MexicoBound,

The 60Mg filled about 1/4 of a 00 capsule.

You must repack the daclatasvir at a weight of 66 mg – this is required to get the 60 mg of free base. If you don’t you will be under dosing.

This will use 5.6g of the 8g you have purchased.

You should not take the remaining 2.4 g in isolation ie without Sofosbuvir where the 34 g is the correct quantity for 84 x 400 mg

The story I heard was that the Health Minister wrote to Gilead asking to be added to the list of 91 approved countries for generics.

Having not received the courtesy of a reply he authorised local production…..

With any new drug many impacts are unknown.

If you search for “sofosbuvir semen” on Google you will only find 2 results.

Sofosbuvir was previously known as PSI-7977 and GSI-7977 so you should also search for

pharmasset psi-7977 semen

gilead gsi-7977 semen

The last search yields this result: http://www.natap.org/2014/EASL/nejmoa1316366_protocol.pdf however the excretion in semen refers to Ribavirin.

Anyway in the absence of documentation saying it’s not in semen you would be safest to refrain from trying to have children during treatment. The logic for how long to wait after treatment see:

http://fixhepc.com/forum/experts-corner/872-how-long-should-i-wait-after-treatment-before-getting-pregnant.html

I know this is out there Doc but is there a therapeutic dose that could be considered for G3’s who relapse just to keep the virus in check once it’s cleared ?

In the dose scoping trials (with PEG+Riba) the 200 mg dose of Sof saw only 94% UND at EOT, but with 400 mg it was 100%. SVR rates were 90% and 91%.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968818/table/table1-1756283X13515825/

Conclusion: We see virological breakthrough in 6% of patients on low (200 mg) dose Sof so 400 mg daily is where it needs to be.

You can’t change it, but we can. What would you like it to be

So the hardest to treat strain is now GT3?

Yes, without any doubt. Although the DAAs are better than PEG/Riba across the board, PEG/Riba used to do best in GT3 and is still an option for salvage with Sofosbuvir.