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I have relapsed after Viekira and Exviera in November 2015, genotype 1b. Now I am waiting for Vosevi which I hope to get in October. I am still thinking if I should not take Ribavirin additionally. I do not want to take it. 1. How many people from the forum where taking Vosevi for genotype 1b? Do you know anyone, any real-time data? If you know anyone on the forum please let me know. 
 
 2. I am trying to explain WHY Viekira+Exviera did not work for the L31M. Is it supposed not to work for this well?3. There is a table down in my letter from my blood tests after treatment- what does it mean 
 Ombitasvir |substitution on scored position | 31M
 Does it mean that Ombitasvir that I was taking did not work for this?From my findings: 
 NS-3 condones covered 1-181
 NS3 region (w.r.t M58335) – S7A, V48I, A66G, P86Q, K87A, P89S, F147L, V170l
 Ns3 region (w.r.t H77) – I35V, T42S,T61S, R62K, I64L, S66G, V71I,I72T, P86Q, Q89S, , S91A, I132V, A147L, L153I, N174S, L175M
 Resistance Analysis 
 Drug | Predicition | Scored mutations
 Asunaprevir | suspecitble | none
 Boceprevir | susbstituion on second position. | 170I
 Grazoprevir | suspectible | none
 Paritaprevir| suspectible |none
 Simeprevir| substitution on scored position | 170l
 Telaprevir |substitution on scored position | 170I
 
 NS5A condons covered. 1-104 
 NS5A Region (w.r.t. D9020 . – K6R, S17A, L31M, L34V, L37F,  G49A, Q54H, K68R, S101A . – K6R, S17A, L31M, L34V, L37F,  G49A, Q54H, K68R, S101A
 NS5A region (w.r.t. H77) I8V, E14T, S17A, K24Q, A25S, M28L, Q30R, L31M, I34V, V37F, R44K, G49A, R56T, H58P, E62Q, K68R, T71S, R78K, R81S, M83T, S85H, L101A
 
 Resistance Analysis
 Drug | Prediction | Scored mutations
 Daclatasvir | reduced suspectibility | 31M
 Elbasvir | resistant | 31M
 Ledipasvir | suspectible | 31M
 Ombitasvir |substitution on scored position | 31M
 
 Velpatasvir supsectible noneAND MY HISTORY: 
 Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U start of treatm. After 2 weeks 120U. After a month below possib of detect. After 3 months UND.3EOT UND. 4wEOT RELAPSED,14Dec2016 VL 27000 IU.mL,Feb 2016 VL 24296 IU/mL, May 2016 VL 106675 IU/mL .L31M in NS5A.Y93H not pres. No NS3 D168/A/F/H/N/YThank you for you knowledge. Yes, my mistake – I am waiting for ABT 493/530 with Sofo and Riba in trials. Do you think it is a good idea? And probably to not risk adding Riba which I am really afraid of is necessary? ad 2. Dasabuvir weak inhibitor – I have NS5A resistant variants probably not not NS3 variants. I was taking VPack+Exviera in trials phase 3, standard approved doses. I was asking for Ombitasvir. May it all mean that if I took Harvoni at that time I would also relapse? Why do people add Sofosbuvir to ABT493/530? 
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