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Viewing 15 posts - 571 through 585 (of 1,968 total)
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  • in reply to: Latest HCV treatment information from a panel of experts #27240
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Polyps in the gallbladder will not cause any problem with treatment.

    These polyps should however be watched to make sure they do not change size.


    YMMV

    in reply to: Flu-like symptoms #27235
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello catemae,

    It is pretty routine. Some patients notice next to nothing, but what you describe is very common.

    It would be worth having about 3 litres of fluid a day and some regular ibuprofen 2 x 200 mg 3 times a day – both these will help you feel better.

    You are right that it’s best to avoid antacids with Harvoni where possible. The occasional dose will do no harm, but less is more.


    YMMV

    in reply to: Flu-like symptoms #27233
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Catemae,

    Yes this is most likely related to the medication.

    While you can get a cold or flu at any time – before, during and after treatment – the start of treatment is often exactly as you describe.

    What I tell my patients to expect is this:

    You know that feeling you get just before you are about to get flu? Muscle aches, joint aches, headaches and feeling a bit miserable. That’s what the start of treatment is often like and happens because you are killing off all the virus. It usually only lasts for a few days and responds to increased fluids, and simple analgesics like panadol (tylenol), aspirin, nurofen.

    It should not last too long and will hopefully be better tomorrow that it was today.

    As far as grumpy boss goes if you turn up looking sick and then say you have to go home it makes it very evident you’re not having a sickie…


    YMMV

    in reply to: RNA came back positive and going to GP in 2 days #27227
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    With Canada, medication coverage is a bit spotty. With any luck you will qualify under the local rules. If not generics can be shipped in directly but go for the free stuff first!

    Either way you’re welcome to hang out here. Treatment can get a bit lonely given the stigma.


    YMMV

    in reply to: RNA came back positive and going to GP in 2 days #27225
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Sharmon,

    With GT1a you have lots of options, all good, all with minor pros and cons. If you are low fibrosis then 12 weeks is all that is required with any of them. 8 weeks with Mavyret.

    Sofosbuvir Based (in order of preference)

    1) Sovaldi (Sofosbuvir) + Daklinza (Daclatasvir) – my personal preference (low sides, good cure rate and cheapest as a generic)
    2) Harvoni (Sofosbuvir + Ledipasvir)
    3) Epclusa (Sofosbuvir + Velpatasvir)

    Non-sofosbuvir based (in order of preference)

    1) Mavyret
    2) Zepatier
    3) Viekira + Ribavirin

    Note that, perhaps with the exception of Zepatier, all are expected to deliver 95% cure (20:1 odds).

    What country are you in?


    YMMV

    in reply to: Latest HCV treatment information from a panel of experts #27223
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    With GT4 I would definitely go with Sof/Dac. It is cheaper and better than Epclusa and the evidence it works in GT4 is huge with 1,000,000 treated with it now.


    YMMV

    in reply to: Hi There, gt2 and new here #27216
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Vedrus I had the same genotype as you. Took my course of meds and have been cured. Only side effect was insomnia but other than that I breezed through the treatment, as I’m sure you will. I look forward to seeing your progress.

    Cheers


    YMMV

    in reply to: We need your help! #27214
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    YouTube will display captions in you language if

    A) You are logged in and have set your language preference

    B) Captions in your language are available

    http://www.3playmedia.com/2014/11/07/language-will-youtube-captions-display/

    You can force it like this by adding

    &hl=es&cc_lang_pref=es&cc_load_policy=1

    To the end of the video URL which would force “es” which is Spanish. “ro” is Romanian so

    &hl=ro&cc_lang_pref=ro&cc_load_policy=1


    YMMV

    in reply to: Took darvoni from beacon and failed #27209
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    All you need to do is this:

    Using Google Chrome, and on a computer with Camera, Mic and Speakers login to https://gp2u.com.au/ and go to the waiting room. Allow the use of Camera etc and it will just work.

    Alternatively, go to https://gp2u.com.au/ on a mobile device and get the iOS or Android app. Login on the app, go to the waiting room and start the video….


    YMMV

    in reply to: Hi There, gt2 and new here #27208
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello vedruss,

    The fruits known to interfere with Daclatasvir metabolism include grapefruit, pomegranate, starfruit and pawpaw. These all inhibit the enzyme CYP3A4 which is involved in the metabolism of Daclatasvir. Because they inhibit the garbage collection we see higher blood levels and side effects.

    CYP3A4 inhibitors DO NOT impact on treatment efficacy. The higher levels probably work slightly better but at the price of more side effects. To get problems you really need to consume them daily, so although not recommended the occasional fruit in this class will not hurt.

    http://www.ganfyd.org/index.php?title=Inhibitors_of_CYP3A4

    Of more concern are CYP3A4 inducers – these increase the garbage collector levels and thus lower the blood levels. Lower levels may result in treatment failure.

    St John’s Wort and Taurine (Red Bull and friends) are potentially common problems.

    There are, of course drugs that act as inducers and inhibitors as well. Here is a more global overview:

    https://en.wikipedia.org/wiki/CYP3A4


    YMMV

    in reply to: We need your help! #27207
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I’ve been doing a lot of clicking :-)


    YMMV

    in reply to: Harvoni and arthritis symptoms #27203
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    For people who can’t afford orthotics a well-fitted pair of running shoes are the next best thing and can typically be found almost anywhere.


    YMMV

    in reply to: Took darvoni from beacon and failed #27201
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Pctree,

    Just login and book an appointment with Dr James Freeman


    YMMV

    in reply to: Took darvoni from beacon and failed #27199
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Pctree,

    The 6 pm is your local time. It’s about 9 am for me.

    Let’s have a chat about it all tomorrow…


    YMMV

    in reply to: Hi There, gt2 and new here #27196
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Welcome vedruss,

    You have come to the right place. Plenty of support and of course access to the new meds. The new treatments are like chalk and cheese compared to the old ones.

    If you can get your local doctor to prescribe that’s great, if not, you can see me online and we can make sure you get the right tablets for the right quantity of time. Just register at https://gp2u.com.au/ and book an appointment with me if needs be.


    YMMV

Viewing 15 posts - 571 through 585 (of 1,968 total)