Which DAA regimen should include ribavirin?

This topic has 3 replies, 3 voices, and was last updated 9 years, 1 month ago by Dr James.

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4 October 2015 at 4:53 am #1762
Dr James
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@fixhepc
A patient posted this in another thread. It is a key thing to understand.

[video]https://www.youtube.com/watch?v=vCcpES8O6P0[/video]

YMMV
4 October 2015 at 4:57 am #1763
tweakmax
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@tweakmax
Doc freeman may be right abt sof + dac + sime combo

Janssen doing a trial on it
4 October 2015 at 9:32 am #1767
miko3
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@miko3
Dr James.Some suggested regimes call for a 7 day lead in with sof alone,before adding any extra DAA’s.This is not mentioned in the excellent video clip.Do you have an opinion on this or is it irrelevant?

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
4 October 2015 at 10:55 am #1768
Dr James
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@fixhepc
Hello Miko, yes I have an opinion. I think it’s a bad idea based on the mechanisms of resistance. If you think of killing Hep C as being like killing all the enemy soldiers in an area you don’t start half hearted, you go in with overwhelming force and kill everyone before (selected resistance) provides an opportunity for the enemy to regroup.

On the more evidence based front patients taking Harvoni (before it even had that name) in the ion-1 trial took the Sof+Led combination from day 1. Why vary from that proven approach?

YMMV
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