Forum Replies Created

Viewing 15 posts - 181 through 195 (of 307 total)
1 2 3 … 12 13 14 … 19 20 21
  • Author
    Posts
  • 2 February 2016 at 3:36 pm in reply to: Prof Ed Gane’s remarks: implications for Twinvir #11002
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Hi Chapel,

    I don’t remember what prof Gane said about Sofosbuvir alone and rebound after SVR. I don’t have time to listen again to the broadcast. But here is an earlier post from Dr James on log kill and treatment failure mechanisms:

    https://fixhepc.com/forum/resistance/164-resistance-and-treatment-failure-mechanisms.html

    The key is to zap the virus as quickly as possible with a high log kill in the first weeks. Then even if “UND” might mean a few undetectable stragglers remain, a few more weeks of treatment would guarantee that they also eventually get whacked. I imagine that if someone gets UND on Sof alone, then there would only be a risk of rebound if the UND appeared right at the end of the treatment. So this is why a dual DAA combo is always recommended, and why triple or even quad-combos (3-week treatment) is the way of the future:

    https://fixhepc.com/forum/media-news/512-raymond-schinazi-rational-pricing-generics.html#6378

    If 3-weeks of quad-DAA really is enough, it seems to me that this must mean reaching UND in just a few days!

    So if you or Lynn are at UND after 4 weeks on dual-DAAs, it seems a pretty safe bet that you can now relax and enjoy the show…

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    2 February 2016 at 1:33 pm in reply to: Prof Ed Gane’s remarks: implications for Twinvir #10991
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    To have someone like Prof Gane speaking publicly about sourcing and using generics is an extremely strong endorsement of what Dr James is doing. Yes, there is the usual institutional caution – don’t forget he is speaking as both individual specialist, but also as a representative of the NZ health service. So it is quite correct that he should voice some reservations about the authenticity of medications that have not been approved by MedSafe.

    The only remark that I found difficult to accept was the notion that someone *might* achieve a SVR under generic versions of Sofosbuvir plus Ledipasvir but then in some way be more likely to rebound if they had taken a sub-standard version of Ledipasvir.

    This seems to suggest that one can have UND (meaning undetectable because there absolutely no virus to detect), and UND meaning still some virus remaining (but an undetectable amount) which also has some “memory” that the Led taken was sub-standard. This seems to me to be arguing about what might happen with some tiny handful of hypothetically-still-existing virus particles which somehow might “know” what they are allowed to do next…

    Last virus particle #1: Shoot, where has everyone gone?

    Last virus particle #2: They just got zapped by a sub-standard version of of Ledipasvir. We’re the only two left.

    Last virus particle #1: It was sub-standard? Ok, let’s start replicating again then.

    Last virus particle #2. Urghhh.

    Last virus particle #1. What was that?

    Last virus particle #2. An antibody just ripped my head off. So long…

    Last virus particle #1. Oh no, another antibody… Self-destruct in T-5 seconds…

    If one gets down to UND during treatment, then surely the Sof+Led combo has done the job regardless of their crystal forms, and the usual SVR projections with the usual margins of error should apply?

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    2 February 2016 at 1:19 am in reply to: FixHepC – Party Playlist #10943
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Don’t know exactly why, but there is something about hepatitis C that makes me think of vampires… :evil: But who cares, vampires don’t exist and Hep-C might soon be dead? B)

    The original movie with Bela Lugosi:

    The original song by Bauhaus:

    https://www.youtube.com/watch?v=OKRJfIPiJGY

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    2 February 2016 at 12:58 am in reply to: From Lucinda Porter #10939
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Hi Tommy,

    Here is a PDF of the full article by Lucinda Porter that I think you are referring to…

    (when writing a post there is a button below the text box that says “Add File”. You can use that to attach a PDF after you have saved it on your hard drive; you can also just paste the link from your brower directly into the text box like this

    http://fixhepc.com/media/kunena/attachments/623/advocate0216.pdf

    )

    Attachments:

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    30 January 2016 at 4:18 am in reply to: FixHepC – Party Playlist #10772
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Joe Cocker…

    https://www.youtube.com/watch?v=eSxXHoFYhKU

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    30 January 2016 at 3:55 am in reply to: More nausea-inducing news about Gilead’s strategy #10770
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Thanks, LG. Very interesting!

    Does this mean that Gilead executives are starting to feel the heat?

    Or maybe quit while they’re ahead??

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    30 January 2016 at 3:03 am in reply to: Any Post-Treatment Reflections? #10764
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    I can completely agree with Mike’s comments, although my starting point was much less severe than his. Knowing there is a treatment available, but that the cost to national health services makes it still out of reach was an incredible source of anger and frustration to me. Even though I knew I was not a severe case as far as fibrosis tests are concerned, I also knew that the virus was having a serious effect on my health in lots of small ways. Before treatment, it seemed like I had been driving around in 2nd gear for years. And I kind of got used to it. I didn’t know any more what it was like to be normal and healthy. A few weeks ago, I posted some improvements that I noticed after just 4 weeks of treatment.

    http://fixhepc.com/forum/questions-and-answers/527-improvements-during-and-after-hcv-treatment.html?start=6#6824

    Lots of little things just got better. After just 4 weeks, it was like my body had suddenly re-discovered 3rd gear, and I could drive all day on that. It was also like I could give an explanation to the fatigue, the skin problems, the nose-bleeds, the bruises, because all that has now long gone.

    Today, I am 3 days away from the end of 84 days of Sof+Dac. About 10 days ago, it seemed like I changed gear again. and I can now speed along in 4th gear all day. I can now work a 12-hour day, and still have energy and still be in a good mood in the evening…

    Probably there is a psychological aspect to some of that. Some people might even try to put the previous fatigue and skin problems down to psychology. But I had those problems before I knew I had Hep-C! And the rest? I don’t think so! On the other hand, there is a lot of positive psychology going on through just feeling better. For example, it also seems like everyone at work looks at me differently because I feel better and I look better.

    Am I “officially cured”? I don’t know yet. Still awaiting the famous Week-12 blood tests. Still looking forward to the “SVR24” test. But I certainly feel like I am cured. And even if I am not, I now know what it feels like at my age to live at least for a few weeks without that bastard virus.

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    30 January 2016 at 2:08 am in reply to: Cheating Fibroscan #10759
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Well, if the rules are arbitrary and unfair, and basically designed to exclude people from treatment in the first place, to quote John Lyle:

    “All’s fair in love and war” …

    And as far as Gilead are concerned, we’re not talking about love!

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    25 January 2016 at 12:10 am in reply to: VA in USA urged to invoke emergency powers #10323
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Here is an interesting article from Chatham House (a UK-based “think-tank”;) on pricing medicines:

    https://www.chathamhouse.org/expert/comment/medicines-pricing-there-better-way

    It starts with Hepatitis C, but then goes on to talk about antibiotics (there is a global health crisis waiting to explode here as well). For antibiotics (but maybe not only antibiotics), there is an emerging idea that governments should force Big Pharma to “de-link” revenues from sales.

    You can follow the links for yourselves, but there is a very nice proposition from economist Andrew Sachs that seems brilliantly simple and fair:

    http://www.huffingtonpost.com/jeffrey-sachs/rational-drug-pricing_b_8188790.html

    Here is my own (super-simple) understanding how it should be:

    World governments: Hey, there is a major health problem that we want to treat. We will to pay Big Pharma to find a solution. We will then let Big Pharma make 10x profit (say) on their investment. But Big Pharma must then make the treatment available to everyone at the same price. And because we (the government) funded the research, we (the government) want a share of the intellectual property (patents).

    Big Pharma: Great! We are guaranteed a 10x profit on our R&D costs. We will go ahead and try to make the really innovative products you want. Who cares about sales & marketing! We will hand all that stuff over to other countries where everyone knows they can do that cheaper than us anyway.

    World governments: OK, Great! Let’s do it! This way, we can treat everyone at a reasonable cost,. But you still have to pay all your taxes here, and not in Ireland.

    Big Pharma: Ah, well, you see it’s not as simple as that… (joke).

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    23 January 2016 at 4:51 pm in reply to: We Need an App!! #10205
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Hi,

    A GP2U app for android and apple is available here:

    https://play.google.com/store/apps/developer?id=GP2U%20Telehealth&hl=en (android)
    https://itunes.apple.com/us/app/gp2u-telehealth-online-doctors/id625961235?mt=8 (apple)

    The FixHepC web site works well on my android phone, and I noticed just today that someone has removed the public chat pop-up, which could not be minimised after it was opened (quite annoying). So I would say that FixHepC now works pretty well on mobile devices.

    [Hmm, seems like the public chat is now gone from the desktop version as well. Is this a new bug or a new feature?]

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    22 January 2016 at 4:11 am in reply to: US Moderator announces our drugs are ILLEGAL #10054
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Here’s a screenshot attached, just for the record. I don’t know how to paste an image directly. Maybe someone can explain how to?

    Attachments:
    • delphi-21-jan-2016.png

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    22 January 2016 at 3:38 am in reply to: any one else have a co-infection with HVB? #10048
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Hello Suzy,

    You are in France? You are looking at the map of “Geographical Eligibility for REDEMPTION?” For many countries, the red dot does not necessarily mean it is “forbidden”. It just means that mailing to that country has not been proved to work (if I understand correctly).

    However, in France, it is unfortunately against the law to buy medicines on-line or to import them unless you bring them with you personally as a traveller (this seems to be the rule in many european countries). This means that in France, there is a risk that if you try to import medications directly in the mail, they could be confiscated by French Customs.

    Here are some links: http://fixhepc.com/forum/questions-and-answers/322-france-medication-import-regulations.html

    So the best option for you if you want to follow the law strictly would be to have your medication delivered to your address in London (of course, you have an address there if you have friend there!), and then take a quick visit there on the Eurostar to collect it.

    Bringing your medication into France as a personal traveller would then be a perfectly legal thing for you to do…

    In the completely hypothetical situation that you cannot travel to London and your friend might post something to you from London to France, some people might say that it is less likely (but not impossible) that French customs would look at a parcel coming from inside the EU than a parcel coming from outside the EU. This is just a hypothetical possibility and I would never advise anyone to take such a risk with their life-saving medication. So because this in a public form, and because we must not encourage anyone to break any laws anywhere, I would like to advise you again to never even think about the possibility of posting medication from the UK to France.

    [The fact that it is against the law in France to import one’s own life-saving medication is of course a crazy situation. But do not fear. Gilead have no power to change French law. And importing one’s own personal medication as a traveller is perfectly legal almost everywhere in the world, including France.]

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    22 January 2016 at 1:05 am in reply to: REDEMPTION is “Official” in the U.S.! #10025
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Dr James does it again!

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    22 January 2016 at 12:01 am in reply to: Once upon a time… #10020
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Good point re-roll.

    There is now a heck of a lot of good advice hidden here that many new people miss. In my spare time, I am collecting up some posts that could go into a new FAQ.

    But there are now over 8500 posts here (and over 400 from Dr James), so I am trying to figure out how to do it automatically…

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    21 January 2016 at 3:38 am in reply to: VA in USA urged to invoke emergency powers #9943
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    This is maybe going off-topic, but since there are at least two people on this thread who might be interested/capable:

    Would it be technically possible to have a little button next to each post that says something like “Hide/Unhide” or “Shrink/Enlarge”? This would then minimise the message to show only the first line or two, for example?

    I ask only because there are more and more one-liners on the forum like “Great news!”, “Glad you are doing so well!”, etc, which are great to see for the first time (especially for the intended recipient) but which become a bit heavy to scroll through when trying to follow the original topic of the thread on a slow connection.

    [Mods: please feel free to move this to the technical section if you see fit]

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

  • Author
    Posts
Viewing 15 posts - 181 through 195 (of 307 total)
1 2 3 … 12 13 14 … 19 20 21