Hi barry666,
Seroquel is “industrial strength” so it’s definitely something you don’t just stop cold turkey.
Talking to your GP is a great idea. You will be taking Maviret + Sofosbuvir so we want your medications to play well with this combination.
If you put in Maviret (Glecaprevir/Pibrentasvir) + Sofosbuvir here and then Quetiapine
You will see the interaction – this basically says reduce the Quetiapine dose a bit, however there are alternatives:
https://www.hep-druginteractions.org/view_all_interactions/320174?co_drug_id=1455
Risperidone and Olanzapine are similar so you could swap to them but a simple dose reduction (when you start treatment) would probably be all that is required.
Summary:
Coadministration with quetiapine does not preclude the use of glecaprevir/pibrentasvir. Quetiapine is metabolised by CYP3A4 and in vitro is a substrate of P-gp. Concentrations of quetiapine may increase as glecaprevir/pibrentasvir is a weak inhibitor of CYP3A4 and P-gp (27% increase in AUC with probe 3A4 substrate midazolam; 45% increase in AUC of tacrolimus).Whilst unlikely to be clinically significant in most patients (a recent study having looked at the efficacy and safety of G/P in patients with chronic HCV and psychiatric disorders) , caution is advised when using higher doses of quetiapine (e.g. over 400mg/day), or with liver impairment, the elderly, patients with cardiac conduction abnormalities or other drugs known to prolong QT interval. Concomitant administration of cytochrome P450 3A4 inhibitors, such as HIV-protease inhibitors, azole-antifungal agents, erythromycin, clarithromycin and nefazodone, is contraindicated in the European label for quetiapine.
