Weight makes no difference to cure rate

We have 100% success in GT6 with Sofosbuvir Daclatasvir but sample is only 6/6 – so 6 patients total.

So it is possible and cure is likely

Hi Graham,

I have a couple of online appointments free tomorrow, so if you want to book on we can have a chat in detail.

https://gp2u.com.au

Hi Janet,

I would not be surprised if the flare up of your arthritis is actually gout. I’ve seen a few case of that.

By the numbers you are chancing it with GT3 and F2/3 and 12 weeks. I would have suggested at least 16 if we’d been chatting about it before starting.

The two things in your favour are the undetected at day 26 (undetected here doubles your chances of SVR) and being a woman (also doubles your chances of SVR). You viral load on the other hand is the highest I’ve ever seen in a GT3 which increases the statistical chances of resistant clones.

It would be feasible to get a 4 week extension treatment of Sof/Vel to you before you run out of medication.

Hello Elena,

People forget that just because you have HCV, it does not mean you have no other problems.

While HCV and HBV are common reasons for liver functions to be up, haemochromatosis and 2 dozen other things can cause it. Here is the big list:

http://www.mayoclinic.org/symptoms/elevated-liver-enzymes/basics/definition/sym-20050830

We do normally see a good drop of ALT/AST. In you we have not seen that, which raises the question if it is not HCV (and if we do a viral load I expect you to be undetected) what is the cause?

Although it is rare with Sofosbuvir/Daclatasvir with drugs like Viekira and Zepatier it is very common to see liver functions get worse on treatment. This is a reaction to the drugs so it is possible that Twinvir itself is causing it.

Anyway it is nothing to panic about, but does need looking into further, probably after you finish the Twinvir.

Hi Matt,

Your specialist should feel pretty good about it, and anyone who’s read some of the stuff he knows he’s a 1:1000 kind of a doc willing to put his patient’s interests before personal considerations.

Congrats on the results. Hearing about SVR just never gets old!

Hi Edge, that all sounds to be on track. Good luck for SVR!

And one more

https://www.youtube.com/watch?v=yQ7MNErsMGk