Dr freeman,

Regards my getting testing done in the UK, I do not have proven reference samples of the brand name drugs for comparison purposes. Would you expect your colleague to supply these?

DT

Dr Freeman,

Many thanks for this information. I am still trying to absorb the implications for me of the comprehensive testing that you have done on the Mesochem drugs. This new information, that the Mesochem drugs are indeed identical to the brand name, puts them on a par with the Indian licensed generics.

The hepC landscape is moving very fast. Sometimes it seems to change daily. I want to consider my options till around Xmas this year and start tx early in the New Year. I don’t wish to trouble you with extra work when you obviously have your hands full already, but I may very well wish to take you up on the offer of finding a colleague in the UK who could replicate the testing for me that you are doing.

Best wishes,
dointime

Best wishes,
dointime

Wow, that sounds really really good and a process that a patient could trust. I wish I could get my meds tested like that. Do you have any suggestions on how I could do that? Maybe I should just come to Tasmania. I’m half joking, but why not. I am already looking at travelling to Delhi or Beijing to get meds based on trusting the supplier and minimizing the supply line. Your testing is better still.

Are you using the Daclatasvir then for some people? I am interested to know how it is decided to use Daclatasvir rather than Ledipasvir. I see that there could be financial reasons (led costs at least 4 x dac) but are there clinical reasons why it is more appropriate in some situations?

I am also just curious – what genotype do you see most of in your area, if one type is prevalent?

Thanks,
dointime

Em –
UK government policy! I can’t speak for them but I can say that my doc practically made the sign of the cross when I mentioned the Indian generics, so I never got the nerve to say anthing about the Chinese APIs.

Dr Freeman –
I very much appreciate the detailed information that you have provided so far. I wish we had somebody here in UK doing the pioneering work that you are doing. Unless I am willing to simply sit and wait till I develop advanced liver disease, it is DIY for me here at the moment I’m afraid. So all the information that you can supply is invaluable in helping me make informed choices as to my risk of doing nothing versus the risk of doing something, for example using the Mesochem APIs or the Indian generics – always supposing that I can obtain either.
On the question of an open data collection poll I am not sure, for the reasons that you have stated.

Best wishes,
dointime

Hi Dr Freeman,

Many thanks for this answer.
So if I’m understanding you correctly, >99% Pure means >99% free of impurities.
It does NOT say anything about the medication being an accurate copy of the brand name drug, therefore it does NOT imply that similar results to the brand name drug can be expected.

So which is the test that shows that the Mesochem drug is an accurate copy of the brand name drug? I take it that that would be the NMR Comparison test. I would like to get an NMR comparison test on any drugs that I receive. Do you know how / where could I get this done?

Best wishes,
dointime