I so hate this virus.

P

Dr F was thinking about using it so I asked Dr Dieterich if perhaps adding chlorcyclizine to DAAs could maybe increase success rate and would a dose of 75 mg at bedtime be enough in his opinion and he said….

“While there is good invitro data there does not yet seem to be any human data for this so there is no dosage information or drug interaction data. So an abundance of caution would lead me to not recommend it yet. Good luck with it!”

So I asked him if he thought a dose of 75mg would be enough and he said yes and to let him know how it went.

P.

I see it a different way Beaches.
As Dr Ponzetto said sof IS a 5fluoro uracil-

“Sofosbuvir is a phosphoramidate prodrug that is metabolized in the liver to β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine-5′-monophosphate.”

https://www.dovepress.com/changing-the-face-of-hepatitis-c-management-ndash-the-design-and-devel-peer-reviewed-article-DDDT

Knowing exactly what you’re taking can help prevent, identify and treat side effects. For example, the literature says that skin redness can be helped by Pyridoxine (Vitamin B6). Obviously, everything should be checked with your doctor.

https://books.google.com/books?id=CDADMzS0TKUC&pg=PA161&lpg=PA161&dq=5FU+and++cutaneousYHXuc2V0&hl=en&sa=X&ved=0ahUKEwi5qqnnhJLOAhUUT2MKHc4fArwQ6AEISTAG#v=onepage&q=5FU%20and%20%20cutaneous%20toxicity&f=false +toxicity&source=bl&ots=dNje7r1NGT&sig=RhgFPgLWtnXjAHO_po-

Gaj,
“For people with genotype 3 though, the link between steatosis and the virus has now been definitively established. Up to 80% of people with genotype 3 have moderate to severe steatosis. It seems that that there is a complex interaction between the core protein of the genotype 3 strand of the virus and liver cells that leads to steatosis. This interaction is not seen in other genotypes. It also seems that the severity of steatosis in these patients is directly related to their viral load. The higher the viral load the greater the amount of steatosis.”

Plus, the steatosis is around the portal areas, rather than in the middle of the lobules of the liver like the usual steatosis.

http://hepatitiscnewdrugresearch.com/fatty-liver-and-hcv.html

Reducing dietary saturated fat is associated with an increase in LDL-receptor abundance (which helps the virus multiply) of magnitude similar to the decrease in serum LDL-cholesterol (which is what happens with geno 3).

So it looks like your new diet will have to include restriction of PUFAs in favor of big fat steaks, and eggs and bacon for breakfast instead of cereal, butter, coconut oil ick:' /> ….and treat during winter when chol is higher (because of seasonal variations in bile acids).

P

Split dog, if you have genotype 1 which is associated with having insulin resistance and you’re overweight, then lowering your weight BEFORE you start treatment should help.

Londongirl, thin people can also be insulin resistant and steatosis but obviously if you’re underweight then loosing weight would not be recommended. But diet can always be improved. I would concentrate on having less carbs and more protein if ok with your doc (since he’s the one familiar with your case).

Most of the patients weren’t able to finish treatment. Plus, they all used Ribavirin and people waiting for transplant are usually anemic so the Riba dose is usually lower. So this study taught us that suboptimal dosing and unfinished treatment in immunocompromised patients leads to small amounts of virus being left over.
P.

Serg, I also think that you need to take into consideration whether you treated and failed treatment previously because studies have shown that may impact their health in the future.

P.