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I have relapsed after Viekira and Exviera in November 2015, genotype 1b.
Now I am waiting for Vosevi which I hope to get in October. I am still thinking if I should not take Ribavirin additionally. I do not want to take it.
1. How many people from the forum where taking Vosevi for genotype 1b? Do you know anyone, any real-time data? If you know anyone on the forum please let me know.
2. I am trying to explain WHY Viekira+Exviera did not work for the L31M. Is it supposed not to work for this well?3. There is a table down in my letter from my blood tests after treatment- what does it mean
Ombitasvir |substitution on scored position | 31M
Does it mean that Ombitasvir that I was taking did not work for this?From my findings:
NS-3 condones covered 1-181
NS3 region (w.r.t M58335) – S7A, V48I, A66G, P86Q, K87A, P89S, F147L, V170l
Ns3 region (w.r.t H77) – I35V, T42S,T61S, R62K, I64L, S66G, V71I,I72T, P86Q, Q89S, , S91A, I132V, A147L, L153I, N174S, L175M
Resistance Analysis
Drug | Predicition | Scored mutations
Asunaprevir | suspecitble | none
Boceprevir | susbstituion on second position. | 170I
Grazoprevir | suspectible | none
Paritaprevir| suspectible |none
Simeprevir| substitution on scored position | 170l
Telaprevir |substitution on scored position | 170I
NS5A condons covered. 1-104
NS5A Region (w.r.t. D9020. – K6R, S17A, L31M, L34V, L37F, G49A, Q54H, K68R, S101A
NS5A region (w.r.t. H77) I8V, E14T, S17A, K24Q, A25S, M28L, Q30R, L31M, I34V, V37F, R44K, G49A, R56T, H58P, E62Q, K68R, T71S, R78K, R81S, M83T, S85H, L101A
Resistance Analysis
Drug | Prediction | Scored mutations
Daclatasvir | reduced suspectibility | 31M
Elbasvir | resistant | 31M
Ledipasvir | suspectible | 31M
Ombitasvir |substitution on scored position | 31M
Velpatasvir supsectible noneAND MY HISTORY:
Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U start of treatm. After 2 weeks 120U. After a month below possib of detect. After 3 months UND.3EOT UND. 4wEOT RELAPSED,14Dec2016 VL 27000 IU.mL,Feb 2016 VL 24296 IU/mL, May 2016 VL 106675 IU/mL .L31M in NS5A.Y93H not pres. No NS3 D168/A/F/H/N/YThank you for you knowledge. Yes, my mistake – I am waiting for ABT 493/530 with Sofo and Riba in trials.
Do you think it is a good idea? And probably to not risk adding Riba which I am really afraid of is necessary?
ad 2. Dasabuvir weak inhibitor – I have NS5A resistant variants probably not not NS3 variants. I was taking VPack+Exviera in trials phase 3, standard approved doses. I was asking for Ombitasvir. May it all mean that if I took Harvoni at that time I would also relapse?
Why do people add Sofosbuvir to ABT493/530?
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