date, but only after thorough testing is complete and tests good.

GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””
21 October 2015 at 10:38 pm #2605
Debs
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- Guardian Angel
@debs
Hi Dr Freeman, here’s hoping that consultants in the NHS will acknowledge this worldwide trial and will monitor treatment if a person is on it.
Also is there a limit to how many can go on the sof/led trial? Could I put my name down now?
Thanks, Deb
14 November 2015 at 4:03 pm #3945
Nonna
- Topics: 0
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- Total: 9
- Novice
@nonna
I think you would be just the man for the job Emilio. The trials sound like a great idea.
22 January 2016 at 12:56 pm #10084
LondonGirl
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- Total: 1,364
- Guardian Angel
@londongirl
This should help maybe Debs? :

https://www.clinicaltrials.gov/ct2/show/NCT02657694?term=redemption&rank=1

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
17 February 2016 at 1:45 am #12027
Debs
- Topics: 6
- Replies: 243
- Total: 249
- Guardian Angel
@debs
Hi! Have just updated my data for the trials – It is so user friendly! And I am so happy because I could write UND as my 4 week results!
Good to see people getting great results on these trials,
Million thankyous Dr F
And of course the wonderful Monkmed!
17 February 2016 at 1:49 am #12028
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
17 February 2016 at 2:54 am #12038
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
Great news Debs!

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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