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Viewing 15 posts - 1,711 through 1,725 (of 1,968 total)
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  • in reply to: Viral Load – Quantitative vs Qualitative #5281
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    The list price is $180-200 AUD but if you ask nicely I know Sonic (blue disc with red double helix) labs – the have many different brands – have been doing them for around $135. Ask for a quote is my tip!


    YMMV

    in reply to: Taking longer that expected #5271
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Sue,

    Make sure you have an AFP (checking for HCC) and/or an U/S

    Also remember that just because you have HCV you are not immune from other things, so in the event you have ongoing symptoms, we should dig deeper.

    Fatigue is a noted side effect of the medications, and some people don’t start to feel significantly better until a month into treatment.


    YMMV

    in reply to: worser and worser…should be a scandal #5269
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Kevin,

    Gilead bought Pharmasset on Nov 21 2011, then we have the various Phase 3 trials over 2012/13

    In my defence I did say UNDER 3 years, which is also wrong because it has been just over 4 years since the purchase and just over 2 years since Gilead got a licence to start printing money.

    How about we call it making a motza a minute?

    With nearly $30 billion in over 2 years it’s around $40 million a day so Pharmasset’s original $324 million R&D investment is being returned every 8 days.


    YMMV

    in reply to: worser and worser…should be a scandal #5262
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Patents are important to protect IP, the problem is they produce a monopoly power that is open to abuse.

    The world at large needs a mechanism to bring the pendulum back towards the centre.

    To swing it all the way from monopoly to “ignore the patent” would be just as problematic as leaving it where it is.

    The bottom line is that Sofosbuvir cost $375 million to develop. That’s a lot of cash, and a lot of risk. The Pharmasset investors got a great 30 x return, Gilead have got a great (almost risk free) 3 x return in under 3 years. Everyone who took a risk has been paid back in spades and now it’s time to provision the world with this cure, and for the next Pharmasset to develop the next great antibiotic.

    Big Pharma has gotten fat and lazy – consider statins – we have 9 different ones – that’s one great new idea and 8 “me too” clones. Almost all the me to clone money could have been better spent on new ideas.

    We need more innovation and less low risk sequels.

    To make that happen we need to incentivise it, and the best way to do that is to adopt drug purchase/subsidy policies that look like “we need 2 good solutions to this problem” – who’s offering the best prices? New Zealand do exactly that and enjoy medication prices 1/8 what Australia pays and very similar health outcomes.

    Australia is idiotic in this regard – we do not need all the statins to be subsidised and doing so removes price competition. It’s about time we got a clue and put our tax dollars to better use incentivising new blockbusters, not yet another sequel.


    YMMV

    in reply to: Drinking alcohol #5239
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I can relate…I too drank my 3-4 Barcardi’s EVERY night and when younger drank regularly and quite heavily sometimes. My Fibroscan and Ultrasound only showed a fatty liver and the last LFT was good……I certainly dodged a bullet I think being diagnosed (quite by chance) and am now on treatment…..have my four week blood test next week and will hopefully find out on 21/12 the results…very nervous but hopefully will have a good outcome. I now drink Holsten’s non-alcoholic beer…..quite a nice drop once you get used to it. :)


    YMMV

    in reply to: Within 24 hours we have enough to treat 3 people! #5056
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Thank you G…..I have chosen which family and friends to tell regarding the virus. I have spoken to my husband and children and they are very supportive of me “getting the word out” through my FB. If I can even alert a handful of people to the Buyers Club it will be worth it and of course social media is a good way to get the word out there. :)


    YMMV

    in reply to: Within 24 hours we have enough to treat 3 people! #5031
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Well that bought a tear to my eye….so sad for him, I hope it all turns out okay. I will be making a donation (around $100 as I can’t afford much more before Xmas but certainly will continue to donate next year). My employer matches any donation I make to charity so that will be $200 before Xmas. May go a small way to helping someone who so badly needs the medication.

    I will definitely be Facebooking my experience (if that is okay to do so). There are many whom I know (family & friends) who do not know I have the virus but I am more than happy to put my experience on my FB and if it helps even one person who has not heard of the Buyers Club I will be happy. If it isn’t appropriate to “advertise” the Buyers Club on my person FB please let me know.

    :)


    YMMV

    in reply to: US Importation …. Legal or Not #5023
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Yes, we have some ideas but I can only tell you in the cone of silence! Your shoe phone may have been tapped!


    YMMV

    in reply to: The Correct Weights To Use #4955
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    All the trial data (past Phase 1) typically relates to the chosen dose and a 2 DAA combination of Sof+Dac or Sof+Led (+/- Riba)

    All drugs have a therapeutic window which is discussed here:

    http://fixhepc.com/forum/experts-corner/164-resistance-and-treatment-failure-mechanisms.html?start=6#1122

    and here:

    http://fixhepc.com/forum/experts-corner/232-diy-dose-adjustment.html#1776

    So for most people 10% either way is not going to make any great difference.

    On the time aspect we do see 16 weeks working better than 12 so there is just no way I would leave spare pills un-swallowed but I would stop when I ran out of the other 1/2 of the combo

    Chances are you will do well, but if you draw the short straw and have to retreat it’s not like it’s the end of the world as we know it. This is the end of the world as we know it…..

    [video]https://www.youtube.com/watch?v=Z0GFRcFm-aY[/video]


    YMMV

    in reply to: HCV New Drugs Blogspot #4935
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Dang, we will be mainstream before we know it!


    YMMV

    in reply to: Emilio’s Place #4928
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I confess that I knew very little about Hep C, and how one would catch it, when I was diagnosed (after an iffy LFT and then routine bloods taken by my Doctor). I had no conception of its implications etc. Anyway after much reading (and scaring myself half to death) I took the bull by the horns so to speak and arranged to have a Fibro scan and Ultrasound done. Thankfully those results came back good and apparently I have only a fatty liver at the moment (this was back in February/March). A work colleague bought in an article from The Age on the Buyers Club and the rest is history. I am in my third week of treatment and will have the all important blood test next week.

    I have absolutely no idea how I contracted the virus and I guess it doesn’t really matter now but in the early days I really wanted to know so I would have someone to blame for it……I doubt I will ever find out now but I sure do want to make people aware that Dr Freeman and his team and also Em (who has been a great support to me) are there to help. I did follow Greg Jeffrey’s blog for a while as well.

    I don’t judge anyone and at the end of the day it really doesn’t matter how people catch it, it is now about curing it!!

    Cheers Lynne :)


    YMMV

    in reply to: strange translation of fixhepc on my computer #4917
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    The best you can do to get smileys line up is to put them in the same row of a table (you need lots of TD (table division) things in the same TR (table row)

    :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol:

    YMMV

    in reply to: Emilio’s Place #4896
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    :cheer: :cheer: :cheer: SO HAPPY for you Em, you are an inspiration and truly a decent caring person. I know you will help so many more heppers as you have helped me move forward to reach for healing. Thank you a million times, and thanks to Dr. James and crew. The facebook page sounds like a great idea and hope you can reach out to many more.


    YMMV

    in reply to: GT3: High SVR rates with Daclatasvir #4886
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    While on the surface you might think that more is more, as in:

    1 + 1 = 2

    With antibiotics we know that is not always the case.

    Take penicillin. It is what is known as bactericidal – it punches holes in bacterial cells walls and the bacteria explode.

    Take tetracycline. It is what is known as bacteriostatic – it does not kill it just arrests growth.

    Now the problem is that for penicillin to work the bacterium needs to be active, so if you add tetracycline it actually works WORSE

    1 + 1 = < 1 Here is some systematic research that talks to it: http://www.ncbi.nlm.nih.gov/pubmed/24867991

    The thing with this data is that the n was pretty large and in the 24 week groups there is not a single case where Sof+Dac+Riba out performed Sof+Dac alone.


    YMMV

    in reply to: Emilio’s Place #4877
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    That’s awesome Em….go you!!!


    YMMV

Viewing 15 posts - 1,711 through 1,725 (of 1,968 total)