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Viewing 15 posts - 676 through 690 (of 1,968 total)
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  • in reply to: Thank You Doc Freeman #26433
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Woobia,

    The army will only let 18 yo recruits carry 25 kg because if you load up their young bodies with too much more they wear out.

    You’ve loaded yourself up with that, but you can’t just take it off for a breather!


    YMMV

    in reply to: Are you up for it? #26426
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    your-story-is-the-key.png


    YMMV

    in reply to: Seriously worried that I may have relapsed #26424
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello RSF,

    Really happy for you! One of the things I’ve noted over the years is my personal tolerance for excess alcohol or caffeine has gone down. Anything much over 4 standard drinks (2 typical bucket glasses :-) or 1/2 a bottle leaves me the worse for wear. Coffee after midday and I don’t sleep.

    Youth, I say, is wasted on the young!

    Sleeping away all those awesome teenage years – what a waste!


    YMMV

    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    The Guardian have at least had the decency to publish several contrary letters:

    https://www.theguardian.com/society/2017/jun/13/hepatitis-c-antiviral-drugs-are-effective


    YMMV

    in reply to: Day 1… here we go #26414
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Update for those interested: SVR 4 :+1:

    May your 4 be followed by 5 more. Amen.


    YMMV

    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I find it staggering that the Cochrane researchers even came up with the idea that the question of long-term benefit could possibly be addressed by looking at short-term studies specifically designed to look at a different question.

    In our first group of patients, there was only one, who asked (and got) his medications without the added expense of individual testing. I worryed about that for 2 weeks until he called up and said:

    “Hey Doc, you don’t have to worry about these medications”

    I said “How’s that?”

    He said, “It used to be after a morning on the tools I’d have to take a nanna nap”

    [He was a bricklayer and could only manage a morning’s work before he had to have a sleep] (Translation from Australian slang)

    Then he said, “Now I can go all day. It’s like I’m 20 years younger. One of the young fellas even came up to me and asked ‘Hey boss, what are you taking, can I get the connection?’ I told him ‘Not those kinda drugs mate'”

    So while there are some patients who don’t see fantastic improvements, and there are some patients that get side effects, in my experience the results of treatment are so clear cut you read the Cochrane thing and go “WTF are you guys smoking?”


    YMMV

    in reply to: Cleared Hep C after 34 years #26399
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Welcome to the forum Dixieleeg.


    YMMV

    in reply to: Constipation with Daclatasvir/Sofosbuvir #26388
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Heatherlou,

    All across medicine we see issues with bowels. There are many options to help regularity.

    For me a cereal called sultana bran works wonders, but….

    Psyllium husks for fibre are on the natural side.

    Lactulose is a non-absorbable sugar that sucks water into your bowels and works as a flush. The advantage is you can dial the intensity up and down easily. 10 ml once a day is like the ultra low setting and 20-30-40 ml two-three-four times a day gets you to power flush levels. If you dial it up too much you simply dial it back a bit.


    YMMV

    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    And an after thought, what are DAA’s supposed to do other then clear the virus, guarantee a lottery win as well??

    Yes, a proper title for this study would have been DAA therapy is no more dangerous than placebo.


    YMMV

    in reply to: keith’s retreatment #26382
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Kieth,

    I look after any patient who needs retreatment personally.

    It’s quite a long discussion about the options – from wait a while through to here are all the currently available options.


    YMMV

    in reply to: Fibrosis F4 #26381
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Sonja,

    The ALT and AST are fine – they wander up and down a little in everyone.

    Yes, the cholesterol is a little high. Over time this can be a problem and it is high enough for me to discuss treatment with a Statin class drug with my patients.


    YMMV

    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Please see my blog post about it here: http://fixhepc.com/blog/item/81-bad-science.html

    Yesterday the Guardian published and article called ‘Miracle’ hepatitis C drugs costing £30k per patient ‘may have no clinical effect’

    https://www.theguardian.com/society/2017/jun/08/miracle-hepatitis-c-drugs-costing-30k-per-patient-may-have-no-clinical-effect

    The problem with this sensationalist headline is that while it is reporting what was said by the Cochrane Collaboration what they looked at was trial specifically designed to test SVR rates, and not specifically designed to look at long-term outcomes.

    Here is a commentary from Dr Andrew Hill and the study to which he refers which was presented at AASLD in 2015 and published in Clinical Infectious Diseases.

    Total rubbish! Here is our paper showing a really strong correlation between curing HCV and improved survival.

    They only had 16 deaths included in the analysis!

    Please see the attached paper where we had much longer follow up and showed a strong effect of SVR on improved survival. Our analysis included 2210 deaths – slightly more than the Cochrane study!

    Here is Dr Hill’s AASLD presentation:

    AASLD_Outcomes_Oct30x_SLIDES.pdf

    And here is the full journal article from Clinical Infectious Diseases:

    HepatitisCureSurvival.pdf


    YMMV

    in reply to: Buying twinvir for hep c #26356
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Michaela & Bogdan,

    I want the same for my friend in Italy. What is cost for Twinvir. Can you write here or send me personal message. I was cured with Indian Medicine. But if Twinvir is cheaper i will buy that for my friend.


    YMMV

    in reply to: Buying twinvir for hep c #26351
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Yes if it is alimul@inceptapharma.com He also uses the email hasan.pr33@gmail.com

    He works for Incepta and is trustworthy. I have known him since October 2015 and he has never let anyone down.


    YMMV

Viewing 15 posts - 676 through 690 (of 1,968 total)