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  • 8 January 2016 at 5:35 am in reply to: Delivery #8334
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Sorry I’m late to congratulate you guys – woohoo! great stuff LG and Debs :)

    Very happy for you both – finally! :cheer:

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    8 January 2016 at 5:19 am in reply to: The Ducks (Smileys) Are Lined Up #8333
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    #woohoo!

    :lol: :lol: :lol:

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    8 January 2016 at 5:17 am in reply to: Shaving Blades , Toothbrushes, Nail clippers etc ? #8332
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Ha, a little maybe yes Tina!

    (though I cannot compare to the mighty Georgi lol)

    One week down today, and I’m sure as hell keeping my fingers crossed for that 4 wk VL marker – anything under 200,000 is gonna be going in the right direction :P

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    8 January 2016 at 5:02 am in reply to: Dan’s Twinvir story #8331
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk
    splitdog wrote:

    The way I understand it, ‘Quantitative’ testing determines the actual number per ml of bloodborne virus. However, it is only accurate between 12 and 10,000,000. The ‘Qualitative’ testing is far more accurate, but can only determine present/not present. So you use quantitative to see how you’re doing until <12, then do qualitative to see if it goes all the way down to undetected. (zero). Dr. Freeman?

    Hey splitdog, pretty much. Check out the Doctor's cheat sheet link for a summation

    Monitoring

    Now the patient has access to the medications here is what monitoring on treatment looks like:

    Baseline FBC, Cr&E, LFTs, Hep C Viral Load with reasonable currency + AFP and liver ultrasound for those with cirrhosis (looking for HCC)
    4/52 into treatment FBC, Cr&E, LFTs, Hep C Viral Load
    Repeat Viral Load at 4/52 intervals if not zero at 4/52
    EOT (End Of Treatment) exit bloods

    Hep C Viral Load can be quantitative (undetectable, <15, or 15-100,000,000) or qualitative (undetected/detected).

    http://fixhepc.com/getting-treated/how-to-do-it/doctors.html

    Thanks too for the great exposition Vovoro, very well explained :+1:

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    8 January 2016 at 4:48 am in reply to: Shaving Blades , Toothbrushes, Nail clippers etc ? #8329
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    I’ve grabbed cheap no names in bulk packs, new razor every use where there’s more of a chance of drawing a bit of blood, new toothbrush every week or two (or that’s the plan).

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    7 January 2016 at 4:32 pm in reply to: Soy an inducer of CYP3A4 ? #8272
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Cheers GAJ :)

    Well I habitually take 3000 mg/day, usually a couple of hours after the dac…but not from tomorrow lol

    Hopefully it hasn’t done too much harm, as its only been one week. Fingers crossed

    And I am a semi ‘recovering vegetarian’ lol so salmon could well be on the cards :P

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    7 January 2016 at 2:41 pm in reply to: Dan’s Twinvir story #8257
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    With only 4 weeks down, you’re on the verge of undetected Dan…you will be fine :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    7 January 2016 at 2:38 pm in reply to: So, the battle is joined! #8256
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Cheers Debs!

    And I hope the same for you, when the time comes for you to get started :)

    Most of the time you can forget that you’re even on treatment – and if that isn’t a ringing endorsement, I don’t know what is Lol

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    7 January 2016 at 2:22 pm in reply to: Soy an inducer of CYP3A4 ? #8252
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    With you on that Pheonix, something definitive…but ditching it just in case seemed the wisest move.

    What about omega? I hadn’t read anything that would contraindicate fish oil, for example (have been taking it daily as I usually do)

    Apologies for my late showing here guys , dodgy net connection was playing up with the recent rain/monsoon lol :pinch:

    Edit: Right, now I’m confused…two contradictory links for omega-3

    (Although possibly the webmd link is concermed with all those substances taken together, I’m not sure)

    http://www.drugs.com/drug-interactions/daclatasvir-with-fish-oil-ultra-3644-0-1749-14959.html

    http://www.webmd.com/drugs/2/drug-152082/folic-acid-omega-3-dha-epa-st–john’s-wort-oral/details/list-interaction-details/dmid-2499/dmtitle-potent-cyp

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    7 January 2016 at 1:11 pm in reply to: So, the battle is joined! #8245
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Hey everyone, been off here for a couple of days and tomorrow rolls around to a week on treatment – one down 11 to go!

    Gotta say its been, well as uneventful as expected. Few sides apart from occasional liver twinges, a few headaches and a hint of nausea that never came to anything much. Monday was probably my best day so far, couple of times I actually had a hint of something which might be “a free-floating sense of wellbeing”, something so foreign to me usually that it made me stop and notice it lol

    The speedy feeling you mentioned Paul – it turned up along with insomnia for a couple of night and one where I had restless legs the whole night (something I used to get many years ago, but remember it al too vividly lol) Not sure if its tx-related though, and my legs do have that slight ‘buzzing’ sometimes. The feeling of mental “clarity’ disappears sometimes (particularly with a headache) but its never disappeard :)

    But all good – overall really not much to speak of. I’m sure that if the sides increase a bit it will be a dosage-related event, as the level builds up in my blood…still early days :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 11:39 am in reply to: 2B HERE #8023
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Fantastic news, Joan! Great to hear, congratulations :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 11:31 am in reply to: Soy an inducer of CYP3A4 ? #8022
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Seems not, fox (speaking tentatively)

    Both sofosbuvir and ledipasvir are not metabolized by the cytochrome P450 system of enzymes but rather are substrates for p-glycoprotein.

    https://www.ncbi.nlm.nih.gov/pubmed/25553890

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 10:23 am in reply to: Two weeks Twinvir Undetected #8018
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Awesome news, Enkel! – congrats :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 10:18 am in reply to: Soy an inducer of CYP3A4 ? #8016
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Hear you on that, Pheonix. And I just found out the supposedly 100% whey protein I’ve been taking, wasn’t :pinch: (soy lecithin, in very small type lol) Only found one brand today which promised NO soy, well fingers crossed.

    Few other herbal/supplements too

    http://fixhepc.com/forum/drug-interactions/329-herbs-and-liver-safety.html#3028

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    4 January 2016 at 4:35 pm in reply to: Dan’s Twinvir story #7949
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Good figures there Dan! sorry you’re having complications due to your ezcema. Hope the AB’s sort it out.

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

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Viewing 15 posts - 121 through 135 (of 543 total)
1 2 3 … 8 9 10 … 35 36 37