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I can’t sign. US is not on the list.
Passing it to Brazil
20 June 2016 at 12:58 am in reply to: Is there any evidence of DAAs impacting kidney function? #19510Because the calculation works best for estimating reduced kidney function, the National Kidney Foundation suggests only reporting actual results once values are < 60 mL/min (they state normal values as 90-120 mL/min). An eGFR below 60 mL/min suggests that some kidney damage has occurred. So 60 is the number to watch for. We had someone in our group end up on dialysis after Harvoni BUT he started with a GFR below 60. He probably would have ended on dialysis anyway. P
One study says yes….
“Unexpected early tumor recurrence in patients with hepatitis C virus -related hepatocellular carcinoma undergoing interferon-free therapy: a note of caution.”
http://www.ncbi.nlm.nih.gov/pubmed/27084592
Another study says no…..
Lack of evidence of an effect of Direct Acting Antivirals on the recurrence of hepatocellular carcinoma: The ANRS collaborative study group on hepatocellular carcinoma (ANRS CO22 HEPATHER, CO12 CIRVIR and CO23 CUPILT cohorts).
http://www.ncbi.nlm.nih.gov/pubmed/27288051
P.
18 June 2016 at 11:46 am in reply to: Such is the situation of Hep C sufferers in Brazil right now #19438That’s 45,000 12 week treatments, but many of their patients need 24 weeks of treatment.
P.
Having untreated infections during interferon treatment made it more difficult to clear HCV. So maybe having two infections raises the viral load.
Both acute and chronic ethanol exposure can modify immune responses to bacterial and viral pathogens.
You need to do it fasting because it can also tell you if you’re insulin resistant.
P.
The product monograph for Sovaldi (page 12) lists 6% blood sugar >250 (13.9). That’s diabetes but they don’t list diabetes. It also lists fungal infections (page 10). There are actually quite a few side effects that are not listed on the medication insert.
http://www.gilead.ca/pdf/ca/sovaldi_pm_english.pdf
Things like palpitations, chest pain, visual impairment, basal cell carcinoma and amaurosis fugax (a transient monocular or binocular vision loss that appears as a “curtain coming down vertically into the field of vision in one eye;”
That sounds just like a detached retina. One of our Vets had a detached retina while on Harvoni.
The Harvoni monograph lists blood sugar >160 (8.9) in 9% for the 8 week group, 10% for the 12 week group and 12% for the 24 week group.
Again, a fasting blood sugar of 160 is diabetes but they don’t list diabetes or say whether it resolved.P
I really don’t see what the problem is. They’re advertising generics and so are you. So if they can do it why can’t you?
P.
beaches,
You can’t judge blood sugar based on how thirsty you are. Your body can become used to having high blood sugar and the symptoms may decrease.Some doctors think that the hypoglycemic of today is the diabetic of tomorrow. Because when your blood sugar starts going up, the pancreas works faster to make enough insulin to keep your blood sugar within the normal limit but sometimes it produces too much insulin, which can cause hypoglycemia (like your 4). Eventually, the pancreas might not be able to keep up the fast pace and the blood sugar starts going up and the person becomes a diabetic.
So it’s best to get your blood sugar checked.
P.
GT2…..
If you have a fasting blood sugar of 11.6 then you’re, at least, insulin resistant, which causes leaky gut. GI problems, like reflux, can also cause leaky gut.P.
The two sllides on the links I posted come from some “expert” presentation, I forget which.
P.
GT2…
Sometimes I have these brilliant ideas that turn out not to be so brilliant after all. So this one time I decided to help somebody put a prebiotic on the market to help people with hep c. So I talked my research partner into joining me and spent a couple off years researching pro/prebiotics. So if you don’t mind, I’d like to share some of what I learned.PRObiotics, as you said are live beneficial bacteria. PREbiotics are cell wall fragments from dead bacteria (that’s why they don’t have to be refrigerated). Prebiotics are not food for probiotics. They don’t feed microbiota. They stimulate the intestinal goblet cells to increase and to produce more mucus. Microbiota, specifically Akkermansia Muciniphila (the dominant bacteria in humans), then harvest sugars from the mucus and use them as food source.
A decrease in the abundance of Akkermansia muciniphila in gut microbiota causes reduced production and layer thickness of mucus and reduces gut permeability. In other words, it causes LEAKY GUT. Leaky gut can be caused by antibiotics disrupting normal intestinal flora, obesity, Cirrhosis, high cholesterol, Insulin resistance/Diabetes, fatty liver, alcohol use, GI problems (like stomach ulcers, diarrhea, Barrett’s esophagus, H,Pylori infection, colitis, etc).
Why is having leaky gut a problem?
The liver is the first organ that encounters venous blood from the small and large intestines via the portal vein. So that makes the liver vulnerable to exposure of bacterial products coming from the intestines. Translocation of large amounts of gut-derived products is usually prevented by an intact barrier system. So in a healthy organism only minor quantities of bacterial products reach the liver. In general, the liver tolerates small amounts of bacterial products in order to avoid harmful responses, but damage of the intestinal epithelial barrier results in a leaky gut that lets large amounts of bacterial products reach the liver.
Bacterial products, otherwise called Lipopolysaccharide are large molecules consisting of a lipid and a polysaccharide found on the outer membrane of gram negative bacteria. When they reach the liver, they act as ENDOTOXIN and elicit a strong reaction from your immune system which can cause inflammation and contribute to the initiation and progression of liver disease.
So as you can see, pro/prebiotics are much more than food.
http://dmg98m9mr6pi1.cloudfront.net/user_photos/518556?1420633029
http://dmg98m9mr6pi1.cloudfront.net/user_photos/518557?1420656332P.
GT2…
All the yogurt in the world won’t get rid of yeast if your fasting blood sugar is 11.6. High blood sugar causes yeast infections.You should look into the high sugar. 11.6 is diabetes.
P.
6 June 2016 at 1:09 am in reply to: Will France be able to push Gilead to lower the HCV drugs price? #18473 -
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