Forum Replies Created
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Here ya go!
https://fixhepc.com/forum/technical-support/977-how-to-add-signature-details-to-your-profile.html
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G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Keith,
My understanding from when I was on riba is that there are two reasons for the food, one is that riba can make some people nauseous on an empty stomach. The other, probably more important, is that riba is absorbed by our bodies better in the presence of fats. I’d suggest at least a light snack containing some fat. Some toast and PNB or maybe cheese and crackers with your coffee?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Phew, that’s a relief…….
Aaaaah!!! That’s better.
(It appears the recommendation refers to reducing Harvoni side effect of headaches rather than reducing the medication’s effectiveness.)
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
coral wrote:…..I had a phone call today from Dr James to say that I am SVR12
Coral, that is wonderful news! So happy to hear it.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Gert wrote:Jeg skriver dette opslag på dansk. (blevet opfordret til det fra fixhepc)
Overvejer du selv at købe HepC medicin?
Har du spørgsmål i forbindelse med at selv at købe din hepatitis C medicin hjælper jeg dig meget gerne med at du får kontakt en pålidelig sælger af HepC medicin.
Jeg har lavet en vejledning inden købet:
her er et uddrag af vejledningen.Før købet:
Spørg sygehuset/egen læge om de vil monitorerer (tage blodprøver) under din behandling hvis du selv kommer med medicinen. Blodprøve dagen før du starter, efter 4 & 8 & 12 uger
den ”store” test 12 uger efter behandlingen er slut samt 24 uger efter og den sidste 1 år efter.Blodprøve:
Få at vide hvilken genotype du har:
46 % genotype 1 (G1a (34 %); G1b (12 %)), 43 % genotype 3,
8 % genotype 2 og 3 % genotype 4; genotype 5 og 6 er sjældne.– få målt dit virus tal (virus mængde)
– hvad er dit ALAT tal? (Alat er en organmarkør, normal området for mænd er 10-70 / kvinder 10-45)Få lavet en Fibroskanning – skal være 10 eller derudover før du får tilbudt behandling i Danmark.
Skriv en privat besked herinde så kontakter jeg dig
Vi fortjener alle at få et liv uden HepC
ick:' /> (Opfordring til Fixhepc webmaster at ligge dette opslag et sted hvor det er lettere at finde for mennesker fra Danmark)
Hi Gert,
Thanks. I moved your post above to its own thread as requested with the title in your language so other Danes who come here can see and read it.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Great news Gert!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Welcome heatherlou30,
As the others say, if you sourced your medications from FixHepC as part of one of the Redemption Trials then you have nothing to worry about. Please let us know if it was from an alternative source.
Regarding the repeat script, usually this is provided as part of the original prescription written by the prescribing doctor based on the required treatment plan length that is most suited to your genotype and liver condition and should have been discussed with you at the consultation when the script was issued. It is normally provided to the patient at the time the original script is filled and while many patients fill the second one immediately to ensure supply it should not be a problem to complete it closer to the required date but remember to allow plenty of time for shipping so there is no gap in your treatment.
As “your doctor” does not appear to be fully aware of the above it sounds like your current (monitoring) doctor may be different from the one who prescribed? This is not unusual so you should ensure that the monitoring doctor is up to date on what the prescribing doctor told you and the monitoring requirements involved. If you look at the top of this page you will see a tab titled GP Cheat Sheet which may assist your current doctor with the monitoring process.Hope this assists and please ask if you have any further questions..
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Janet,
The short answer is that Sofosbuvir has a half life of about one day (27hrs) so the approximate concentration in your body halves each day once you have finished treatment. Eg.
EOT 100%
Day 1. 50%
Day 2. 25%
Day 3. 12%
Day 4. 6%
Day 5. 3%
Day 6. < 2% Day 7. < 1% Daclatasvir's half life is 12-15hrs so will clear from your body twice as fast so both these meds are mostly gone from our bodies very quickly. Here is a more detailed explanation from Dr Freeman on how long it takes before Sof/Led are completely gone.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Congratulations vanh, wonderful news.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Elena wrote:Thank you, all!
I have red some articles related to the side effects of this combo Sov+Led, and they are a bit concerning… Did you hear or experience any really bad side effects?
Hi Elena,
I don’t know which articles you have read but please keep in mind that the overwhelming majority of people on forums will treat, have few sides, reach SVR and move on with their lives rarely posting afterwards. However this does mean that the few who do experience stronger sides appear to be more highly represented than is actually the case.
It is worth keeping in mind that many HCV patients are in their 50-60s and have had this virus for many years. Reaching SVR will prevent further damage by the virus but may not totally repair damage already present and won’t stop the natural ageing process. That any of these issues occur around the same time as treatment doesnt necessarily mean they are an effect of the medication so any health concerns during and post treatment should be discussed with a doctor. Here is a link to some previous comments about side effects from Dr Freeman that you may find useful: https://fixhepc.com/forum/daa-side-effects/1324-frigtened-by-possible-severe-irreversible-side-effects.html#21969
Regarding shortening your treatment, while it is true that Harvoni has been approved for 8 week treatments in low viral load patients like yourself it does still give lower results in those patients than treating for the full 12 weeks. Assuming that your sides have been tolerable so far ? my recommendation, like the others, is to complete the full course of treatment, this will give yourself the very best opportunity to achieve SVR and not require retreatment.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thanks Iain,
Change to quote. I have enough trouble remembering my password so shouldn’t expect others will either!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Congratulations on SVR12!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi countless,
U/S looks for abnormalities such as growths and changed blood flow and can also show granularity and other signs of extensive cirrhotic scarring but doesn’t tend to pick up fibrosis or inflammation very well. Gastroscopy looks for evidence of portal hypertension. That no issues showed up on either of your examinations is good news.
Fibroscan measures the stiffness of the liver and as you were a F3 this would probably have been due to a combination of bridging fibrosis and inflammation. Inflammation tends to resolve with treatment and the evidence from studies seems to show that for many of us the fibrosis will also decrease over time after successful treatment. Perhaps you can get another fibroscan in say 6-12 months to check?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi countless,
There have been a few reports of increased blood pressure on treatment here but I’m not aware of a direct causal link to these medications. I am on blood pressure medication and during treatment mine rose at first but didn’t reach alarming levels so we monitored it and it settled back down again over the next couple of months and has stayed okay with my normal BP medication since then. Perhaps it was an effect of the HCV medication? Or maybe just the ‘excitement’ of being on treatment and all the emotional implications that brings for most HCV patients?
As the others note, many of us are of an age where health issues like high blood pressure start to surface regardless of whether we have HCV. Please keep in mind that most people (including myself) “feel no different” when they have high blood pressure so I would recommend that you consult with your GP for a check and follow their advice.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Welcome Bogdan,
Sovaldi (Sofosbuvir) on its own is not sufficient to give you the best chance of cure, it will require use in combination with a second drug. Both Harvoni (Sofosbuvir+Ledipasvir) and Sofosbuvir+Daclatasvir are very effective for treatment naive 1b patients with the SVR Calculator https://fixhepc.com/getting-treated/svr-calculator.html showing clinical trial results of 99.1 and 100% with the difference likely being statistical but you should contact FixHepC at help@fixhepc.com for the most current information on which is most suitable in your circumstances.
As with most medications there is potential for side effects but many people find both these treatments fairly mild and any effects seem to vary from patient to patient more than between the drugs. This isn’t to negate the comments from those who do experience difficulties but it is human nature that those with sides will be more likely to post online about their experiences than the majority who have no problems.
Looking forward to hearing of your successful treatment.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
