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  • 25 October 2016 at 12:40 pm #24016
    Avatar photohonker
    • Topics: 6
    • Replies: 79
    • Total: 85
    • Guardian Angel
    • ★★★★★
    @honker

    I have picked up a toe nail fungus and oral medication has been recommended. I am now undetected and liver function is normal, Is it alright to take medications that are hard on the liver. What tests should I apply to making this decision?

    Diagnosed in 2000, Genotype 1(b), no previous treatment,
    Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
    Fibroscan F0
    Starting Redemption Sof/Led on February 2, 2016
    Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

    Feb. 29
    Week 5 of tx
    ALT 23
    Undetected

    May 26
    4 EOT
    ALT 25
    AST 28

    Didn’t test for viral load. Will test is July at 12 weeks EOT

    August 1
    Liver enzymes in normal range
    HCV UNDETECTED

    26 October 2016 at 12:52 am #24021
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    The oral antifungals are all a bit toxic. That is because fungal cells are very like human cells and therefore very hard to target without some collateral damage.

    That said, these drugs are generally safe and severe liver toxicity is very rare.

    One option would be to try intensive topical treatment for a good 3 months plus and use oral treatment only if that fails

    YMMV

    26 October 2016 at 2:31 am #24022
    Avatar photohonker
    • Topics: 6
    • Replies: 79
    • Total: 85
    • Guardian Angel
    • ★★★★★
    @honker

    Thanks James. I will try that.

    Diagnosed in 2000, Genotype 1(b), no previous treatment,
    Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
    Fibroscan F0
    Starting Redemption Sof/Led on February 2, 2016
    Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

    Feb. 29
    Week 5 of tx
    ALT 23
    Undetected

    May 26
    4 EOT
    ALT 25
    AST 28

    Didn’t test for viral load. Will test is July at 12 weeks EOT

    August 1
    Liver enzymes in normal range
    HCV UNDETECTED

    26 October 2016 at 4:30 am #24024
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    I have just started using a generic version of loceryl and I’m still alive. Can’t comment on its efficacy yet, apparently you have to apply it once a week for 6 to 12 months :ohmy:

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    26 October 2016 at 5:57 am #24025
    Avatar photohonker
    • Topics: 6
    • Replies: 79
    • Total: 85
    • Guardian Angel
    • ★★★★★
    @honker

    Thanks. Are you taking the oral med? I don’t think the topical poses much problem for the liver, but have been warned that oral medication may. I am going to try a tea tree application to see if that can help before hitting the heavy artillery. I’ll keep you posted and thanks for the response.

    Diagnosed in 2000, Genotype 1(b), no previous treatment,
    Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
    Fibroscan F0
    Starting Redemption Sof/Led on February 2, 2016
    Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

    Feb. 29
    Week 5 of tx
    ALT 23
    Undetected

    May 26
    4 EOT
    ALT 25
    AST 28

    Didn’t test for viral load. Will test is July at 12 weeks EOT

    August 1
    Liver enzymes in normal range
    HCV UNDETECTED

    26 October 2016 at 5:57 am #24026
    Avatar photohonker
    • Topics: 6
    • Replies: 79
    • Total: 85
    • Guardian Angel
    • ★★★★★
    @honker

    Thanks. Are you taking the oral med? I don’t think the topical poses much problem for the liver, but have been warned that oral medication may. I am going to try a tea tree application to see if that can help before hitting the heavy artillery. I’ll keep you posted and thanks for the response.

    Diagnosed in 2000, Genotype 1(b), no previous treatment,
    Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
    Fibroscan F0
    Starting Redemption Sof/Led on February 2, 2016
    Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

    Feb. 29
    Week 5 of tx
    ALT 23
    Undetected

    May 26
    4 EOT
    ALT 25
    AST 28

    Didn’t test for viral load. Will test is July at 12 weeks EOT

    August 1
    Liver enzymes in normal range
    HCV UNDETECTED

    26 October 2016 at 6:34 am #24027
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Loceryl is a topical agent used once a week.

    The application time depends on speed of nail growth.

    What you expect to see is new health nail growing outwards. Once all the infected nail is gone (ie trimmed off) treat for a bit longer to be sure, but you can see it progressively growing out.

    YMMV

    26 October 2016 at 4:50 pm #24028
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    I’ve tried tea tree and various similar things including Chinese herbal medicine but none of then worked for me. :(

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    27 October 2016 at 4:01 am #24032
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I’m not anti herbal but things like Loceryl are designed for, and fit for, purpose.

    YMMV

    28 October 2016 at 4:28 am #24037
    cdmazoff
    • Topics: 2
    • Replies: 17
    • Total: 19
    • Acolyte
    • ★★
    @cdmazoff

    Tea tree oil has had great results with treating toe nail fungus. There are clinical trials on this. I too have toenail fungus and now that I’m cured of HCV I’m using tea tree oil.. Dab it on twice a day.. I’ve really reduced the area affected

    28 October 2016 at 5:42 am #24038
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    I’m glad it’s working for you. I never had any luck with it but now I’m inspired to give it another go. Maybe now that my immune system is no longer overworked I’ll have more success.

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    29 October 2016 at 10:34 pm #24059
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    I’ve tried the shot, but this stuff works.
    It takes as long as it takes for the nails to grow, but, with once daily tx, you will never have those nice, thick, yellow nails again.
    Once clear, keep treating before bedtime. The shit is insidious but it can’t stand the Nonyx.
    The Kera makes them look nice until its gone.
    m
    IMG_2642.JPG

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    9 November 2016 at 7:43 pm #24235
    Zsuzsi-Snarey-facebook
    • Topics: 0
    • Replies: 1
    • Total: 1
    • Novice
    • ★
    @zsuzsi-snarey-facebook

    I am a chiropodistodiatrist of over 15 years of experience and I have not found Loceryl (amorolfine) to work except for the mildest of surface infections. I have known people to persevere for years without success.
    Terbinafine on the other hand invariable works although it might take 8-12 month, in rare cases 18 months. If your GP worries about liver damage he can order liver function tests.

    10 November 2016 at 5:02 am #24240
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Hey Zsuzsi, Lovely to see you here and giving advise. Hope you are well. LG
    (Sent you a PM) x

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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