Forum Replies Created
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I should note that it may be that he feels that the outcome of 12 weeks treatment for you is likely to be more beneficial than the full 24 weeks. But again he really should be explaining that in a way that you can understand the impacts and consequences, and agree with.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Okay, just realised you are genotype 2b and the data I was thinking of is for 3a.
Im not a Dr but assuming your specialist is a hepatologist then he is presumably up to date and knows your history particularly regarding your cirrhosis and the best option for you and your health. However, he appears not to have convinced you of the veracity of his information. If it was me, I would be telling him that he needs to show me the data that is causing him to change his mind at this stage of my recommended treatment and convince me as to why I should now change that treatment. After all it would be my health and wellbeing that was effected by his sudden change.
It appears you have about two weeks of the current script left? Are you already in receipt of the second script?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Abathnot & welcome,
You are doing fine with posting here. There was some new data out of Europe late last year which he may be referring to.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Since a week before Xmas I have heard a number of media statements promising something along the lines of ‘All patients over 18 years of age will be eligible from the 1st March’. The idealist in me would like that to mean: “All patients will receive treatment within a reasonable time of applying for it.”
Hopefully we get some idea of the reality soon.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi and welcome Yasir,
Thank you for the information supplied.
As it has been a while since we added a new profile to the Pharma’s Market area I would just like to remind our members and guests to read our policy for this section http://fixhepc.com/forum/daa-access/457-warning-to-online-buyers.html
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi and welcome,
Also not a Dr but with the one cup you will be fine, liquorice has been identified as a cyp3a4 inhibitor but I couldn’t find anything on how strong the effect was. As splitdog says and given you are only two days into treatment that won’t be a problem, just don’t keep drinking it. If you search the site for “CYP3a4” you should find plenty on what items to avoid.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
While not wanting to detract from an important discussion, I think we need to be careful how we define some of these issues. Many (most?) people who treat and achieve SVR will just want to forget about their past illness and move on with their new life, never to post again. That is their right and entitlement but it does mean that those few who do have problems post treatment will appear to represent a larger proportion than they actually do. Also, a month post treatment is probably not really representative of final outcomes for SVR as with most illnesses and injuries we expect a post recovery period when while no longer actually ill we are still not back to our former selves. Given that most of us have had HCV for several decades, my own thought is that it likely to take months or even years for some to fully recuperate. And as Mike points out, we have aged since we aquired this virus so can no longer expect to feel like in our teens.
Having said that I also believe we all need to be mindful of our health going forward and have follow ups as necessary taking into account our HCV medical history particularly if we had high fibrosis/cirrhosis. And if we have health issues that don’t correlate with our peers in the general population then we should investigate those as and when they occur.
edit: Ariel’s post above reminds me that those who had unpleasant experiences with interferon need to be particularly mindful of follow ups in the future.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi berrinice,
There are many things that can cause edema so it may or may not be related to your treatment. How urgent will depend on the severity and whether you did anything that could cause it like a lot of walking so please seek medical advice on that basis, any doctor will know what to check based on your history and how you present.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Archer,
Melatonin is a hormone that our bodies make naturally in a daily rhythm which is likely why it is not included in the drug interactions charts. Apparently people in their 50s and older often don’t manufacture as much anyway which is thought to possibly be part of why we sometimes have sleep difficulties. So it seems to me that at the doses recommended we are just boosting our bodies own production and maybe changing the timing cycle slightly. I’m no expert but my assumption is that it should be fine to use occasionally as recommended during treatment. I find it helps if I take it for two or three days but then loses its effect, but that is usually enough to catch up my sleep/reset the pattern for a few more days. That way I reserve benzos for the “absolutely must have a good nights sleep so I can function for an important event tomorrow” occasions. YMMV.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi zhuk,
Wondering where you got to! Congrats on joining the UNDs mate, good to hear.
Best wishes for your Mum too.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
sonix wrote:That last article is curious considering BMS withdrew application for approval of asuneprevir (in combination with daclatavir) in Oct 2014 Because –
In clinical trials, BMS’s combination, on the other hand, cured just 82 percent to 90 percent of those with genotype 1b after 24 weeks.
Source – https://www.hepmag.com/article/asunaprevir-end-26284-925493039
I wonder what changed, as they are reporting higher SVR rates in this trial?
Looks like the 2014 report relates to earlier trials for approval for use in US so probably consisted mostly of western patient profile whereas these latest late stage trial results are for an all Chinese patient profile. This differing result is possibly to be expected as various racial groupings show differing responses to the old interferon treatments and also susceptibility to fibrosis/cirrhosis.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Welcome John,
That is a long journey but it appears you have done some good research into your next options. There has been discussion of availability of generic Simeprevir http://fixhepc.com/forum/media-news/225-merk-s-new-hep-c-drug-grazoprevir-elbasvir.html?start=18#8395. My understanding is that it is available though somewhat expensive compared with the other generics (but nothing like the price of branded product). As with the others, I would also suggest making an initial appointment at https://gp2u.com.au/ with Dr Freeman to discuss your options.
If you are unable to find any available appointments with him then an email directly addressed to him via help@fixhepc.com should assist.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Good job complete Dan!
Onwards to SVR!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Pat,
With suitable medication mine is usually maintained at about 110-120 over 70 something…..depending. Two weeks after I started Tx it had jumped to 150/90 which we monitored. It dropped back slowly over the next few weeks and by about 8 or 9 weeks was back to pretreatment levels. I don’t know whether it was a side effect of the meds or just my emotional/physical response to everything that was happening to me (even the act of measuring your blood pressure can make it change if you are worried about the result
).Also, most people need a type and dose size of hypertension meds that is somewhat tailored to them along with time to adjust to the specific dose. That medication will most likely be metabolised at least partly by their liver, so it is possible that the suddenly more efficient liver is then metabolising the BP meds much quicker than it did before. So maybe a need for a higher dose, a different med or a period of adjustment? All speculation of course.
Anyone with diagnosed hypertension should be monitoring regularly anyway but particularly on treatment and for others it doesn’t hurt to get your Dr to check you while attending monitoring visits.
Without wanting to sound flippant, the worse thing for high BP is worrying about it so get diagnosed and treated if necessary.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Okay, I’m not quite sure if you are proposing a mutual/insurance fund type setup that also covers something catastrophic like a liver transplant or just a ‘bank account’ that only covers you for what you have contributed in which case why not cut out the middle man and just invest your own funds as you see fit pending your need to draw on them if you can afford the treatment (the rich of course are still able to pay for their transplants).
If you mean a mutual/insurance type set up that will cover major events, then sure, you can probably set one up yourself keeping in mind that you will need a lot of members to spread the risk. That way each of you becomes a shareholder in that fund and any profits and interest are accrued to you as member/shareholders of that fund. There is your incentive. You may also want to open it up to non-shareholder members who are prepared to pay a non returnable premium for coverage. That will spread the shareholder members risk even further and probably be a nice little earner or at least pay the admin costs. Or you could join an already established insurance company as a member and also buy shares in the company and gain the same advantages of health cover plus a share of any profits without all the hassle of set up for yourself.
If just a cash fund then you have stuff all bargaining power to get cheaper health services and just as much likelihood that someone somewhere will be rorting the system to their advantage. If the mutual/insurance fund set up then regardless of whether you set it up yourself or invest in an established one then the bargaining power is what it is currently ($55k vs $96k for Harvoni I believe?) and someone, somewhere will still be using the system to their advantage rather than yours!
It is the people taking advantage of whichever system for their own motives that you need to identify and make the noise towards.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
