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I had always a problem with the cholesterol, since my 20s . High cholesterol.
hmy:
This means that it is harder to treat hep C because I ‘offer’ more transportation for viruses?
Thanks!
Hi Phoenix,
I have not been a big believer in supplements figuring that if you are fit and well and eat a balanced, varied diet you should get all you need from that without requiring extras. However, recent reading such as the doc’s musings above along with further research has me pondering the facts that I am fast approaching the big six-ohh and have probably had chronic hep c for 2/3 of that period! Apparently neither are ideal for helping to extract all the nutrients you need from even the best diet. So I’m taking myself off to my GP for some diagnostics to see where I am lacking and will be giving serious consideration to supplements such as B-complex (+ extra B12?), Betaine, SAMe and now ALA.
For your question, the post above and the references quoted in it don’t seem to give any concern of a likely interaction between these items and Dac or Sof. Hope this helps.and now vitamin D as well.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thank you Dr. James,
I’ll check for B12. I already know that I have vit D deficit.
My LDL is 149 mg/dL – borderline 130-160 mg/dL
I’ll check with my doctor for statin.But if I understand correctly, statin & B12 supplement & vit D supplement & antioxidant only end of treatment, after 12 weeks of Twinvir.
Am I right?
Thanks!
Hi LondonGirl,
I know that B12 and vit D supplements were studied for IFN / RIBA.
But where is a deficiency probable is worth taking supplements/vitamins.My question comes from mentioning aid for SVR and RVR.
So, taking B12 & vit D& statin & antioxidant AFTER and/ or DURING treatment with DAAs.
Thanks again!
Thank you LondonGirl and Dan,
I avoid all supplements, vitamins and other medication because I am afraid of unknown interactions with Twinvir.
I don’t know, maybe is wise after finishing the treatment to consider the all four:
B12 and vit D if there is a deficiency.
Antioxidant] like ALA and statin for ”bad” LDL cholesterol.
Hi All,
I think there are a couple of points here:
1.) Most of the data currently available is for old Interferon treatments which is understandable due to short period that DAAs have been in use. But what we do know from that old data is that people with hep c tend to be deficient in B12 and D vitamins, even more so in those in the over 50s age group when our bodies become less efficient at extracting/manufacturing them from our normal diet. But we also need to remember that interferon is not some drug from outer space that our bodies have never seen before. We naturally produce our own similar interferon chemicals to boost our immune systems, see link.
https://en.m.wikipedia.org/wiki/Interferon
What we refer to as interferon treatment is the addition of extra artificial interferon to try and compensate for/trigger extra immune response to fight the virus. So boosting B12 and D should still assist our natural interferon to fight the virus. The ALA, Betaine, SAMe, etc and the rest of B group complex are part of the process of converting/using B12. So ensuring that we have sufficient of each of these should assist our bodies in absorbing enough B12 to support both the fight and healing process. In other words, while the DAAs kill the virus, our bodies need to efficiently dispose of those dead virus and then heal the damage they caused.
2.) RVR is at the start of treatment and SVR is the hoped for result after treatment. You could also include another Viral Response group in there and maybe call it MVR (Maintained Viral Response or continuing UNDetected readings after RVR and before SVR) So the whole process of treatment and then waiting for confirmation at SVR12/24 needs to be supported by maintaining good B12 and vit D levels throughout the whole period.
In other words maintaining B12 and D levels, and the other things that support that process, at upper normal range throughout treatment should be beneficial when using DAAs just by not starving our bodies of the required nutrients even though it hasn’t been proved in trial yet.
The above is my understanding in simplified terms as best I can describe so if any scientists/medicos out there spot any basic errors please feel free to correct my admittedly laymans understanding.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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