Christoffer, stop the kratom now. Dr. James mentioned that kratom might increase levels of one of the active ingredients of Epclusa to toxic levels:

It (kratom) is a potent inhibitor of a number of cytochromes including the CYP3A4 one that metabolised daclatasvir so would be expected to cause daclatasvir toxicity or increased side effects.

Better not to use any herbal supplements while taking Epclusa unless approved by your treating physician.

Hi Lisa,

You are doing well with Epclusa, these new DAAs are powerful drugs. I was one of the minority on Epclusa who experience extreme fatigue throughout treatment. I would not have been able to hold down a job. After treatment I returned to normal and almost a year later now I reached SVR24 and feel fine no problems. Best wishes!

DrJames,

Thanks for your advice. I underwent treatment with 12 weeks Epclusa: had serious fatigue as a side effect, but that was the DAA doing its job, everyone responds differently. Reached SVR24 so cured now. I did discontinue kratom use a month before starting treatment as the jury is still out it seems. Felt so much better after finishing Epclusa I never bothered with kratom again. Thanks for the service you provide to the Hep C community!