Without knowing your full history, and based on what’s in your signature you should be ok on 12 but the odds of SVR are improved significantly by longer treatment. If extending out to 16-18-24 weeks would not overburden your finances it is worth doing with GT3.

Hi Cindi That’s great news for your friend……glad to hear he is now on treatment and kudos for yourself and your husband for getting him this far.

What awesome news about J….and a girlfriend too…….he couldn’t go wrong with a Mum like you that’s for sure!!

I’m having my blood test for SVR12 done in three weeks……so not far behind J. Here’s to undetected!!

Congratulations Ariel ……ahhh the Palais Theatre …..saw Moody Blues there and the late great Joe Cocker……what a magical place you live in……beautiful ocean and beaches and green grass!! I’ve forgotten what green looks like here in Bendigo….28 acres of barren land, skippies eating anything they can find to stay alive….. Enjoy your UND!!!! So glad you are feeling better.

Sofosbuvir 40g 520usd totally include shipping cost by express
Ledispavir 8g 400usd totally include shipping cost by express

You have too much sofosbuvir and not enough ledipasvir for 12 weeks treatment,

You need 400 mg per day of sofosbuvir (that is 34 g for 12 weeks)
You need 96 mg per day of ledipasvir acetone to deliver 90 mg of free base (that is 8.1 g for 12 weeks)

You should take it at night, without food, particularly if you are going to under-dose the ledipasvir, which you are, given you don’t have enough.

Proton pump inhibitors should not be taken before ledipasvir/sofosbuvir.” Shoud I skip it ?

Yes, if you can skip it, absorption of ledipasvir needs stomach acid. You only get about 1/2 as much in if you don’t have stomach acid (at least if you were a dog taking famotidine (which is not a PPI but works like one)).

With Amlodipine:

Coadministration has not studied but may increase concentrations of amlodipine or ledipasvir due to P-gp inhibition. Although a clinically significant effect of ledipasvir is considered unlikely, monitor heart rate, blood pressure and for increased side effects of amlodipine.

So it will probably be OK. Keep an eye on your BP, and if you seem to be getting sides past the first week we should consider if you are getting higher levels of Ledipasvir (and no using a PPI to reduce them is not a good idea!)