Forum Replies Created

Viewing 3 posts - 1 through 3 (of 3 total)
  • Author
    Posts
  • in reply to: Genotype 1b relapsed after Viekira+Exviera #28064
    mcmak
    • Topics: 1
    • Replies: 3
    • Total: 4
    • Novice
    @mcmak

    I have relapsed after Viekira and Exviera in November 2015, genotype 1b.

    Now I am waiting for Vosevi which I hope to get in October. I am still thinking if I should not take Ribavirin additionally. I do not want to take it.

    1. How many people from the forum where taking Vosevi for genotype 1b? Do you know anyone, any real-time data? If you know anyone on the forum please let me know.
     
    2. I am trying to explain WHY Viekira+Exviera did not work for the L31M. Is it supposed not to work for this well? 

    3. There is a table down in my letter from my blood tests after treatment- what does it mean
    Ombitasvir    |substitution on scored position  |       31M
    Does it mean that Ombitasvir that I was taking did not work for this?

    From my findings:
    NS-3 condones covered 1-181
    NS3 region (w.r.t M58335) – S7A, V48I, A66G, P86Q, K87A, P89S, F147L, V170l
    Ns3 region (w.r.t H77) – I35V, T42S,T61S, R62K, I64L, S66G, V71I,I72T, P86Q, Q89S, , S91A, I132V, A147L, L153I, N174S, L175M
     

    Resistance Analysis
    Drug     | Predicition | Scored mutations
    Asunaprevir | suspecitble | none
    Boceprevir | susbstituion on second position.   |   170I
    Grazoprevir | suspectible | none
    Paritaprevir| suspectible |none
    Simeprevir| substitution on scored position   |  170l
    Telaprevir |substitution on scored position | 170I
     
     

    NS5A condons covered. 1-104
    NS5A Region (w.r.t. D90208). – K6R, S17A, L31M, L34V, L37F,  G49A, Q54H, K68R, S101A
    NS5A region (w.r.t. H77) I8V, E14T, S17A, K24Q, A25S, M28L, Q30R, L31M, I34V, V37F, R44K, G49A, R56T, H58P, E62Q, K68R, T71S, R78K, R81S, M83T, S85H, L101A
     
    Resistance Analysis
    Drug         |     Prediction                                      |     Scored mutations
    Daclatasvir   | reduced suspectibility                  |      31M
    Elbasvir        |  resistant                                 |            31M
    Ledipasvir  |    suspectible                              |          31M
    Ombitasvir    |substitution on scored position  |       31M
     
    Velpatasvir      supsectible                                       none

    AND MY HISTORY:
    Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U start of treatm. After 2 weeks 120U. After a month below possib of detect. After 3 months UND.3EOT UND. 4wEOT RELAPSED,14Dec2016 VL 27000 IU.mL,Feb 2016 VL 24296 IU/mL,  May 2016 VL 106675 IU/mL .L31M in NS5A.Y93H not pres. No NS3 D168/A/F/H/N/Y

    in reply to: Genotype 1b relapsed after Viekira+Exviera #23128
    mcmak
    • Topics: 1
    • Replies: 3
    • Total: 4
    • Novice
    @mcmak

    Thank you for you knowledge. Yes, my mistake – I am waiting for ABT 493/530 with Sofo and Riba in trials.

    Do you think it is a good idea? And probably to not risk adding Riba which I am really afraid of is necessary?

    ad 2. Dasabuvir weak inhibitor – I have NS5A resistant variants probably not not NS3 variants. I was taking VPack+Exviera in trials phase 3, standard approved doses. I was asking for Ombitasvir. May it all mean that if I took Harvoni at that time I would also relapse?

    Why do people add Sofosbuvir to ABT493/530?

    in reply to: Genotype 1b relapsed after Viekira+Exviera #23114
    mcmak
    • Topics: 1
    • Replies: 3
    • Total: 4
    • Novice
    @mcmak

    1. Thank you – is it possible you give me a source that ledipasvir does not work for L31M please?

    2. I am wondering why ombitasvir in Viekira+Esviera did not work for L31M?

    3. You probably meant ABT450 not ABT-493?

Viewing 3 posts - 1 through 3 (of 3 total)