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Hello Hopeful425, sorry to hear about the headaches.
Yes liver twinges are very common on treatment and immediately after. There is a lot happening in there!
YMMV
Hello Hopeful425 it should be ok, but I do tell my patients you can’t get problems from drugs you are not taking…
YMMV
Hello MikeMike,
There is no problem for you having dental work and having local. The local will work, the treatment will not be impacted – take your dose as usual.
At 4 weeks into treatment there is an 80% (4:1) chance you are undetectable so non infectious. There should be universal precautions so your blood, even if still detected, should not cause any risk to staff of other patients.
Often patients who mention having Hep B, HIV or Hep C will be scheduled at the end of the day. This should not be necessary if correct procedures are followed.
YMMV
Hello Austincr,
Thanks for sharing your experience and great to hear you’re feeling better.
Best of luck for your SVR12!
YMMV
Hello Vikramb,
Your doctor has made a good prescription – the SOVIHEP-V is Sofosbuvir/Velpatasvir which is known as Epclusa. It is a very good choice for treating genotype 3.
Your mothers low platelets and high prothrombin time suggest reasonably advanced liver disease, but we would expect the treatment to be successful and her quality of life to improve.
Using ribavirin is a good idea but can have some side effects – we need to keep an eye on FBC in particular to make sure no severe anemia or low platelets happen – if so we need to reduce/stop ribavirin.
The Ribavirin dose is usually 1000mg/day for patients <75kg and 1200mg/day for patients >75kg. This is taken 1/2 in morning and half at night so either
3x200mg morning + 2x200mg night (1000mg total)
3x200mg morning + 3x200mg night (1200mg total)The low energy and swelling of legs probably relate to the liver problems.
YMMV
Hello Mike,
Relax, the evidence says smoking marijuana or drinking alcohol during treatment will not reduce the treatment success rate.
https://www.ncbi.nlm.nih.gov/pubmed/30944519
Sadly about 1 in 5 patients get some insomnia. Here’s my quick tips on how to deal with insomnia
https://fixhepc.com/blog/item/82-how-do-i-fix-my-insomnia.html
Weed’s not listed in the medication options but, hey, it’s natural and if it’s working for you…
YMMV
These dressings look perfect. You can leave them on for a full week unless they look too wet underneath.
You won’t really need the Bacitracin but it won’t hurt if you use a little.
YMMV
Hello Kaju,
I’m sure everything will be fine.
Best Regards
James
YMMV
Best of luck Anton! The wait can be a bit nerve racking but the odds are stacked in your favour.
YMMV
Bacitracin is ok because it’s an antibiotic cream, rather than an antiseptic.
Antiseptics kill everything – killing the bacteria is fine, but killing the healing skin is not.
Antibiotics are targeted, so leave the healing alone.
YMMV
Hello GaryC123,
Sorry to hear about your brother and this rash.
It certainly could be a drug reaction rash for which the mainstay of treatment is stopping the drugs.
Once these sort of blisters have formed there is nothing we can do to make them go away. They will eventually pop, but for preference should not be popped – the dead skin layer over the top of the fluid protects the sensitive layer below.
We do occasionally use steroids like Prednisolone 50mg daily for 3 days to get things to settle down.
Anyway, this should be treated like a partial thickness burn.
You can use an antiseptic cream, but only for 24 hours. All antiseptics delay healing.
All we really need to do is keep it clean AND not get it infected – it should heal rapidly with no scarring.
In a hospital environment, we would put a dry alginate dressing over the area and cover it with Hyperfix. This would be kept intact for about 3 days before looking at it again and redressing.
The low-tech approach would be clean well fitting cotton T-shirts changed every 24 hours . These would be likely to stick a bit but taking them off in the shower, not touching the area and letting it air dry before covering with a freshly laundered clean T shirt would do a reasonable job (in a pinch)
YMMV
Hello GaryC123,
The first page is referring to your Hep C Antibody level. This is positive because you have been exposed to Hep C. A person not exposed would be <1, you have been, you have a value >1 because you have been exposed to Hep C.
The second page is the Hep C PCR RNA test and the <15 level indicates the virus is not detectable. This is good, it means you do not currently have any Hep C virus in your body.
Either you have spontaneously cleared the virus (25% of people do), you are on treatment, or you are in the post-treatment SVR period.
YMMV
Hi Howard,
The alternative to waiting would be to do a CMP privately. It’s pretty inexpensive. Here’s a link to a number of lab providers in the USA
These ones don’t need a doctors order:
- http://www.directlabs.com
- https://www.discountedlabs.com
- https://www.econolabs.com
- https://www.ultalabtests.com
- https://www.walkinlab.com
YMMV
Hello Howard,
It would be useful to see your full tests, but that said…
With alcohol, we normally see an isolated rise in the GGT liver enzyme with the AST and ALT enzymes typically being normal. In some patients who drink a lot we may see all of these rise but typically we are not talking moderate drinking, we’re talking bottle of scotch, 2-3 bottles of wine, case of beer a day level consumption.
One of the first things I do when presented with unexpected abnormal test results, somewhat as a knee-jerk reaction, is simply to order them again. It’s surprising how often the repeat bloods come back normal. If they do I just shrug, make a note to keep an eye on it for a while, and we move on with a “dunno what it was but it seems to be gone now”. If on the other hand the repeat comes back abnormal it depends on whether a) things are getting better in which case I would typically just monitor it to see it normalise or b) things are getting worse in which case I would start looking for the cause.
re_roll has suggested an HbA1c which is the 60 day rolling average of your blood sugar levels. This is probably less useful to you right this second because if your blood sugar has not been up for long this won’t be up yet – it needs a solid 60 days delay.
Repeating the blood sugar, and CMP nowish would be a useful first step. There are lots of other tests we could add in but if the repeat is normal(ish) a watching brief is probably on the cards.
Besides alcohol there are literally thousands of other things patients take that can impact the liver. “Healthy” supplements can be the cause, for example green tea extract is known to cause liver failure when taken in excessive supplement level quantities, so a key question would be
Besides starting to drink again have you added in any other “drugs” where this would include prescription, non-prescription and supplements – anything that goes through your mouth that is not routine food.
There have been outbreaks of Hepatitis A all around the world, often associated with frozen berries, so it could be you’ve got a dose of that from a berry smoothie…
Anyway, step 1 is repeat the CMP +/- the BSL so we can see if things are trending better, or trending worse.
YMMV
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