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  • 7 May 2016 at 3:58 am #16770
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Hi Serg,

    Are there any links available to the report? I haven’t seen any studies published previously about effects of IL28b gene on DAA response.

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    7 May 2016 at 10:13 am #16778
    Serg
    • Topics: 4
    • Replies: 66
    • Total: 70
    • Recovery Champion
    • ★★★★
    @serg

    Hi, Gaj! Yes – page 708 in http://ilc-congress.eu/wp-content/uploads/2016/abstracts/20160416_sat/sat_ilc2016_no_embargo_lr.pdf , “GENDER AND IFNL4 RS12979860 GENOTYPE PREDICT RESPONSE TO LEDIPASVIR/SOFOSBUVIR”

    Probably infected in 1977
    2005 – diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
    2005-2006 – PegIFN/rib 48 weeks treatment, relapse
    2016 – compensated F4, MELD 8-9, ALT 100-160
    2018 – compensated F4, MELD 8, ALT 91

    7 May 2016 at 11:11 am #16779
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Thanks Serg,

    I also see on the same page a report about vitamin D supplementation reducing the presence of NS5A RAVs.

    SAT281
    LOW SERUM 25(OH) D3 LEVEL AFFECTS THE EXISTENCE OF DRUG-RESISTANT MUTATIONS AT THE NS5A REGION IN PATIENTS WITH CHRONIC HEPATITIS C 1B

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    8 May 2016 at 11:11 am #16823
    Serg
    • Topics: 4
    • Replies: 66
    • Total: 70
    • Recovery Champion
    • ★★★★
    @serg

    Thanks, yes, it is interesting…

    Probably infected in 1977
    2005 – diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
    2005-2006 – PegIFN/rib 48 weeks treatment, relapse
    2016 – compensated F4, MELD 8-9, ALT 100-160
    2018 – compensated F4, MELD 8, ALT 91

    8 May 2016 at 12:27 pm #16826
    Avatar photoPrice
    • Guardian Angel
    • ★★★★★
    @price

    But the story has a happy ending.

    P

    8 May 2016 at 1:57 pm #16828
    Avatar photoPrice
    • Guardian Angel
    • ★★★★★
    @price

    It was hell. First we had Rebetron with 3 weekly injections and only 800mg of Ribavirin for everybody. Viral loads that measured down to 600 and we checked viral loads at 24 and 48 weeks.

    Many GPs knew nothing about HCV or treating and lowered doses as soon as the white cells (not neutrophils) decreased. When people got anemic they checked the stool for bleeding and prescribed iron. When patients had severe side effects, they gave them 2 week “vacations” off meds. There were lots of serious side effects….hearing loss, retinal bleed, new onset diabetes, arthritis, depression and more.

    When PegIntron came along, their supply was low so patients had to be put on a waiting list. The injection came in powder form and we had to teach people how to mix it and draw up the correct dose.

    And the forums were a total nightmare . Lots of trolls and you could get banned for just about anything. Doctors told people to stay out of forums.
    We’ve come a long way.

    PP

    8 May 2016 at 2:10 pm #16830
    Avatar photoPrice
    • Guardian Angel
    • ★★★★★
    @price

    One of the docs at Research Gate said, “results will vary country to country and population to population. for example IL28 was found to be associated with IFN treatment response in HCV but here in Pakistan we have found no association.”. On the other hand, Fiji and New Guinea found that all patients positive for HCV had no viral load and all had protective haplotypes.

    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066749

    P

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